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11 条记录 (耗时 0.01 秒)

    Novel 2-(3-trifluoromethylanilino)-benzoic acid compounds
    3.
    发明授权
    Novel 2-(3-trifluoromethylanilino)-benzoic acid compounds 失效
    新的2-（3-三氟甲基苯胺基） - 苯甲酸化合物

    公开(公告)号：US3897482A

    公开(公告)日：1975-07-29

    申请号：US20692371

    申请日：1971-12-10

    申请人： TROPONWERKE DINKLAGE & CO

    发明人： BOLTZE KARL-HEINZ ,  BRENDLER OTFRIED ,  DELL HANS-DIETER ,  JACOBI HAIREDDIN

    IPC分类号： C07C103/30

    摘要： Novel 2-(3-trifluoromethylanilino)-benzoic acid compounds of the formula

    wherein X is

    or a valence bond, and R is hydrogen or lower alkyl having from one to four carbon atoms have antiphlogistic properties and are substantially free of undesirable side effects.

    摘要翻译： 新颖的2-（3-三氟甲基苯胺基） - 苯甲酸化合物，其分子式为O和并联CX-NH-CH2-COR NH |，其中X为O并原-O-CH2-C-或价键，R为氢或低级 具有1-4个碳原子的烷基具有消炎特性并且基本上没有不期望的副作用。

    1-(3-(AMINO ALKYL)-2-OXO-2H-1-benzopyran-7-yl)-ureas
    7.
    发明授权
    1-(3-(AMINO ALKYL)-2-OXO-2H-1-benzopyran-7-yl)-ureas 失效
    1-（3-（氨基烷基）-2-氧代-2H- 1,1-苯并吡喃-7-基） - 脲

    公开(公告)号：US3897426A

    公开(公告)日：1975-07-29

    申请号：US16311072

    申请日：1972-07-15

    申请人： TROPONWERKE DINKLAGE & CO

    发明人： BECKER KARL HEINZ ,  BOLTZE KARL-HEINZ ,  DELL HANS-DIETER ,  SEIDEL PETER-RUDOLF

    IPC分类号： C07D311/08 ,  C07D311/16 ,  C07D87/42

    CPC分类号： C07D311/16 ,  Y10S514/929

    摘要： Compounds having the general formula (I)

    and salts thereof with physiologically acceptable acids, in which R1, R2, R5 and R6 represent hydrogen atoms, straight-chain or branched-chain alkyl groups with up to 4 carbon atoms, cycloalkyl, aralkyl, aryl groups or the radicals R1 and R2, and/or radicals R5 and R6, when taken together with the adjacent nitrogen atom represent heterocyclic compounds with 3 to 7 ring members of which 1 to 3 can be hetero atoms, providing that R1, R2 and R5 and R6 can be the same or different radicals, and also the groups -NR1R2 and -NR5R6 can be the same or different, R4 represents a hydrogen atom or a lower alkyl group with up to 3 carbon atoms, R7 represents a hydrogen atom, a lower alkyl group with up to 3 carbon atoms or an aryl group, Z represents a halogen atom, a lower alkyl or alkoxy group with up to 3 carbon atoms, N REPRESENTS A NUMBER FROM 0 TO 2, AND U represents a straight-chain or branched-chain lower alkylene group with 2 to 5 carbon atoms in which a hydrogen atom can be replaced by a hydroxyl group. These compounds have utility as coronary dilatators.

    摘要翻译： 具有通式（I）的化合物及其盐与生理上可接受的酸，其中R 1，R 2，R 5和R 6表示氢原子，具有至多4个碳原子的直链或支链烷基，环烷基，芳烷基，芳基 基团R 1和R 2和/或基团R 5和R 6与相邻的氮原子一起表示杂环化合物，其中3至7个环成员，其中1至3个可以是杂原子，条件是R1，R2和R5 并且R 6可以相同或不同，基团-NR 1 R 2和-NR 5 R 6可以相同或不同，R 4表示氢原子或具有至多3个碳原子的低级烷基，R 7表示氢原子， 具有至多3个碳原子的低级烷基或芳基，Z表示卤素原子，具有至多3个碳原子的低级烷基或烷氧基，N表示0至2个，U表示直链或 具有2至5个碳原子的支链低级亚烷基 氢原子可被羟基取代。

    Medicinal mixture for alleviation of painful conditions and method for using same
    8.
    发明授权
    Medicinal mixture for alleviation of painful conditions and method for using same 失效
    用于调理保湿条件的药物混合物及其使用方法

