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公开(公告)号：US06168942A
公开(公告)日：2001-01-02
申请号：US09433262
申请日：1999-11-04
Applicant: Xuemei Cao , Michael G. Sheppard
Inventor： Xuemei Cao , Michael G. Sheppard
IPC: C12N704
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
Abstract translation: 本发明涉及通过突变Npro蛋白酶基因产生减毒形式的牛病毒性腹泻（BVD）病毒的方法。 本发明包括通过该方法制备的减毒病毒，使用这些病毒产生的抗体，以及可用于免疫牛的疫苗。
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公开(公告)号：US20080305130A1
公开(公告)日：2008-12-11
申请号：US11995779
申请日：2006-11-24
Applicant: Chichi Huang , Michael G. Sheppard , Xuemei Cao , Gabriele M. Zybarth
Inventor： Chichi Huang , Michael G. Sheppard , Xuemei Cao , Gabriele M. Zybarth
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/55 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
Abstract: The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
Abstract translation: 本发明涉及包含至少一个解旋酶结构域氨基酸突变的牛病毒性腹泻病毒，其中NS3结构域中的突变导致针对野生型NS3产生的单克隆抗体的识别丧失，但是其中病毒RNA复制和 一代感染性病毒被保留。 本发明可用于例如产生标记的牛病毒性腹泻病毒疫苗或区分接种疫苗和感染或未接种疫苗的动物。
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公开(公告)号：US20080286302A1
公开(公告)日：2008-11-20
申请号：US12098015
申请日：2008-04-04
Applicant: Siao-Kun Wan Welsh , Jay Gregory Calvert , Michael K. O'Hara , Xuemei Cao
Inventor： Siao-Kun Wan Welsh , Jay Gregory Calvert , Michael K. O'Hara , Xuemei Cao
IPC: A61K39/155 , A61K39/12 , A61P31/12
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/53 , C12N2770/24322 , C12N2770/24334
Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
Abstract translation: 本发明提供了安全的疫苗和制备这种疫苗的方法。 本发明的疫苗含有至少两种相同家族的活突变病毒或编码这种病毒的核酸分子，其中两种病毒或编码核酸中的每一种都含有赋予所需表型的突变和病毒突变 位于相同的基因组位点，使得突变病毒不能彼此重组以消除突变。
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公开(公告)号：US20050053621A1
公开(公告)日：2005-03-10
申请号：US10893712
申请日：2004-07-16
Applicant: Siao-Kun Welch , Jay Calvert , Michael O'Hara , Xuemei Cao
Inventor： Siao-Kun Welch , Jay Calvert , Michael O'Hara , Xuemei Cao
IPC: A61K39/12 , A61K39/295 , C07K14/18
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/53 , C12N2770/24322 , C12N2770/24334
Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic adds contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
Abstract translation: 本发明提供了安全的疫苗和制备这种疫苗的方法。 本发明的疫苗含有至少两种相同家族的活突变病毒或编码这种病毒的核酸分子，其中两种病毒或编码核酸添加物中的每一种含有赋予所需表型的突变和病毒中的突变 位于相同的基因组位点，使得突变病毒不能彼此重组以消除突变。
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公开(公告)号：US20120021001A1
公开(公告)日：2012-01-26
申请号：US13165877
申请日：2011-06-22
Applicant: Chichi Huang , Michael G. Sheppard , Xuemei Cao , Gabriele M. Zybarth
Inventor： Chichi Huang , Michael G. Sheppard , Xuemei Cao , Gabriele M. Zybarth
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/55 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
Abstract: The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.
