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1.发明申请Transgenic Mouse Models for Diseases Caused by mtDNA Mutations and Related Methods 失效mtDNA突变引起的疾病转基因小鼠模型及相关方法公开(公告)号：US20100169985A1
公开(公告)日：2010-07-01
申请号：US12205588
申请日：2008-09-05
CPC分类号： A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509
摘要： Animal models and methods wherein homoplasmic and heteroplasmic mtDNA mutation(s) are induced in an animal (e.g., a mouse) to cause or facilitate the development of a disorder (e.g., disease, malformation, defect, abnormality or other disorder). In at least some embodiments, the mtDNA mutation(s) will cause or facilitate the development of an age-related disorder, such as a cardiac disease, cardiomyopathy, muscle disease, cancer, abnormaly in tissues of high cellular turnover, heart dysfunction, graying of hair, alopecia, auditory function loss, cochlear degeneration, immune cell loss, anemia, male germ cell loss leading to lack of sperm and infertility, skeletal muscle mass loss (sarcopenia), neurodegeneration, increased presence of apoptotic markers, and loss of bone mass.
摘要翻译： 动物模型和方法，其中在动物（例如小鼠）中诱导同质和异质性mtDNA突变以引起或促进疾病（例如疾病，畸形，缺陷，异常或其他病症）的发展。 在至少一些实施方案中，mtDNA突变将引起或促进年龄相关疾病的发展，例如心脏病，心肌病，肌肉疾病，癌症，高细胞周转组织中的异常，心脏功能障碍，灰化 的头发，脱发，听觉功能丧失，耳蜗变性，免疫细胞丧失，贫血，男性生殖细胞损失导致精子和不孕不育，骨骼肌质量损失（肌肉减少），神经变性，凋亡标志物的增加和骨丢失 质量
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2.发明授权Transgenic mouse models for diseases caused by mtDNA mutations and related methods 失效由mtDNA突变引起的疾病的转基因小鼠模型及相关方法公开(公告)号：US08203030B2
公开(公告)日：2012-06-19
申请号：US12205588
申请日：2008-09-05
IPC分类号： G01N33/00 , A01K67/00 , A01K67/027
CPC分类号： A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509
摘要： Animal models and methods wherein homoplasmic and heteroplasmic mtDNA mutation(s) are induced in an animal (e.g., a mouse) to cause or facilitate the development of a disorder (e.g., disease, malformation, defect, abnormality or other disorder). In at least some embodiments, the mtDNA mutation(s) will cause or facilitate the development of an age-related disorder, such as a cardiac disease, cardiomyopathy, muscle disease, cancer, abnormaly in tissues of high cellular turnover, heart dysfunction, graying of hair, alopecia, auditory function loss, cochlear degeneration, immune cell loss, anemia, male germ cell loss leading to lack of sperm and infertility, skeletal muscle mass loss (sarcopenia), neurodegeneration, increased presence of apoptotic markers, and loss of bone mass.
摘要翻译： 动物模型和方法，其中在动物（例如小鼠）中诱导同质和异质性mtDNA突变以引起或促进疾病（例如疾病，畸形，缺陷，异常或其他病症）的发展。 在至少一些实施方案中，mtDNA突变将引起或促进年龄相关疾病的发展，例如心脏病，心肌病，肌肉疾病，癌症，高细胞周转组织中的异常，心脏功能障碍，灰化 的头发，脱发，听觉功能丧失，耳蜗变性，免疫细胞丧失，贫血，男性生殖细胞损失导致精子和不孕不育，骨骼肌质量损失（肌肉减少），神经变性，凋亡标志物的增加和骨丢失 质量
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