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公开(公告)号：US20070007959A1
公开(公告)日：2007-01-11
申请号：US11474249
申请日：2006-06-23
申请人： Thomas Szyperski , David Parish
发明人： Thomas Szyperski , David Parish
IPC分类号： G01V3/00
CPC分类号： G01R33/4616
摘要： The present invention discloses a method of simultaneously conducting more than one step of a radiofrequency phase cycle in a nuclear magnetic resonance (NMR) experiment. The method first involves providing a sample. Next, one or more radiofrequency pulses are applied to a plurality of spatially discrete slices of the sample under conditions effective to simultaneously conduct more than one step of a radiofrequency phase cycle in a single transient. Then, NMR signals generated from the step of applying the radiofrequency pulses are acquired. Finally, the NMR signals are processed to obtain an NMR spectrum.
摘要翻译： 本发明公开了一种在核磁共振（NMR）实验中同时进行射频相循环的一个以上步骤的方法。 该方法首先涉及提供样品。 接下来，在有效同时在单个瞬态中同时进行射频相位循环的多个步骤的条件下，将一个或多个射频脉冲施加到样本的多个空间上离散的片段。 然后，获取从施加射频脉冲的步骤产生的NMR信号。 最后，对NMR信号进行处理以获得NMR光谱。
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2.发明申请METHODS OF USING COMBINED FORWARD AND BACKWARD SAMPLING OF NUCLEAR MAGNETIC RESONANCE TIME DOMAIN FOR MEASUREMENT OF SECONDARY PHASE SHIFTS, DETECTION OF ABSORPTION MODE SIGNALS DEVOID OF DISPERSIVE COMPONENTS, AND/OR OPTIMIZATION OF NUCLEAR MAGNETIC RESONANCE EXPERIMENTS 失效使用组合前向和后向采样核磁共振时域测量二次相移的方法，检测吸收模式信号分离分量，和/或优化核磁共振实验公开(公告)号：US20090230959A1
公开(公告)日：2009-09-17
申请号：US12370303
申请日：2009-02-12
申请人： Thomas Szyperski , Arindam Ghosh , Yibing Wu
发明人： Thomas Szyperski , Arindam Ghosh , Yibing Wu
IPC分类号： G01R33/44
CPC分类号： G01R33/4633 , G01N24/087
摘要： The present invention relates to a method of conducting an N-dimensional nuclear magnetic resonance (NMR) experiment in a phase-sensitive manner by the use of forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure time domain amplitudes and secondary phase shifts. The present invention also relates to methods of conducting an N-dimensional NMR experiment in a phase-sensitive manner by the use of dual forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure secondary phase shifts or at least partially cancel dispersive and quadrature image signal components arising in the frequency domain from secondary phase shifts.
摘要翻译： 本发明涉及一种以相敏方式进行N维核磁共振（NMR）实验的方法，通过使用有效测量时域的条件下的主相移偏移的时域的正向和反向采样 幅度和次级相移。 本发明还涉及以相敏方式进行N维NMR实验的方法，该方法通过在有效测量第二相移的条件下使用在主相位偏移的时域的双向正向和反向取样，至少 部分地从第二相移中消除在频域中产生的色散和正交图像信号分量。
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3.发明申请G-matrix Fourier transformation (GFT) nuclear magnetic resonance (NMR) experiments for resonance assignment and structure determination of organic molecules 失效用于共振分配和有机分子结构测定的G-基质傅里叶变换（GFT）核磁共振（NMR）实验公开(公告)号：US20060111846A1
公开(公告)日：2006-05-25
申请号：US11253262
申请日：2005-10-18
IPC分类号： G06F19/00
CPC分类号： G01R33/4633 , G01N24/087 , G01R33/465 , G06F19/16
摘要： The present invention discloses a suite of G2FT and GFT NMR experiments that can be used for complete resonance assignments of proteins and for obtaining structural (conformational and orientational) constraints for determining high resolution three-dimensional structures of biomolecules.
