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公开(公告)号：US10701957B2
公开(公告)日：2020-07-07
申请号：US12675174
申请日：2008-08-29
IPC分类号： A23K20/179 , A61K8/99 , A61K31/122 , A61Q19/00 , C12P23/00 , A61K8/35 , C07C403/24 , C09B61/00 , A23L33/105 , A23L5/44 , A23L33/155
摘要： The present invention provides a composition comprising a high content of highly pure, low-cost, and safe carotenoid and a method for industrially producing the same. The present invention also provides functional food, a pharmaceutical composition and a cosmetic product comprising such a composition. The present invention further provides a method for producing a composition containing at least 80% of carotenoid, which is characterized in treating a microorganism culture with extraction using a lower alcohol at 80° C. at the lowest or a combination of water and a lower alcohol at 80° C. at the lowest, and then washing and filtrating the precipitate obtained from the extract solution with a combination of a lower alcohol and water.
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公开(公告)号：US20120004319A1
公开(公告)日：2012-01-05
申请号：US13203324
申请日：2010-03-01
IPC分类号： A61K31/122 , C07C49/573 , A61K8/35 , A61P43/00 , A61Q90/00 , C12P7/26 , C07C49/557
CPC分类号： C12R1/01 , A23L5/44 , A23L33/105 , A61K31/122 , C12P23/00
摘要： The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.
摘要翻译： 本发明提供一种含有类胡萝卜素的组合物的制造方法，包括以下步骤：使用水溶性有机溶剂对产生类胡萝卜素的微生物的培养物进行萃取处理; 将得到的提取液分散在水中进行胶束化; 在溶剂中加热搅拌得到的胶束化溶液使胶束破裂并沉淀出目的类胡萝卜素成分，得到沉淀物; 用乙醇收集和洗涤沉淀物; 并进一步对沉淀物进行粉碎/干燥; 食品，药物组合物和含有类胡萝卜素的组合物的化妆品。
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公开(公告)号：US20100291251A1
公开(公告)日：2010-11-18
申请号：US12675174
申请日：2008-08-29
摘要： The present invention provides a composition comprising a high content of highly pure, low-cost, and safe carotenoid and a method for industrially producing the same. The present invention also provides functional food, a pharmaceutical composition and a cosmetic product comprising such a composition. The present invention further provides a method for producing a composition containing at least 80% of carotenoid, which is characterized in treating a microorganism culture with extraction using a lower alcohol at 80° C. at the lowest or a combination of water and a lower alcohol at 80° C. at the lowest, and then washing and filtrating the precipitate obtained from the extract solution with a combination of a lower alcohol and water.
摘要翻译： 本发明提供包含高含量的高纯度，低成本和安全的类胡萝卜素的组合物及其工业生产方法。 本发明还提供功能食品，药物组合物和包含这种组合物的化妆品。 本发明还提供一种制备含有至少80％的类胡萝卜素的组合物的方法，其特征在于在80℃下使用低级醇或最低水或低级醇的组合处理微生物培养物 在最低的80℃下，然后用低级醇和水的组合洗涤并过滤从萃取液中得到的沉淀物。
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公开(公告)号：US20100174118A1
公开(公告)日：2010-07-08
申请号：US12294762
申请日：2007-03-28
IPC分类号： C07C49/713 , C12P7/26
摘要： A method for producing a composition containing carotenoid at a content of 80% or greater, characterized in performing extraction on a culture of a microorganism, a concentrate of the culture, or a dried substance thereof with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, lower dialkylketones and ethers; and then washing a precipitate, obtained by concentrating the extract solution, with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, hydrocarbon-based solvents and lower dialkylketones; and food, a pharmaceutical composition or a cosmetic substance comprising the carotenoid-containing composition.
摘要翻译： 一种含有80％以上的含有类胡萝卜素的组合物的制造方法，其特征在于，对微生物的培养物，培养物的浓缩物或其干燥物质进行萃取，所述方法中选自下组 醇，含水低级醇，低级二烷基酮和醚; 然后用选自低级醇，含水低级醇，烃系溶剂和低级二烷基酮中的至少一种来洗涤通过浓缩萃取液而得到的沉淀物; 食品，含有类胡萝卜素的组合物的药物组合物或化妆品。
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公开(公告)号：US08097761B2
公开(公告)日：2012-01-17
申请号：US12294762
申请日：2007-03-28
IPC分类号： C07C45/00
摘要： A method for producing a composition containing carotenoid at a content of 80% or greater, characterized in performing extraction on a culture of a microorganism, a concentrate of the culture, or a dried substance thereof with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, lower dialkylketones and ethers; and then washing a precipitate, obtained by concentrating the extract solution, with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, hydrocarbon-based solvents and lower dialkylketones; and food, a pharmaceutical composition or a cosmetic substance comprising the carotenoid-containing composition.
摘要翻译： 一种含有80％以上的含有类胡萝卜素的组合物的制造方法，其特征在于，对微生物的培养物，培养物的浓缩物或其干燥物质进行萃取，所述方法中选自下组 醇，含水低级醇，低级二烷基酮和醚; 然后用选自低级醇，含水低级醇，烃系溶剂和低级二烷基酮中的至少一种来洗涤通过浓缩萃取液而得到的沉淀物; 食品，含有类胡萝卜素的组合物的药物组合物或化妆品。
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公开(公告)号：US08524289B2
公开(公告)日：2013-09-03
申请号：US13203324
申请日：2010-03-01
IPC分类号： A01N65/00
CPC分类号： C12R1/01 , A23L5/44 , A23L33/105 , A61K31/122 , C12P23/00
摘要： The present invention provides a method for producing a carotenoid-containing composition, comprising the steps of: subjecting a culture of a carotenoid-producing microorganism to an extraction treatment using a water-soluble organic solvent; dispersing the resulting extract solution in water for micellization; heat stirring the resulting micellized solution in a solvent break the micelles and precipitate the carotenoid component of interest to obtain the precipitate; collecting and heat washing the precipitate with ethanol; and further subjecting the precipitate to pulverization/drying; and food, a pharmaceutical composition and a cosmetic product comprising the carotenoid-containing composition.
摘要翻译： 本发明提供一种含有类胡萝卜素的组合物的制造方法，包括以下步骤：使用水溶性有机溶剂对产生类胡萝卜素的微生物的培养物进行萃取处理; 将得到的提取液分散在水中进行胶束化; 在溶剂中加热搅拌得到的胶束化溶液使胶束破裂并沉淀出目的类胡萝卜素成分，得到沉淀物; 用乙醇收集和洗涤沉淀物; 并进一步对沉淀物进行粉碎/干燥; 食品，药物组合物和含有类胡萝卜素的组合物的化妆品。
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