Method for synthesizing chiral bicyclic thiazolidine hydantoin
    1.
    发明申请
    Method for synthesizing chiral bicyclic thiazolidine hydantoin 审中-公开
    手性双环噻唑烷乙内酰脲合成方法

    公开(公告)号:US20050159602A1

    公开(公告)日:2005-07-21

    申请号:US10758223

    申请日:2004-01-16

    CPC classification number: C07D513/04

    Abstract: A method for synthesizing chiral bicyclic thiazolidine hydantoin that uses L-(+)-Cysteine, an aldehyde, and a preferred benzylisocyanate as reactants with additive solid molecular sieves to efficiently synthesize chiral bicyclic thiazolidine hydantoin crystallization having high purity. This method can be operated within only a singular reacting chamber without isolating intermediates in this method. Thereby, operational procedures of the present invention are simplified to make the method economic.

    Abstract translation: 合成手性双环噻唑烷乙内酰脲的方法,其使用L - (+) - 半胱氨酸,醛和优选的苄基异氰酸酯作为具有添加剂固体分子筛的反应物,以有效合成具有高纯度的手性双环噻唑烷乙内酰脲结晶。 该方法只能在单一反应室内操作,而无需在该方法中分离中间体。 因此,本发明的操作程序被简化以使该方法具有经济性。

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