摘要翻译： 本发明公开了一套可用于蛋白质的完全共振分配和用于获得用于确定高分辨率三维结构的结构（构象和取向）约束的G＆amp; 2 FT和GFT NMR实验， 生物分子。
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4.发明申请METHODS FOR GENERATING PREDICTIVE MODELS FOR EPITHELIAL OVARIAN CANCER AND METHODS FOR IDENTIFYING EOC 审中-公开用于产生上皮癌的预测模型的方法和识别EOC的方法公开(公告)号：US20140156573A1
公开(公告)日：2014-06-05
申请号：US14234728
申请日：2012-07-27
IPC分类号： G06F19/00
CPC分类号： G16H50/20 , G01R33/4625 , G01R33/465
摘要： A method for generating a model for epithelial ovarian cancer is presented, comprising the steps of obtaining a mass spectrum for each of a plurality of samples, segmenting each of the mass spectra into “bins,” and determining a plurality of relationships between two or more bins. One are more statistically significant factors are identified according to the determined plurality of relationships, and a predictive model is generated as a function of the one or more identified factors. A method of the present invention may further comprise the step of obtaining one or more nuclear magnetic resonance spectra of each of the samples, which are segmented into a plurality of bins. Combinations of mass spectra and NMR spectra may be used to determine the plurality of relationships. In other embodiments, methods for identifying the presence of EOC indicated by a biological sample of an individual are presented.
摘要翻译： 提出了一种用于产生上皮性卵巢癌模型的方法，包括以下步骤：获得多个样本中的每个样本的质谱，将每个质谱分割成“箱”，并确定两个或更多个之间的多个关系 箱子。 一个是根据确定的多个关系识别的更具统计意义的因素，并且根据一个或多个识别的因素生成预测模型。 本发明的方法还可以包括获得每个样品的一个或多个核磁共振谱的步骤，其被分段成多个箱体。 可以使用质谱和NMR光谱的组合来确定多个关系。 在其他实施方案中，提供了用于鉴定由个体的生物样品指示的EOC的存在的方法。
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公开(公告)号：US07586306B2
公开(公告)日：2009-09-08
申请号：US12181857
申请日：2008-07-29
申请人： Thomas Szyperski , David Parish
发明人： Thomas Szyperski , David Parish
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , A61B5/7257
摘要： The present invention relates to a method for simultaneously conducting multiple steps of a cycle of a nuclear magnetic resonance (NMR) experiment without the use of pulsed magnetic field gradients during signal detection in which one or more spatially selective radiofrequency pulses are applied to a sample under conditions effective to simultaneously spatially distribute the radiofrequency power associated with each of the cycle steps to a plurality of spatially discrete sections within the sample such that each section executes an individual step of the cycle and the resultant NMR signals from each of the cycle steps are produced simultaneously.
摘要翻译： 本发明涉及一种用于在信号检测期间不使用脉冲磁场梯度同时进行核磁共振（NMR）实验的循环的多个步骤的方法，其中一个或多个空间选择性射频脉冲施加到样品下 有效地将与每个循环步骤相关联的射频功率同时空间分配到样本内的多个空间上离散的部分的条件，使得每个部分执行该循环的单独步骤，并且产生来自每个循环步骤的所得NMR信号 同时。
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6.发明申请Method of using G-matrix fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins 失效使用G矩阵傅里叶变换核磁共振（GFT NMR）光谱法进行蛋白质快速化学位移分配和二级结构测定的方法公开(公告)号：US20050114038A1
公开(公告)日：2005-05-26
申请号：US10973807
申请日：2004-10-26
申请人： Thomas Szyperski , Seho Kim , Hanudatta Atreya
发明人： Thomas Szyperski , Seho Kim , Hanudatta Atreya
IPC分类号： G01R33/46 , G01R33/465 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01R33/4633 , G01R33/465 , Y10T436/24
摘要： The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named “GFT NMR spectroscopy”, which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the “sampling limited” data collection regime. Concomitantly, the analysis of the resulting checmical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.
