公开(公告)号：US5124331A

公开(公告)日：1992-06-23

申请号：US439044

申请日：1989-11-02

申请人： Masafumi Arita ,  Yoshitaka Fukumasu ,  Mitsuharu Sano ,  Yukio Hoshino ,  Hirotsugu Komatsu

发明人： Masafumi Arita ,  Yoshitaka Fukumasu ,  Mitsuharu Sano ,  Yukio Hoshino ,  Hirotsugu Komatsu

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： 3,4-Dihydrothieno[2,3-d]pyrimidine compounds having immunoregulating and carcinostatic actions of the general formula ##STR1## wherein A represents a C.sub.1-4 alkylene; R.sup.1 represents hydrogen, an alkyl, an aryl which may be substituted or --N(R.sup.7)(R.sup.8); R.sup.2, R.sup.3 and R.sup.4 represent hydrogen, a halogen, hydroxy, an alkyl which may be substituted by a halogen, an alkoxy, nitro, cyano or --N(R.sup.9)(R.sup.10); R.sup.5 represents hydrogen, a halogen, nitro, amino, cyano, an alkyl or an alkoxycarbonyl; R.sup.6 represents hydrogen, a halogen, nitro, amino, cyano, an alkyl, an alkoxycarbonyl, a halogenosulfonyl or --SO.sub.2 N(R.sup.12)(R.sup.13); or R.sup.5 and R.sup.6 may, taken together, form a C.sub.3-6 alkylene chain, and their pharmaceutical use.