公开(公告)号：US20230338519A1

公开(公告)日：2023-10-26

申请号：US17998693

申请日：2021-05-14

Applicant: Transmed Gothenburg AB

Inventor： Nils Lycke ,  Mohammad Arabpour ,  Fredrik Höök

IPC: A61K39/39 ,  C07K16/28 ,  C07K14/28 ,  A61P37/04 ,  A61K39/145

CPC classification number: A61K39/39 ,  C07K16/2839 ,  C07K14/28 ,  A61P37/04 ,  A61K39/145 ,  C07K2317/622 ,  C07K2319/55 ,  A61K2039/505

Abstract: The present invention relates to a fusion protein, a nucleotide sequence encoding such a fusion protein, the use thereof as an adjuvant or vaccine. The fustin protein comprises a bacterial exotoxin and a single chain antibody fragment (scFv) that specifically binds to a surface marker on dendritic cells. The fusion protein is advantageously administered intranasally, orally or intrapulmonarily.