公开(公告)号：US20130042332A1

公开(公告)日：2013-02-14

申请号：US13507945

申请日：2012-08-08

Applicant: Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

Inventor： Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

IPC: A01K67/00 ,  F41B11/32 ,  A01K29/00 ,  F41B11/00

CPC classification number: A61B5/4064 ,  A01K29/00 ,  A22B3/02 ,  A61B5/1036 ,  A61B5/6803 ,  A61B2503/40 ,  A61B2562/0247 ,  F41B11/60 ,  G01L5/0052

Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

公开(公告)号：US06806261B2

公开(公告)日：2004-10-19

申请号：US10209011

申请日：2002-08-01

Applicant: Barbara S. Slusher ,  Xi-Chun May Lu ,  Krystyna Wozniak

Inventor： Barbara S. Slusher ,  Xi-Chun May Lu ,  Krystyna Wozniak

IPC: A61K31215

CPC classification number: A61K31/66 ,  A61K31/00

Abstract: The present invention relates to methods for regulating the release of TGF-&bgr; from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or for preventing or treating diabetes.

Abstract translation: 本发明涉及用于在体外或体内调节TGF-β从活细胞释放的方法，包括使细胞与有效量的NAALADase抑制剂接触。 据信这些方法可用于影响神经再生，细胞增殖，细胞分化，细胞外基质形成，髓鞘形成，炎症，免疫功能，肝功能，胰腺功能，血管生成或伤口愈合。 和/或用于预防或治疗糖尿病。

公开(公告)号：US08973565B2

公开(公告)日：2015-03-10

申请号：US13507945

申请日：2012-08-08

Applicant: Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

Inventor： Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

IPC: F41B11/32

CPC classification number: A61B5/4064 ,  A01K29/00 ,  A22B3/02 ,  A61B5/1036 ,  A61B5/6803 ,  A61B2503/40 ,  A61B2562/0247 ,  F41B11/60 ,  G01L5/0052

Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

Abstract translation: 在实验室动物身上造成脑损伤的装置和方法，该实验动物采用支撑实验室动物的平台。 平台定义了用于将实验室动物的头部定位在开口上的开口。 弹射器从位于平台开口下方的射弹发射装置发射。 射弹发射装置具有在所述平台的开口处和/或通过所述平台的开口直接推进射弹的手段，从而通过射弹的压力波或震荡冲击对动物造成脑部伤害。 没有头盔，射弹的直接影响会导致严重的创伤性脑损伤。 使用头盔保护动物免受颅骨骨折，硬膜下血肿，脑内出血和挫伤，但产生轻度脑震荡样病理。

公开(公告)号：US06444657B1

公开(公告)日：2002-09-03

申请号：US09425197

申请日：1999-10-22

Applicant: Barbara S. Slusher ,  Xi-Chun May Lu ,  Krystyna Wozniak

Inventor： Barbara S. Slusher ,  Xi-Chun May Lu ,  Krystyna Wozniak

IPC: A61K31095

CPC classification number: A61K31/66 ,  A61K31/00

Abstract: The present invention relates to methods of using NAALADase inhibitors to regulate TGF-&bgr; and to treat neurodegenerative disorders, extracellular matrix formation disorders, cell-growth related diseases, infectious diseases, immune related diseases, epithelial tissue scarring, collagen vascular diseases, fibroproliferative disorders, connective tissue disorders, inflammatory diseases, respiratory distress syndrome and infertility.

Abstract translation: 本发明涉及使用NAALADase抑制剂调节TGF-β并治疗神经变性疾病，细胞外基质形成障碍，细胞生长相关疾病，感染性疾病，免疫相关疾病，上皮组织瘢痕形成，胶原血管疾病，纤维增生性疾病， 结缔组织疾病，炎性疾病，呼吸窘迫综合征和不育症。

公开(公告)号：US07714020B2

公开(公告)日：2010-05-11

申请号：US11398032

申请日：2006-04-04

Applicant: Peter David Gluckman ,  Margaret Anne Brimble ,  Douglas Wilson ,  Frank Casper Tortella ,  Anthony Joseph Williams ,  Xi-Chun May Lu ,  Jed A. Hartings ,  Divina Gryder

