公开(公告)号：US06476006B2

公开(公告)日：2002-11-05

申请号：US09770898

申请日：2001-01-26

申请人： Moshe Flashner-Barak ,  Vered Rosenberger ,  Mazal Dahan ,  Yitzhak Lerner

发明人： Moshe Flashner-Barak ,  Vered Rosenberger ,  Mazal Dahan ,  Yitzhak Lerner

IPC分类号： A01N5726

CPC分类号： A61K31/663 ,  A61K9/2027 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2866

摘要： The present invention provides compacted pharmaceutical composition for oral administration to a patient which expands upon contact with gastric fluid to retain a dosage form in the patient's stomach for an extended period of time, the formulation comprising a non-hydrated hydrogel, a superdisintegrant and tannic acid. The present invention further provides a pharmaceutical dosage form containing an active ingredient, and the compacted pharmaceutical composition. The invention further provides a dosage form suitable for delivering a therapeutic bis-phosphonate such as alendronate to the stomach of a patient over and extended period.

摘要翻译： 本发明提供了一种用于口服给予患者的压制药物组合物，所述药物组合物在与胃液接触时膨胀，以将剂型在患者的胃中长时间保持，该制剂包含非水合水凝胶，超级崩解剂和丹宁酸 。 本发明还提供含有活性成分和压实的药物组合物的药物剂型。 本发明进一步提供了适合于将治疗性双膦酸盐例如阿仑膦酸盐递送至患者胃部并持续延长的剂型。