公开(公告)号：US07974669B2

公开(公告)日：2011-07-05

申请号：US11572960

申请日：2005-07-26

申请人： Akihide Kitamura ,  Fumio Nomura ,  Takashi Karatsu

发明人： Akihide Kitamura ,  Fumio Nomura ,  Takashi Karatsu

IPC分类号： A61B5/00

CPC分类号： G01N21/3577

摘要： The objective of the present invention is to provide a method and instrument for measuring glucose concentration in blood using infrared spectroscopy. Glucose concentration in blood is measured based on an integrated value obtained by measuring an absorption spectrum that includes the wavenumber range of 1020-1040 cm−1, and by integrating the intensity of absorption of the wavenumber range of 1020-1040 cm−1 within the absorption spectrum. Alternatively, a glucose concentration in blood is measured based on an integrated value through measuring an absorption spectrum including the wavenumber range of 1010-1050 cm31 1; obtaining a second-derivative spectrum by calculating a second derivative of the absorption spectrum that includes the wavenumber range of 1010-1050 cm−1 in the absorption spectrum; determining an integration range based on the second derivative spectrum; and then obtaining the integrated value by integrating the intensity of absorption based on this determined integration range.

摘要翻译： 本发明的目的是提供一种使用红外光谱测量血液中葡萄糖浓度的方法和仪器。 基于通过测量包含1020-1040cm -1的波数范围的吸收光谱获得的积分值，并且通过将1020-1040cm -1的波数范围的吸收强度积分在 吸收光谱。 或者，通过测量包括1010-1050cm31的波数范围的吸收光谱，基于积分值来测量血液中的葡萄糖浓度; 通过计算吸收光谱中包含1010-1050cm -1的波数范围的吸收光谱的二次导数，得到二阶导数光谱; 基于二阶导数谱确定积分范围; 然后通过基于该确定的积分范围积分吸收强度来获得积分值。

公开(公告)号：US20090004682A1

公开(公告)日：2009-01-01

申请号：US11572960

申请日：2005-07-26

申请人： Akihide Kitamura ,  Fumio Nomura ,  Takashi Karatsu

发明人： Akihide Kitamura ,  Fumio Nomura ,  Takashi Karatsu

IPC分类号： C12Q1/54 ,  C12M1/34

CPC分类号： G01N21/3577

摘要： The objective of the present invention is to provide a method and instrument for measuring glucose concentration in blood using infrared spectroscopy. Glucose concentration in blood is measured based on an integrated value obtained by measuring an absorption spectrum that includes the wavelength range of 1020-1040 cm−1, and by integrating the intensity of absorption of the wavelength range of 1020-1040 cm−1 within the absorption spectrum. Alternatively, a glucose concentration in blood is measured based on an integrated value through measuring an absorption spectrum including the wavelength range of 1010-1050 cm−1; obtaining a second-derivative spectrum by calculating a second derivative of the absorption spectrum that includes the wavelength range of 1010-1050 cm−1 in the absorption spectrum; determining an integration range based on the second derivative spectrum; and then obtaining the integrated value by integrating the intensity of absorption based on this determined integration range.

摘要翻译： 本发明的目的是提供一种使用红外光谱测量血液中葡萄糖浓度的方法和仪器。 基于通过测量包含1020-1040cm -1的波长范围的吸收光谱而获得的积分值，并且通过将1020-1040cm -1的波长范围的吸收强度积分到内部，测量血液中的葡萄糖浓度 吸收光谱。 或者，通过测量包括1010-1050cm -1的波长范围的吸收光谱，基于积分值来测量血液中的葡萄糖浓度; 通过计算吸收光谱中包含1010-1050cm-1的波长范围的吸收光谱的二次导数来获得二阶导数光谱; 基于二阶导数谱确定积分范围; 然后通过基于该确定的积分范围积分吸收强度来获得积分值。