Inventor： Peter David Gluckman ,  Margaret Anne Brimble ,  Douglas Wilson ,  Frank Casper Tortella ,  Anthony Joseph Williams ,  Xi-Chun May Lu ,  Jed A. Hartings ,  Divina Gryder

IPC: A61K31/401 ,  C07D207/16

CPC classification number: C07K5/0806 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/06026

Abstract: Aspects of this invention include the use of G-2MePE to treat patients with brain injury characterized by non-convulsive seizures. G-2MePE is useful in treating brain injuries caused by traumatic brain injury, stroke, hypoxia/ischemia and toxic injury.

Abstract translation: 本发明的方面包括使用G-2MePE治疗以非惊厥发作为特征的脑损伤患者。 G-2MePE可用于治疗创伤性脑损伤，中风，缺氧/缺血和中毒性损伤引起的脑损伤。

公开(公告)号：US20150057193A1

公开(公告)日：2015-02-26

申请号：US14120992

申请日：2014-09-26

Applicant: JITENDRA RAMANLAL DAVE ,  CHANGPING YAO ,  ANTHONY JOSEPH WILLIAMS ,  XI-CHUN MAY-LU ,  FRANK CASPER TORTELLA ,  KA-WANG KEVIN WAND ,  RONALD LAWRENCE HAYES

Inventor： JITENDRA RAMANLAL DAVE ,  CHANGPING YAO ,  ANTHONY JOSEPH WILLIAMS ,  XI-CHUN MAY-LU ,  FRANK CASPER TORTELLA ,  KA-WANG KEVIN WAND ,  RONALD LAWRENCE HAYES

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/52 ,  G01N2800/28 ,  G01N2800/2871

Abstract: A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP II) and comparing to a control. An increase of EMAP II indicates the presence of traumatic brain injury and a decrease of EMAP II indicates the presence of ischemic brain injury. Detection of EMAPII can be done in brain tissue, biofluids such as cerebrospinal fluid or blood (including plasma and serum)

Abstract translation: 通过检测内皮单核细胞活化多肽II（EMAP II）的表达水平并与对照进行比较，诊断脑损伤和脑损伤类型（创伤与缺血）的诊断工具和方法。 EMAP II的增加表明存在创伤性脑损伤，并且EMAP II的降低表明存在缺血性脑损伤。 EMAPII的检测可以在脑组织，生物流体如脑脊液或血液（包括血浆和血清）中进行，

公开(公告)号：US20140343458A1

公开(公告)日：2014-11-20

申请号：US14121045

申请日：2014-07-24

Applicant: Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

Inventor： Zhiyong Chen ,  Zhilin Liao ,  Frank C. Tortella ,  Xi-Chun May Lu ,  Jitendra R. Dave ,  Jay E. Bartlett ,  Mark F. Arnold ,  Mark P. Easterday ,  Mark W. Brown ,  Larry R. Holmes ,  Zachary J. Larimore ,  Kara E. Schmid ,  Deborah A. Shear ,  Lai Yee Leung ,  Andrea Mountney

IPC: A61B5/00 ,  G01L5/00 ,  A01K29/00

CPC classification number: A61B5/4064 ,  A01K29/00 ,  A22B3/02 ,  A61B5/1036 ,  A61B5/6803 ,  A61B2503/40 ,  A61B2562/0247 ,  F41B11/60 ,  G01L5/0052

Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

Abstract translation: 在实验室动物身上造成脑损伤的装置和方法，该实验动物采用支撑实验室动物的平台。 平台定义了用于将实验室动物的头部定位在开口上的开口。 弹射器从位于平台开口下方的射弹发射装置发射。 射弹发射装置具有在所述平台的开口处和/或通过所述平台的开口直接推进射弹的手段，从而通过射弹的压力波或震荡冲击对动物造成脑损伤。 没有头盔，射弹的直接影响会导致严重的创伤性脑损伤。 使用头盔保护动物免受颅骨骨折，硬膜下血肿，脑内出血和挫伤，但产生轻度脑震荡样病理。