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1.发明授权Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein 失效制备用于其中的卡培他滨和β-异头物富含三烷基碳酸酯化合物的方法公开(公告)号：US08097706B2
公开(公告)日：2012-01-17
申请号：US12742367
申请日：2008-11-07
申请人： Jaeheon Lee , Gha-Seung Park , Weon Ki Yang , Jin Hee Kim , Cheol Hyun Park , Yong-Hoon An , Yoon Ju Lee , Young-Kil Chang , Gwan Sun Lee
发明人： Jaeheon Lee , Gha-Seung Park , Weon Ki Yang , Jin Hee Kim , Cheol Hyun Park , Yong-Hoon An , Yoon Ju Lee , Young-Kil Chang , Gwan Sun Lee
CPC分类号： C07D405/04 , C07H1/00 , C07H19/06 , Y02P20/55
摘要： The present invention relates to a method for preparing capecitabine and a method for preparing a β-anomer-rich trialkyl carbonate compound used therein, and a highly pure capecitabine can be efficiently prepared with a high yield by the method of the present invention using the β-anomer-rich trialkyl carbonate compound as an intermediate.
摘要翻译： 本发明涉及一种制备卡培他滨的方法和一种制备其中使用的富含甘油的三烷基碳酸酯化合物的方法，可以通过本发明的方法以高产率有效地制备高纯度的卡培他滨 富马酸三烷基碳酸酯化合物作为中间体。
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2.发明申请METHODS FOR PREPARING CAPECITABINE AND BETA-ANOMER-RICH TRIALKYL CARBONATE COMPOUND USED THEREIN 失效用于制备CAPECABABINE和用于其的BETA-异恶唑烷基碳酸酯化合物的方法公开(公告)号：US20100249395A1
公开(公告)日：2010-09-30
申请号：US12742367
申请日：2008-11-07
申请人： Jaeheon Lee , Gha-Seung Park , Weon Ki Yang , Jin Hee Kim , Cheol Hyun Park , Yong-Hoon An , Yoon Ju Lee , Young-Kil Chang , Gwan Sun Lee
发明人： Jaeheon Lee , Gha-Seung Park , Weon Ki Yang , Jin Hee Kim , Cheol Hyun Park , Yong-Hoon An , Yoon Ju Lee , Young-Kil Chang , Gwan Sun Lee
IPC分类号： C07H19/06 , C07D307/20
CPC分类号： C07D405/04 , C07H1/00 , C07H19/06 , Y02P20/55
摘要： The present invention relates to a method for preparing capecitabine and a method for preparing a β-anomer-rich trialkyl carbonate compound used therein, and a highly pure capecitabine can be efficiently prepared with a high yield by the method of the present invention using the β-anomer-rich trialkyl carbonate compound as an intermediate.
摘要翻译： 本发明涉及一种制备卡培他滨的方法和一种制备其中使用的富含甘油的三烷基碳酸酯化合物的方法，可以通过本发明的方法以高产率有效地制备高纯度的卡培他滨 富马酸三烷基碳酸酯化合物作为中间体。
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3.发明授权Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same 有权制备四唑甲磺酸盐的方法及其中使用的新化合物公开(公告)号：US08680277B2
公开(公告)日：2014-03-25
申请号：US13522272
申请日：2011-01-14
申请人： Keuk Chan Bang , Bum Woo Park , Jong Won Choi , Jae Chul Lee , Yong Hoon An , Young Gil Ahn , Maeng Sup Kim
发明人： Keuk Chan Bang , Bum Woo Park , Jong Won Choi , Jae Chul Lee , Yong Hoon An , Young Gil Ahn , Maeng Sup Kim
IPC分类号： C07D401/02
CPC分类号： C07D417/12 , C07D403/10 , C07D405/12 , C07D405/14
摘要： According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.
摘要翻译： 根据本发明，制备四唑甲磺酸盐的方法包括使用新的4-碘-4H-色烯-2-硫代硫酸S-苯并噻唑-2-基酯的酰化反应。 与常规方法相比，本发明的方法可以缩短反应时间并提高安全性，并且可以在不使用柱色谱法的情况下以高产率制备高纯度四唑甲磺酸盐。
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4.发明申请METHOD FOR PREPARING TETRAZOLE METHANESULFONIC ACID SALTS, AND NOVEL COMPOUND USED IN SAME 有权制备四唑甲磺酸钠盐的方法及其所用的新型化合物公开(公告)号：US20120330020A1
公开(公告)日：2012-12-27
申请号：US13522272
申请日：2011-01-14
申请人： Keuk Chan Bang , Bum Woo Park , Jong Won Choi , Jae Chul Lee , Yong Hoon An , Young Gil Ahn , Maeng Sup Kim
发明人： Keuk Chan Bang , Bum Woo Park , Jong Won Choi , Jae Chul Lee , Yong Hoon An , Young Gil Ahn , Maeng Sup Kim
IPC分类号： C07D405/14 , C07D417/12
CPC分类号： C07D417/12 , C07D403/10 , C07D405/12 , C07D405/14
摘要： According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.
摘要翻译： 根据本发明，制备四唑甲磺酸盐的方法包括使用新的4-碘-4H-色烯-2-硫代硫酸S-苯并噻唑-2-基酯的酰化反应。 与常规方法相比，本发明的方法可以缩短反应时间并提高安全性，并且可以在不使用柱色谱法的情况下以高产率制备高纯度四唑甲磺酸盐。
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