Abstract translation: 本发明涉及包含至少一个解旋酶结构域氨基酸突变的牛病毒性腹泻病毒，其中NS3结构域中的突变导致针对野生型NS3产生的单克隆抗体的识别丧失，但是其中病毒RNA复制和 一代感染性病毒被保留。 本发明可用于例如产生标记的牛病毒性腹泻病毒疫苗或区分接种疫苗和感染或未接种疫苗的动物。
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Patent Agency Ranking
公开(公告)号：US07754222B2
公开(公告)日：2010-07-13
申请号：US12098015
申请日：2008-04-04
Applicant: Siao-Kun Wan Welch , Jay Gregory Calvert , Michael K O'Hara , Xuemei Cao
Inventor： Siao-Kun Wan Welch , Jay Gregory Calvert , Michael K O'Hara , Xuemei Cao
IPC: A61K39/12 , A61K39/295
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/53 , C12N2770/24322 , C12N2770/24334
Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
Abstract translation: 本发明提供了安全的疫苗和制备这种疫苗的方法。 本发明的疫苗含有至少两种相同家族的活突变病毒或编码这种病毒的核酸分子，其中两种病毒或编码核酸中的每一种都含有赋予所需表型的突变和病毒突变 位于相同的基因组位点，使得突变病毒不能彼此重组以消除突变。
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7.发明授权Generation of type I/type II hybrid form of bovine viral diarrhea virus for use as vaccine 失效产生用作疫苗的牛病毒性腹泻病毒的I型/ II型杂交形式公开(公告)号：US06974575B2
公开(公告)日：2005-12-13
申请号：US10228406
申请日：2002-08-27
Applicant: Xuemei Cao , Gabriele M. Zybarth
Inventor： Xuemei Cao , Gabriele M. Zybarth
CPC classification number: C12N7/00 , A61K39/12 , A61K2039/525 , A61K2039/552 , C12N2770/24321 , C12N2770/24334
Abstract: The present invention provides genetically engineered type I/type II hybrid BVDV viruses. The hybrid viruses, as well as the hybrid viral genome, can be used in immunogenic compositions and vaccines for protecting cattle from BVDV infection.
Abstract translation: 本发明提供了基因工程的I型II型混合BVDV病毒。 杂交病毒以及杂交病毒基因组可用于免疫原性组合物和疫苗中，用于保护牛免受BVDV感染。
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公开(公告)号：US06410299B1
公开(公告)日：2002-06-25
申请号：US09649796
申请日：2000-08-29
Applicant: Xuemei Cao , Michael G. Sheppard
Inventor： Xuemei Cao , Michael G. Sheppard
IPC: C12N704
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
Abstract translation: 本发明涉及通过突变Npro蛋白酶基因产生减毒形式的牛病毒性腹泻（BVD）病毒的方法。 本发明包括通过该方法制备的减毒病毒，使用这些病毒产生的抗体，以及可用于免疫牛的疫苗。
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公开(公告)号：US06410032B1
公开(公告)日：2002-06-25
申请号：US09702330
申请日：2000-10-31
Applicant: Xuemei Cao , Michael G. Sheppard
Inventor： Xuemei Cao , Michael G. Sheppard
IPC: A61K39193
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by the method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
Abstract translation: 本发明涉及通过突变Npro蛋白酶基因产生减毒形式的牛病毒性腹泻（BVD）病毒的方法。 本发明包括通过该方法制备的减毒病毒，使用这些病毒产生的抗体，以及可用于免疫牛的疫苗。
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公开(公告)号：US07361357B2
公开(公告)日：2008-04-22
申请号：US10893712
申请日：2004-07-16
Applicant: Siao-Kun Wan Welch , Jay Gregory Calvert , Michael K. O'Hara , Xuemei Cao
Inventor： Siao-Kun Wan Welch , Jay Gregory Calvert , Michael K. O'Hara , Xuemei Cao
IPC: A61K39/12
CPC classification number: C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/53 , C12N2770/24322 , C12N2770/24334
Abstract: The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic adds contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.
Abstract translation: 本发明提供了安全的疫苗和制备这种疫苗的方法。 本发明的疫苗含有至少两种相同家族的活突变病毒或编码这种病毒的核酸分子，其中两种病毒或编码核酸添加物中的每一种含有赋予所需表型的突变和病毒中的突变 位于相同的基因组位点，使得突变病毒不能彼此重组以消除突变。
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