公开(公告)号：US08766875B2

公开(公告)日：2014-07-01

申请号：US13476764

申请日：2012-05-21

申请人： Robert Brett Williams ,  Kyle W. Maxhimer ,  Larry L. Lai ,  Thomas Brennan ,  Clifton Quan ,  Fangchou Yang

发明人： Robert Brett Williams ,  Kyle W. Maxhimer ,  Larry L. Lai ,  Thomas Brennan ,  Clifton Quan ,  Fangchou Yang

IPC分类号： H01Q15/14 ,  H01Q1/28

CPC分类号： H01Q15/144 ,  H01Q1/28 ,  H01Q19/106 ,  H01Q21/0087 ,  H01Q21/061

摘要： An integrated stiffener and RF reflector (stiffener/reflector) (100) for a RF emitter which includes: a plurality of vertical ribs (102) constituting side walls of the stiffener/reflector; a plurality of horizontal ribs (104) formed in a width direction of the stiffener/reflector; a top cover (204) including metallization layer (308), the top cover being electrically coupled to a ground layer (312) of the RF emitter and configured in such a way to direct all of RF energy in an opposite direction to the top cover. Each of the vertical (102) and horizontal (104) ribs has a sandwich structure, which includes: a foam core layer (302) disposed on a layer of the RF emitter (314); a thin film layer (306) bonded to sides and top of the rib to form facesheets of the sandwich structure.

摘要翻译： 用于RF发射器的集成加强件和RF反射器（加强件/反射器）（100），其包括：构成加强件/反射器的侧壁的多个垂直肋条（102） 在加强件/反射器的宽度方向上形成的多个水平肋（104） 包括金属化层（308）的顶盖（204），所述顶盖电耦合到所述RF发射器的接地层（312），并且被配置为以与顶盖相反的方向引导所有RF能量 。 垂直（102）和水平（104）肋中的每一个具有夹层结构，其包括：布置在RF发射器（314）的层上的泡沫芯层（302）; 粘合到所述肋的侧面和顶部的薄膜层（306），以形成所述夹层结构的面板。

公开(公告)号：US20060212480A1

公开(公告)日：2006-09-21

申请号：US11085813

申请日：2005-03-21

申请人： Steven Lundberg ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha ,  Thomas Brennan

发明人： Steven Lundberg ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha ,  Thomas Brennan

IPC分类号： G06F17/00

CPC分类号： G06Q10/10

摘要： Method and apparatus are disclosed for managing intellectual property information including organizing intellectual property data in a data processing system according to file clusters. A method comprises organizing intellectual property data in an intellectual property data management system, wherein the management system tracks events and data related to a plurality of patent matters processed by one or more government agencies and owned by at least one patent owner. Representations of the patent matters are entered into a data structure in the data management system. A user of the data management system can selectively associate patent matters together into clusters wherein the clusters have names and wherein at least one of a plurality of clusters maintained in the system can be located and viewed. One of the matters associated with the cluster can be selected and the data of the matter viewed or processed by a user. Further, the clusters can be organized and categorized so that selected users can not view the clusters.

摘要翻译： 公开了用于管理知识产权信息的方法和装置，包括根据文件簇在数据处理系统中组织知识产权数据。 一种方法包括在知识产权数据管理系统中组织知识产权数据，其中管理系统跟踪由一个或多个政府机构处理并由至少一个专利所有者拥有的与多个专利事务有关的事件和数据。 专利事务的陈述被输入数据管理系统的数据结构。 数据管理系统的用户可以选择性地将专利事项关联到群集中，其中群集具有姓名，并且其中可以定位和查看系统中维护的多个群集中的至少一个。 可以选择与集群相关的事项之一，以及用户查看或处理的事项的数据。 此外，可以组织和分类集群，使得所选择的用户不能查看集群。

公开(公告)号：US20060206345A1

公开(公告)日：2006-09-14

申请号：US11062119

申请日：2005-02-18

申请人： Steven Lundberg ,  Thomas Brennan ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha

