公开(公告)号：US20070135395A1

公开(公告)日：2007-06-14

申请号：US10588800

申请日：2005-03-23

Applicant: Erik Hansen ,  Thomas Sabroe ,  Martin Calverley ,  Henrik Pedersen ,  Heinz-Josef Deussen

Inventor： Erik Hansen ,  Thomas Sabroe ,  Martin Calverley ,  Henrik Pedersen ,  Heinz-Josef Deussen

IPC: A61K31/59 ,  C07C401/00

CPC classification number: C07C401/00 ,  C07C2601/02 ,  C07D333/72

Abstract: The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

Abstract translation: 本发明涉及制备可用于合成卡波头三醇的中间体的新方法。 本发明进一步涉及用所述方法生产卡培三酚或卡泊三醇一水合物生产的中间体的用途。

公开(公告)号：US20070027333A1

公开(公告)日：2007-02-01

申请号：US10549315

申请日：2005-03-10

Applicant: Thomas Sabroe ,  Martin Calverley

Inventor： Thomas Sabroe ,  Martin Calverley

IPC: C07C401/00 ,  C07D333/64

CPC classification number: C07C401/00 ,  C07C2601/02 ,  C07D333/72

Abstract: The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

Abstract translation: 本发明涉及可用于合成卡泊三醇或卡泊​​三醇一水合物的中间体，制备所述中间体的方法以及立体选择性还原所述中间体的方法。