公开(公告)号：US20060287229A1

公开(公告)日：2006-12-21

申请号：US11172493

申请日：2005-06-30

Applicant: Dani Eshel ,  Galit Rotman ,  Kinneret Savitsky ,  Amir Toporik ,  Rami Khosravi ,  Aviva Chen ,  Yona Bismuth

Inventor： Dani Eshel ,  Galit Rotman ,  Kinneret Savitsky ,  Amir Toporik ,  Rami Khosravi ,  Aviva Chen ,  Yona Bismuth

IPC: A61K38/17

CPC classification number: A61K38/177

Abstract: The invention concerns CD40 skipping 5 nucleic acid sequences and amino acid sequences obtained by alternative splicing of CD40, pharmaceutical compositions comprising said sequences and methods for treatment of a disease, wherein a beneficial therapeutic effect is achieved by the up regulation of the CD40-R-CD40-L interaction. An antibody capable of selectively binding to the amino acid of CD40 skipping 5 and pharmaceutical composition comprising the above antibody and methods for detecting the presence of exon 5 skipping expression in a sample are also within the scope of the invention.

Abstract translation: 本发明涉及跳过5个核酸序列和通过CD40的选择性剪接获得的氨基酸序列，包含所述序列的药物组合物和治疗疾病的方法的CD40，其中有益的治疗效果通过上调CD40-R- CD40-L相互作用。 能够选择性地结合CD40跳跃5的氨基酸的抗体和包含上述抗体的药物组合物和用于检测样品中外显子5跳跃表达的存在的方法也在本发明的范围内。