发明人： Steven Lundberg ,  Thomas Brennan ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha

IPC分类号： G06Q99/00

CPC分类号： G06Q10/00 ,  G06Q50/184

摘要： There is disclosed method and apparatus for downloading private intellectual property information from a first secured data source maintained by a government agency, wherein access to the private intellectual property information is secured with one or more security mechanisms, and storing at least some of the downloaded information into a first data management system accessible to a first group of users specified by a law firm. At least some of the downloaded information is copied into a second data management system accessible to a second group of users specified by a corporation represented by the law firm. An intellectual property management system is maintained and includes data associated with a plurality of intellectual property matters and data associated with a plurality of intellectual property events occurring relative to the matters, wherein the events originate from a government agency and further wherein the intellectual property matters indicated in the management system are managed at least in part by a legal representative. The private intellectual property information is downloaded from a first secured data source maintained by the government agency, wherein the information relates to intellectual property matters that the secured data source indicates are related at least in part with the legal representative, and access to the private intellectual property information is secured with one or more security mechanisms associated with the legal representative. The system further automatically compares at least some of the downloaded information with data maintained in the intellectual property management system to determine discrepancies between the intellectual property matters indicated in the management system as related to the legal representative and intellectual property matters indicated in the secured data source as associated with the legal representative.

摘要翻译： 公开了一种从由政府机构维护的第一安全数据源下载私人知识产权信息的方法和装置，其中利用一个或多个安全机制保护对私有知识产权信息的访问，并且存储至少一些所下载的信息 成为由律师事务所指定的第一组用户可访问的第一个数据管理系统。 至少一些下载的信息被复制到由律师事务所代理的公司指定的第二组用户可访问的第二数据管理系统中。 维护知识产权管理系统，并包括与多个知识产权相关的数据和与相关事宜相关的多个知识产权事件相关的数据，其中事件源于政府机构，其中知识产权事项表明 在管理体系中至少部分由法定代表人管理。 私人知识产权信息是从政府机构维护的第一个安全数据源中下载的，其中所述信息涉及安全数据源表明的知识产权问题至少部分与法定代表人相关，并且访问私人知识产权 财产信息由与法定代表人相关联的一个或多个安全机制确保。 该系统进一步自动将所下载的信息中的至少一些与维护在知识产权管理系统中的数据进行比较，以确定管理系统中指出的与法定代表人有关的知识产权事项与安全数据源中指出的知识产权事项之间的差异 与法定代表人有关。

公开(公告)号：US20060190495A1

公开(公告)日：2006-08-24

申请号：US11061385

申请日：2005-02-18

申请人： Steven Lundberg ,  Thomas Brennan ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha

发明人： Steven Lundberg ,  Thomas Brennan ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha

IPC分类号： G06F17/30

CPC分类号： G06Q10/10

摘要： There is disclosed method and apparatus for storing and processing information in a data storage and processing system used by attorneys, and recording attorney-client communications and communications from a government agency respecting a legal matter. At least some of the attorney-client communications can be designated with a indication that allows them to be identified automatically. These communications can then be automatically identifying and purging at least some of the attorney-client communications upon a request by a user.

摘要翻译： 公开了用于在律师使用的数据存储和处理系统中存储和处理信息的方法和装置，并且从法律事务的政府机构记录律师和客户的通信和通信。 至少一些律师 - 客户端通信可以被指定为允许自动识别的指示。 然后，根据用户的请求，这些通信可以自动识别和清除至少一些律师 - 客户端通信。

公开(公告)号：US08685931B2

公开(公告)日：2014-04-01

申请号：US13515429

申请日：2010-12-17

申请人： Thomas Brennan ,  Robert Dean ,  W. Michael Kavanaugh ,  Janine Powers

发明人： Thomas Brennan ,  Robert Dean ,  W. Michael Kavanaugh ,  Janine Powers

IPC分类号： A61K38/00 ,  A61P17/14 ,  A61P35/00 ,  C07K14/515

CPC分类号： C07K14/71 ,  A61K8/64 ,  A61K31/473 ,  A61K31/506 ,  A61K38/179 ,  A61Q7/00

摘要： The present invention relates to a method of promoting hair growth comprising administering a fibroblast growth factor receptor 3 (FGFR3) extracellular domain (ECD), including native FGFR3 ECDs, variants, fragments, and fusion molecules, to a subject in an amount sufficient to promote hair growth.

