公开(公告)号：US20060281875A1

公开(公告)日：2006-12-14

申请号：US11441138

申请日：2006-05-26

Applicant: Takao Uno ,  Kenichi Takita ,  Susumu Sekiguchi

Inventor： Takao Uno ,  Kenichi Takita ,  Susumu Sekiguchi

IPC: C08L83/08 ,  C08G77/24

CPC classification number: C08L83/08 ,  Y10T428/31663 ,  C08L83/00 ,  C08L2666/28 ,  C08L2666/54

Abstract: A fluorosilicone rubber composition is provided comprising (A) a first organopolysiloxane having the formula: R1aR2bR3cSiO(4-a-b-c)/2 wherein R1 is trifluoropropyl, R2 is an aliphatic unsaturated hydrocarbon group, R3 is an aliphatic saturated hydrocarbon or aromatic hydrocarbon group, (B) a silica filler, (C) a second organopolysiloxane having formula (2) wherein R4 is an aliphatic unsaturated hydrocarbon group or the like, and (D) a cure catalyst. The fluorosilicone rubber composition affords satisfactory adhesion at the interface with dimethylsilicone rubber even when the molding pressure is low.

Abstract translation: 提供了氟硅橡胶组合物，其包含（A）具有下式的第一有机聚硅氧烷：R 1， （4-abc）/ 2其中R 1是三氟丙基，R 1，R 2，R 3， 2是脂族不饱和烃基，R 3是脂族饱和烃或芳族烃基，（B）二氧化硅填料，（C）具有式（2）的第二有机聚硅氧烷，其中 R 4是脂肪族不饱和烃基等，（D）固化催化剂。 即使成型压力低，氟硅酮橡胶组合物在与二甲基硅酮橡胶的界面上也具有令人满意的粘合性。

公开(公告)号：US08779142B2

公开(公告)日：2014-07-15

申请号：US13378527

申请日：2010-07-09

Applicant: Makoto Kitade ,  Shuichi Ohkubo ,  Chihoko Yoshimura ,  Satoshi Yamashita ,  Hiromi Oshiumi ,  Takao Uno ,  Yuichi Kawai

Inventor： Makoto Kitade ,  Shuichi Ohkubo ,  Chihoko Yoshimura ,  Satoshi Yamashita ,  Hiromi Oshiumi ,  Takao Uno ,  Yuichi Kawai

IPC: A61K31/4365 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D209/08 ,  C07D519/00

Abstract: It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.

Abstract translation: 旨在提供表现出HSP90抑制活性和细胞增殖抑制作用的新型氮杂双环化合物。 具体公开的是由下列通式（I）表示的化合物或其盐：其中X1表示CH或N; X2，X3和X4中的任一个表示N，其余的表示CH; Y 1，Y 2，Y 3和Y 4中的任何一个或两个表示C-R 4，其余的相同或不同，表示CH或N; R1表示具有1至4个选自N，S和O的杂原子的任选取代的单环或双环不饱和杂环基; R2表示碳原子数1〜6的烷基等。 R3和R4表示-CO-R5等。

公开(公告)号：US20120108589A1

公开(公告)日：2012-05-03

申请号：US13378527

申请日：2010-07-09

Applicant: Makoto Kitade ,  Shuichi Ohkubo ,  Chihoko Yoshimura ,  Satoshi Yamashita ,  Hiromi Oshiumi ,  Takao Uno ,  Yuichi Kawai

Inventor： Makoto Kitade ,  Shuichi Ohkubo ,  Chihoko Yoshimura ,  Satoshi Yamashita ,  Hiromi Oshiumi ,  Takao Uno ,  Yuichi Kawai

IPC: A61K31/437 ,  A61K31/5377 ,  A61P35/00 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D209/08 ,  C07D519/00

Abstract: It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.

Abstract translation: 旨在提供表现出HSP90抑制活性和细胞增殖抑制作用的新型氮杂双环化合物。 具体公开的是由下列通式（I）表示的化合物或其盐：其中X1表示CH或N; X2，X3和X4中的任一个表示N，其余的表示CH; Y 1，Y 2，Y 3和Y 4中的任何一个或两个表示C-R 4，其余的相同或不同，表示CH或N; R1表示具有1至4个选自N，S和O的杂原子的任选取代的单环或双环不饱和杂环基; R2表示碳原子数1〜6的烷基等。 R3和R4表示-CO-R5等。

公开(公告)号：US07510772B2

公开(公告)日：2009-03-31

申请号：US11441138

申请日：2006-05-26

Applicant: Takao Uno ,  Kenichi Takita ,  Susumu Sekiguchi

Inventor： Takao Uno ,  Kenichi Takita ,  Susumu Sekiguchi

IPC: B32B9/04 ,  C08G77/24

CPC classification number: C08L83/08 ,  Y10T428/31663 ,  C08L83/00 ,  C08L2666/28 ,  C08L2666/54

Abstract: A fluorosilicone rubber composition is provided comprising (A) a first organopolysiloxane having the formula: R1aR2bR3cSiO(4-a-b-c)/2 wherein R1 is trifluoropropyl, R2 is an aliphatic unsaturated hydrocarbon group, R3 is an aliphatic saturated hydrocarbon or aromatic hydrocarbon group, (B) a silica filler, (C) a second organopolysiloxane having formula (2) wherein R4 is an aliphatic unsaturated hydrocarbon group or the like, and (D) a cure catalyst. The fluorosilicone rubber composition affords satisfactory adhesion at the interface with dimethylsilicone rubber even when the molding pressure is low.

Abstract translation: 提供一种氟硅橡胶组合物，其包含（A）具有下式的第一有机聚硅氧烷：R1aR2bR3cSiO（4-abc）/ 2其中R1是三氟丙基，R2是脂族不饱和烃基，R3是脂族饱和烃或芳烃基团（ B）二氧化硅填料，（C）具有式（2）的第二有机聚硅氧烷，其中R 4是脂族不饱和烃基等，和（D）固化催化剂。 即使成型压力低，氟硅酮橡胶组合物在与二甲基硅酮橡胶的界面上也具有令人满意的粘合性。