公开(公告)号：US20080319018A1

公开(公告)日：2008-12-25

申请号：US12146073

申请日：2008-06-25

申请人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuku Hitomi ,  Atsushi Toyao

发明人： Fumiaki Yokokawa ,  Takeru Ehara ,  Shimpei Kawakami ,  Osamu Irie ,  Masaki Suzuki ,  Yuku Hitomi ,  Atsushi Toyao

IPC分类号： A61K31/4545 ,  C07D401/12 ,  A61P43/00

CPC分类号： C07D401/12

摘要： The present invention relates to a compound of the formula I wherein R1, R2, R3, R4 and R5 are as defined in the specification, for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations a compound of that class; a method of treatment comprising administering a compound of that class and a method for its manufacture.

摘要翻译： 本发明涉及式I化合物，其中R1，R2，R3，R4和R5如说明书中所定义，用于诊断和治疗温血动物，特别是用于治疗疾病 （=无效），依赖于肾素的活性; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 药物制剂是该类化合物; 一种治疗方法，包括施用该类化合物及其制备方法。