摘要翻译： 促进毛发生长的方法本发明涉及一种促进毛发生长的方法，包括以足以促进毛发生长的量施用包含天然FGFR3 ECDs，变体，片段和融合分子的成纤维细胞生长因子受体3（FGFR3）细胞外结构域（ECD） 头发生长。

公开(公告)号：US08431532B2

公开(公告)日：2013-04-30

申请号：US13169900

申请日：2011-06-27

申请人： Thomas Brennan ,  Ernestine Lee ,  Steven Smith

发明人： Thomas Brennan ,  Ernestine Lee ,  Steven Smith

IPC分类号： A61K38/17

CPC分类号： A61K38/17 ,  C07K14/71 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/42

摘要： Methods of treatment using Fzd8 extracellular domains (ECDs), Fzd8 ECD fusion molecules, and/or antibodies that bind Fzd8 are provided. Such methods include, but are not limited to, methods of treating obesity and obesity-related conditions. Fzd8 ECDs and Fzd8 ECD fusion molecules are also provided. Polypeptide and polynucleotide sequences, vectors, host cells, and compositions comprising or encoding such molecules are provided. Methods of making and using Fzd8 ECDs, Fzd8 ECD fusion molecules, and antibodies that bind Fzd8 are also provided.

摘要翻译： 提供了使用Fzd8细胞外结构域（ECD），Fzd8 ECD融合分子和/或结合Fzd8的抗体的治疗方法。 这些方法包括但不限于治疗肥胖症和肥胖相关病症的方法。 还提供Fzd8 ECDs和Fzd8 ECD融合分子。 提供了多肽和多核苷酸序列，载体，宿主细胞和包含或编码这些分子的组合物。 还提供了制备和使用Fzd8 ECDs，Fzd8 ECD融合分子和结合Fzd8的抗体的方法。

公开(公告)号：US20070107075A1

公开(公告)日：2007-05-10

申请号：US11464453

申请日：2006-08-14

申请人： Robert Klein ,  Thomas Brennan

发明人： Robert Klein ,  Thomas Brennan

IPC分类号： A01K67/027 ,  C12N5/06

CPC分类号： A01K67/0276 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/20 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0356 ,  A01K2267/0393 ,  A61K38/00 ,  C07K14/705 ,  C12N15/8509

摘要： The present invention relates to compositions and methods relating to the characterization and function of GABRR2. Specifically, the present invention provides transgenic animals and methods of treating disease states or conditions in which the GABRR2 is implicated. The present invention also provides agents and method of identifying agents that modulate GABRR2. Such agents may be useful in treating and preventing conditions associated with pain.

摘要翻译： 本发明涉及与GABRR2的表征和功能相关的组合物和方法。 具体地说，本发明提供转基因动物和治疗其中涉及GABRR2的疾病状态或病症的方法。 本发明还提供了鉴定调节GABRR2的试剂的试剂和方法。 这些药剂可用于治疗和预防与疼痛相关的病症。

公开(公告)号：US20070054851A1

公开(公告)日：2007-03-08

申请号：US11442244

申请日：2006-05-30

申请人： Junyu Lin ,  Srinivas Kothakota ,  Ge Wu ,  Stephen Doberstein ,  Thomas Brennan ,  Lorianne Masuoka ,  Minmin Qin ,  Shannon Marshall ,  Yan Wang ,  Diane Hollenbaugh ,  Lewis Williams

发明人： Junyu Lin ,  Srinivas Kothakota ,  Ge Wu ,  Stephen Doberstein ,  Thomas Brennan ,  Lorianne Masuoka ,  Minmin Qin ,  Shannon Marshall ,  Yan Wang ,  Diane Hollenbaugh ,  Lewis Williams

IPC分类号： A61K38/18

CPC分类号： A61K38/1883 ,  A61K31/155 ,  A61K31/18 ,  A61K31/195 ,  A61K31/197 ,  A61K38/1808 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K2300/00

摘要： The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity.

