公开(公告)号：US20250059281A1

公开(公告)日：2025-02-20

申请号：US18598013

申请日：2024-03-07

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Margaret Ackerman ,  Casey Hua ,  Charles Sentman

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/46

Abstract: Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.

公开(公告)号：US20250058520A1

公开(公告)日：2025-02-20

申请号：US18685671

申请日：2022-08-22

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： William SCHEIDELER ,  Julia HUDDY

IPC: B29C64/30 ,  B33Y40/20 ,  C23C16/34 ,  C23C16/40 ,  C23C16/455

Abstract: A 3D printed, complex polymer structure can include a seed layer on the polymer structure. A thin film can be disposed on the seed layer. The seed layer can be an oxide, a nitride, or an oxynitride. The thin film can be an oxide, dielectric, semiconductor, or conductor. The polymer structure can be a lattice structure, cantilever, beam, or other shapes.

公开(公告)号：US12230437B2

公开(公告)日：2025-02-18

申请号：US18137051

申请日：2023-04-20

Applicant: Trustees of Dartmouth College

Inventor： Bradley A. Reese ,  Ulrike G. K. Wegst ,  Charles R. Sullivan

IPC: H01F41/02 ,  B22F1/068 ,  B22F1/10 ,  B22F3/00 ,  B22F3/22 ,  H01F7/02

Abstract: In an embodiment, the present disclosure pertains to a method of making a composite. In some embodiments, the method includes applying an external magnetic field to a mixture composed of a plurality of magnetic materials in a container, in which the external magnetic field produces a homogenous and uniform magnetic flux in the container. In some embodiments, the method further includes solidifying the mixture to result in the growth of solvent crystals in the mixture, and subliming a solvent phase of the mixture in the container to thereby form a composite having uniformly aligned magnetic materials. In an additional embodiment, the present disclosure pertains to a composite having uniformly aligned magnetic materials. In some embodiments, a majority of the magnetic materials in the composite are aligned in the same direction.

公开(公告)号：US12220434B2

公开(公告)日：2025-02-11

申请号：US17664156

申请日：2022-05-19

Applicant: Trustees of Dartmouth College ,  Dartmouth-Hitchcock Clinic

Inventor： George A. O'Toole ,  Juliette C. Madan

IPC: A61K35/745 ,  A61K35/741 ,  A61K35/744 ,  A61K45/06 ,  A61P1/00 ,  A61P11/00

Abstract: The present disclosure relates to a method of altering intestinal microbiome in a patient having cystic fibrosis comprising administering at least one of Bifidobacterium and/or Bacteroides to a patient and allowing the Bifidobacterium and/or Bacteroides to alter the intestinal microbiome.

公开(公告)号：US12196894B2

公开(公告)日：2025-01-14

申请号：US17796488

申请日：2021-01-29

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE ,  DOSEOPTICS, LLC

Inventor： Petr Bruza ,  Brian Pogue ,  Venkataramanan Krishnaswamy

IPC: G01T1/02 ,  G01T1/22 ,  G06T5/50 ,  H04N25/76

Abstract: A Cherenkov imaging system includes a high-speed radiation detector configured to provide a first timing signal synchronized with pulses of radiation to control operation of at least one pulse-gated, multiple-pulse-integrating, (PG-MPI) CMOS camera synchronized through the digital time signal to pulses of the radiation beam source, to image Cherenkov radiation; and a digital image-processing system. The high-speed radiation detector is either a solid-state radiation detector or a scintillator with a photodetector. The system images Cherenkov light emitted by tissue by using a timing signal synchronized to pulses of a pulsed radiation beam to control the PG-MPI camera by integrating light received by the PG-MPI camera during multiple pulses of the radiation beam while excluding light received by the camera between pulses of the radiation beam.

公开(公告)号：US20250009279A1

公开(公告)日：2025-01-09

申请号：US18893673

申请日：2024-09-23

Applicant: The Trustees of Dartmouth College

Inventor： David W. ROBERTS ,  Keith D. PAULSEN ,  Alexander HARTOV ,  Songbai JI ,  Xiaoyao FAN

IPC: A61B5/377 ,  A61B5/00 ,  A61B5/055 ,  A61B5/369 ,  A61B34/10 ,  A61B90/00 ,  G06T3/14 ,  G06T7/33 ,  H04N13/239 ,  H04N13/257

Abstract: A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

公开(公告)号：US20240426974A1

公开(公告)日：2024-12-26

申请号：US18749826

申请日：2024-06-21

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Beatrice Perez ,  Timothy Pierson ,  Gregory Mazzaro ,  David Kotz

IPC: G01S7/28 ,  G01S13/04 ,  G01S13/76

Abstract: A harmonic radar system for detecting an electronic device includes a signal generator for generating one or more transmit radio frequency (RF) signals, a transmitting antenna for sending the transmit RF signals into an environment, a receiving antenna for receiving signals reflected or re-radiated by the electronic device in the environment in response to the transmit RF signals, and a spectrum analyzer for identifying a harmonic frequency of the transmit RF signals in the filtered signals.

公开(公告)号：US12168780B2

公开(公告)日：2024-12-17

申请号：US16872438

申请日：2020-05-12

Applicant: TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles L. Sentman

IPC: A61P35/00 ,  A61K35/17 ,  A61K39/00 ,  C12N5/0783 ,  A61K35/12

Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.

公开(公告)号：US20240409643A1

公开(公告)日：2024-12-12

申请号：US18621312

申请日：2024-03-29

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： William G. NORTH

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: The disclosure provides anti-NMDAR2B agents such as anti-NMDAR2B antibodies (Abs), antigen-binding Ab fragments, multi-specific Abs and antigen-binding Ab fragments, antibody-drug conjugates (ADCs), and chimeric antigen receptors (CARs). The disclosure also provides polynucleotides and vectors encoding, cells and pharmaceutical compositions comprising such anti-NMDAR2B agents and/or polynucleotides. The present disclosure further relates to methods of treating a subject using such anti-NMDAR2B agents and compositions, and to methods of treating, preventing, or diagnosing a disease such as cancer and methods of stimulating an immune response. Also provided are methods of producing such anti-NMDAR2B agents and cells.

公开(公告)号：US12146158B2

公开(公告)日：2024-11-19

申请号：US18492221

申请日：2023-10-23

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Charles L. Sentman

IPC: A61K35/12 ,  A61K39/00 ,  C12N5/0783

Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.