公开(公告)号：US20090212225A1

公开(公告)日：2009-08-27

申请号：US12358750

申请日：2009-01-23

Applicant: Yiran Zheng ,  Barry W. Wessels

Inventor： Yiran Zheng ,  Barry W. Wessels

IPC: G01T1/166

CPC classification number: A61B6/037 ,  G06T7/11 ,  G06T7/136 ,  G06T7/62 ,  G06T2207/10104 ,  G06T2207/20008 ,  G06T2207/30096

Abstract: A method for positive emission tomography (PET) target image segmentation is provided. The method comprises capturing and digitizing image data of a selected target, determining an initial concentration ratio based on an initial source background ratio and an initial volume estimate of the selected target employing a concentration ratio table, determining a desired threshold from the initial concentration ratio and the initial volume estimate employing a threshold table, and determining a final volume estimate of the selected target based on the determined desired threshold.

Abstract translation: 提供了一种用于正发射断层摄影（PET）目标图像分割的方法。 该方法包括捕获和数字化所选择的目标的图像数据，基于初始源背景比和使用浓度比表选择的目标的初始体积估计来确定初始浓度比，从初始浓度比确定期望阈值，以及 使用阈值表的初始体积估计，以及基于所确定的期望阈值来确定所选择的目标的最终体积估计。

公开(公告)号：US20130267423A1

公开(公告)日：2013-10-10

申请号：US13819534

申请日：2011-08-29

Applicant: Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Yi Li Ang ,  Yiran Zheng ,  Sylvia Tan

Inventor： Su Seong Lee ,  Jaehong Lim ,  Junhoe Cha ,  Yi Li Ang ,  Yiran Zheng ,  Sylvia Tan

IPC: G01N33/68

CPC classification number: G01N33/6818 ,  C07K1/047 ,  C07K1/13 ,  C07K7/06 ,  C40B20/08 ,  C40B40/04 ,  C40B50/18 ,  C40B70/00

Abstract: The present invention generally relates to various peptides and particles, for example, for use in screening of particle- or bead-based peptide libraries. In one aspect, the present invention is generally directed to articles including peptides attached to one or more particles, which may have structures such as (particle)-M-Q-Zn-X-J, (particle)-M-Q-Zn—X1—X2—X3—X4—X5-J, (particle)-M-R—Zn—X1—X2—X3—X4—X5-J, (particle)-M-R—X1—X2—X3—X4—X5Zn-Q-J, (particle)-M-X1—X2—X—3X4—X5—Zn—R-J, etc., where M is a methionine residue, M1 is a cleavable linker residue, Q is a group able to enhance intensity and/or sensitivity of mass spectrometry, X comprises one or more amino acid residues, n is a positive integer, Z is a covalent bond or a spacer, and J is an end-group. In some embodiments, the spacer may comprise a structure such as:(I). Other aspects of the present invention generally relate to methods of using such articles, e.g., by exposing the article to a target molecule such as a protein, for example, for use in screening of particle-based peptide libraries. Still other aspects of the present invention generally relate to methods of making such articles, methods of promoting such articles, kits involving such articles, or the like.

Abstract translation: 本发明通常涉及各种肽和颗粒，例如用于筛选基于颗粒或珠的肽文库。 一方面，本发明一般涉及包含连接到一个或多个颗粒上的肽的制品，其可以具有诸如（颗粒）-MQ-Zn-XJ，（颗粒）-MQ-Zn-X1-X2-X3 -X4-X5-J，（颗粒）-MR-Zn-X1-X2-X3-X4-X5-J，（颗粒）-MR-X1-X2-X3-X4-X5Zn-QJ，（颗粒） -X1-X2-X-3X4-X5-Zn-RJ等，其中M是甲硫氨酸残基，M1是可切割的接头残基，Q是能够提高质谱强度和/或灵敏度的基团，X包括 一个或多个氨基酸残基，n为正整数，Z为共价键或间隔基，J为端基。 在一些实施方案中，间隔物可以包括如下结构：（I）。 本发明的其它方面通常涉及使用这种制品的方法，例如通过将制品暴露于靶分子例如蛋白质，例如用于筛选基于粒子的肽文库。 本发明的其它方面通常涉及制造这种制品的方法，促进这种制品的方法，涉及这种制品的试剂盒等。

公开(公告)号：US08026488B2

公开(公告)日：2011-09-27

申请号：US12358750

申请日：2009-01-23

Applicant: Yiran Zheng ,  Barry W. Wessels

Inventor： Yiran Zheng ,  Barry W. Wessels

IPC: G01T1/166

CPC classification number: A61B6/037 ,  G06T7/11 ,  G06T7/136 ,  G06T7/62 ,  G06T2207/10104 ,  G06T2207/20008 ,  G06T2207/30096

Abstract: A method for positive emission tomography (PET) target image segmentation is provided. The method comprises capturing and digitizing image data of a selected target, determining an initial concentration ratio based on an initial source background ratio and an initial volume estimate of the selected target employing a concentration ratio table, determining a desired threshold from the initial concentration ratio and the initial volume estimate employing a threshold table, and determining a final volume estimate of the selected target based on the determined desired threshold.

Abstract translation: 提供了一种用于正发射断层摄影（PET）目标图像分割的方法。 该方法包括捕获和数字化所选择的目标的图像数据，基于初始源背景比和使用浓度比表选择的目标的初始体积估计来确定初始浓度比，从初始浓度比确定期望阈值，以及 使用阈值表的初始体积估计，以及基于所确定的期望阈值来确定所选择的目标的最终体积估计。