公开(公告)号：US20090118302A1

公开(公告)日：2009-05-07

申请号：US11794564

申请日：2005-06-15

申请人： Young-Dae Gong ,  Jin-Soo Seo ,  Moon-Kook Jeon ,  Wei-Jong Kwak ,  Yong-Baik Cho ,  Nam Kyu Lee ,  Eun Ju Lee ,  Jung Bum Lee ,  Jun Won Lee ,  Sukho Lee ,  Mi-Sook Dong ,  Jeong-Ran Kim

发明人： Young-Dae Gong ,  Jin-Soo Seo ,  Moon-Kook Jeon ,  Wei-Jong Kwak ,  Yong-Baik Cho ,  Nam Kyu Lee ,  Eun Ju Lee ,  Jung Bum Lee ,  Jun Won Lee ,  Sukho Lee ,  Mi-Sook Dong ,  Jeong-Ran Kim

IPC分类号： A61K31/496 ,  C07D311/58 ,  A61K31/352 ,  A61P1/16 ,  A61P17/00 ,  A61P9/00 ,  A61P11/00 ,  A61K31/453 ,  C07D405/12

CPC分类号： C07D311/70

摘要： The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.

摘要翻译： 本发明涉及一种对TGF-β受体具有良好的拮抗作用的新型苯并吡喃衍生物，可有效地用作肝脏疾病的预防和治疗剂，以及若干纤维样天然酶，如肝纤维化，肝硬化，肺纤维化，皮肤硬化，肾小球 纤维化等; 及其药物用途。

公开(公告)号：US20070212408A1

公开(公告)日：2007-09-13

申请号：US11587720

申请日：2005-04-27

申请人： Nam Kim ,  Jin Choi ,  Jae Kim ,  Nam Lee ,  Je Ryu ,  Yong Hwang ,  Yong Oh ,  Dong Min ,  Key Um ,  Wei-Jong Kwak ,  Do Kum

发明人： Nam Kim ,  Jin Choi ,  Jae Kim ,  Nam Lee ,  Je Ryu ,  Yong Hwang ,  Yong Oh ,  Dong Min ,  Key Um ,  Wei-Jong Kwak ,  Do Kum

IPC分类号： A61K31/724 ,  C08B30/18 ,  A61K9/48 ,  A61K9/20

CPC分类号： B82Y5/00 ,  A61K47/6951

摘要： The present invention relates to an inclusion complex containing a benzimidazole derivative with excellent storage stability and a method of its preparation. In particular, the present invention relates to an inclusion complex containing a benzimidazole derivative with improved storage stability and a method of its preparation, where an inclusion complex is manufactured by performing an inclusion reaction by combining a benzimidazole derivative, cyclodextrin and a water-soluble polymer in an aqueous alkali solution in order to be formulated after stabilizing an acid-unstable benzimidazole derivative.

摘要翻译： 本发明涉及包含具有优异储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法。 特别地，本发明涉及包含具有改进的储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法，其中通过将苯并咪唑衍生物，环糊精和水溶性聚合物组合进行包合反应来制备包合络合物 在碱性水溶液中，为了在稳定酸不稳定的苯并咪唑衍生物后配制。