摘要翻译： 本发明提供了一种快速获得精确的高维NMR光谱信息的新方法，命名为“GFT NMR光谱”，其基于跨过常规NMR实验的子空间的间接尺寸的相敏联合采样。 与FT NMR相比，高维NMR实验的几个间接尺寸的相敏联合取样导致最大测量时间大大降低。 这样可以避免“采样受限”的数据收集制度。 伴随地，通过G矩阵变换编辑的所得到的移动多重点的分析产生了用于化学位移测量的增加的精度。 此外，公开了进行特定GFT NMR实验的方法以及进行GFT NMR实验的组合以快速获得精确的化学位移分配和确定蛋白质或其他分子的结构的方法。
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7.发明授权Methods of using combined forward and backward sampling of nuclear magnetic resonance time domain for measurement of secondary phase shifts, detection of absorption mode signals devoid of dispersive components, and/or optimization of nuclear magnetic resonance experiments 失效使用核磁共振时域的正向和反向采样的组合来测量二次相移的方法，检测没有色散分量的吸收模式信号的检测和/或核磁共振实验的优化公开(公告)号：US08248071B2
公开(公告)日：2012-08-21
申请号：US12370303
申请日：2009-02-12
申请人： Thomas Szyperski , Arindam Ghosh , Yibing Wu
发明人： Thomas Szyperski , Arindam Ghosh , Yibing Wu
IPC分类号： G01V3/00
CPC分类号： G01R33/4633 , G01N24/087
摘要： The present invention relates to a method of conducting an N-dimensional nuclear magnetic resonance (NMR) experiment in a phase-sensitive manner by the use of forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure time domain amplitudes and secondary phase shifts. The present invention also relates to methods of conducting an N-dimensional NMR experiment in a phase-sensitive manner by the use of dual forward and backward sampling of time domain shifted by a primary phase shift under conditions effective to measure secondary phase shifts or at least partially cancel dispersive and quadrature image signal components arising in the frequency domain from secondary phase shifts.
摘要翻译： 本发明涉及一种以相敏方式进行N维核磁共振（NMR）实验的方法，通过使用有效测量时域的条件下的主相移偏移的时域的正向和反向采样 幅度和次级相移。 本发明还涉及以相敏方式进行N维NMR实验的方法，该方法通过在有效测量第二相移的条件下使用在主相位偏移的时域的双向正向和反向取样，至少 部分地从第二相移中消除在频域中产生的色散和正交图像信号分量。
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公开(公告)号：US20090033326A1
公开(公告)日：2009-02-05
申请号：US12181857
申请日：2008-07-29
申请人： Thomas Szyperski , David Parish
发明人： Thomas Szyperski , David Parish
IPC分类号： G01R33/48
CPC分类号： A61B5/055 , A61B5/7257
摘要： The present invention relates to a method for simultaneously conducting multiple steps of a cycle of a nuclear magnetic resonance (NMR) experiment without the use of pulsed magnetic field gradients during signal detection in which one or more spatially selective radiofrequency pulses are applied to a sample under conditions effective to simultaneously spatially distribute the radiofrequency power associated with each of the cycle steps to a plurality of spatially discrete sections within the sample such that each section executes an individual step of the cycle and the resultant NMR signals from each of the cycle steps are produced simultaneously.
摘要翻译： 本发明涉及一种用于在信号检测期间不使用脉冲磁场梯度同时进行核磁共振（NMR）实验的循环的多个步骤的方法，其中一个或多个空间选择性射频脉冲施加到样品下 有效地将与每个循环步骤相关联的射频功率同时空间分配到样本内的多个空间上离散的部分的条件，使得每个部分执行该循环的单独步骤，并且产生来自每个循环步骤的所得NMR信号 同时。
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