摘要翻译： 本发明涉及ErbB配体（包括β细胞素）的治疗用途。 治疗用途包括单独使用ErbB配体家族化合物或与其它药物联合用于降低血糖水平，治疗I型和II型糖尿病，肥胖症，肌肉消瘦疾病和心脏毒性的方法。

公开(公告)号：US20060271893A1

公开(公告)日：2006-11-30

申请号：US11138835

申请日：2005-05-26

申请人： Thomas Brennan ,  Todd Greenfield

发明人： Thomas Brennan ,  Todd Greenfield

IPC分类号： G06F17/50

CPC分类号： G06F17/505 ,  G06F17/5036

摘要： A method of modifying an integrated circuit design. A noise threshold is determined. A threshold, noisy wire length for a particular integrated circuit design is selected. An integrated circuit design is examined for problem networks or wires and all branches that cumulatively equal or exceed the designated threshold noisy wire length. Once the problem networks are identified, the driver circuits driving the problem networks are temporarily replaced with driver circuits with lesser driving capacity. The integrated circuit design is then tested and any new timing failures are identified. Networks that include new timing failures are isolated with symmetric and/or asymmetric wire configurations. This method of modifying an integrated circuit design is non-intrusive to existing neighboring wires, and thus the timing in existing wires is preserved.

摘要翻译： 一种修改集成电路设计的方法。 确定噪声阈值。 选择特定集成电路设计的阈值，噪声线长度。 检查问题网络或电线以及累积等于或超过指定阈值噪声线长度的所有分支的集成电路设计。 一旦识别出问题网络，驱动问题网络的驱动电路就暂时用较小驱动能力的驱动电路替代。 然后测试集成电路设计，并确定任何新的定时故障。 包括新的定时故障的网络通过对称和/或不对称的线路配置隔离开来。 这种修改集成电路设计的方法对现有的相邻导线是非侵入性的，因此保留现有导线中的定时。

公开(公告)号：US20060212788A1

公开(公告)日：2006-09-21

申请号：US11085814

申请日：2005-03-21

申请人： Steven Lundberg ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha ,  Thomas Brennan

发明人： Steven Lundberg ,  Janal Kalis ,  Shal Jain ,  Pradeep Sinha ,  Thomas Brennan

IPC分类号： G06F17/00

CPC分类号： G06Q10/00

摘要： Method and apparatus for organizing intellectual property data according to activities related to intellectual property are disclosed, wherein each activity is represented by an activity data structure containing at least some data pertinent to the activity. A plurality of docket items are associated with intellectual property deadlines, and at least some of the docket items are associated with at least one activity data structure. A plurality of activity data structures are made accessible through a user interface display in which an indication of one or more activity data structures are displayed. At least one view of an activity data structure shows docket items associated with the activity data structure. The activity data structure is represented in a display of more than one indication of data structures showing a date selected from the group of: a date attribute of the activity or a date attribute of an IP docket item associated with the activity.

摘要翻译： 公开了根据与知识产权有关的活动来组织知识产权数据的方法和装置，其中每个活动由包含与该活动相关的至少一些数据的活动数据结构表示。 多个文件项目与知识产权期限相关联，并且至少一些文件项目与至少一个活动数据结构相关联。 多个活动数据结构可通过其中显示一个或多个活动数据结构的指示的用户界面显示来访问。 活动数据结构的至少一个视图显示与活动数据结构相关联的记录项。 活动数据结构以显示从以下组中选择的日期的数据结构的多于一个指示的显示来表示：活动的日期属性或与活动相关联的IP档案项的日期属性。