    公开(公告)号：US3662073A

    公开(公告)日：1972-05-09

    申请号：US3662073D

    申请日：1969-04-24

    申请人： TROPONWERKE DINKLAGE & CO

    发明人： LORENZ DIETRICH

    IPC分类号： A61K31/38 ,  A61K27/00

    CPC分类号： A61K31/38 ,  A61K31/215 ,  A61K31/495 ,  A61K2300/00

    摘要： A COMPOSITION COMPRISING (+)-1-BENXYL-3-DIMETHYLAMINO-2-METHYL-1-PHENYLPROPYLPROPIONATE (I) ADMIXED WITH A COMPOUND SELECTED FROM THE GROUP CONSISTING OF 2-CHLORO-9-($ - DINETHYLAMINOPROPYLIDENE)-THIOXANTHENE (II), 2 - CHLORO-9-(3-(N''-B-HYDROXYETHYLPIPRAZINO)-PROPYLIDENE)-THIOXANTHENE (III) AND 2-TRIFLUOROMETHY-9-(3(N''-B-HYDROXYETHYLPIPERAZINO)-PROPLIDENE)-THIOXANTHENE (IV). SPECIFIC COMPOSITIONS ARE THOSE IN WHICH THE WEIGHT RATIOS OF THE COMPONENTS AND IN THE CASE OF I AND II, AND I AND III, FROM 1:1 TO 64:1, AND IN THE CASE OF I AND IV FROM 1:1 TO 200:1. THE COMPOSITIONS MAY BE ADMINISTERED IN DOSAGE UNIT FORM. THE ANALGESIC EFFECT OF I AND II, III OR IV IS MORE THAN ADDITIVE, BUT THE SEDATIVE EFFECT OF II, III OR IV IS NOT SUBSTANTIALLY AFFECTED.

    Coumarine derivatives and process for the preparation thereof
    9.
    发明授权
    Coumarine derivatives and process for the preparation thereof 失效
    香豆素衍生物及其制备方法

    公开(公告)号：US3930003A

    公开(公告)日：1975-12-30

    申请号：US45092574

    申请日：1974-03-13

    申请人： TROPONWERKE DINKLAGE & CO

    发明人： BECKER KARL HEINZ ,  BOLTZE KARL-HEINZ ,  DELL HANS-DIETER ,  SEIDEL PETER-RUDOLF

    IPC分类号： C07D311/16 ,  A61K31/535

    CPC分类号： C07D311/16 ,  Y10S514/929

    摘要： and salts thereof with physiologically acceptable acids, in which R1, R2, R5 and R6 represent hydrogen atoms, straight-chain or branched-chain alkyl groups with up to 4 carbon atoms, cycloalkyl, aralkyl, aryl groups or the radicals R1 and R2, and/or radicals R5 and R6, when taken together with the adjacent nitrogen atom represent heterocyclic compounds with 3 to 7 ring members of which 1 to 3 can be hetero atoms, providing that R1, R2 and R5 and R6 can be the same or different radicals, and also the groups -NR1R2 and -NR5R6 can be the same or different, R4 represents a hydrogen atom or a lower alkyl group with up to 3 carbon atoms, R7 represents a hydrogen atom, a lower alkyl group with up to 3 carbon atoms or an aryl group, Z represents a halogen atom, a lower alkyl or alkoxy group with up to 3 carbon atoms, N represents a number from 0 to 2, and U represents a straight-chain or branched-chain lower alkylene group with 2 to 5 carbon atoms in which a hydrogen atom can be replaced by a hydroxyl group. These compounds have utility as coronary dilators.
    Compounds having the general formula (I)

    摘要翻译： 具有通式（I）的化合物及其盐与生理上可接受的酸，其中R 1，R 2，R 5和R 6表示氢原子，具有至多4个碳原子的直链或支链烷基，环烷基，芳烷基，芳基 基团R 1和R 2和/或基团R 5和R 6与相邻的氮原子一起表示杂环化合物，其中3至7个环成员，其中1至3个可以是杂原子，条件是R1，R2和R5 并且R 6可以相同或不同，基团-NR 1 R 2和-NR 5 R 6可以相同或不同，R 4表示氢原子或具有至多3个碳原子的低级烷基，R 7表示氢原子， 具有至多3个碳原子的低级烷基或芳基，Z表示卤素原子，具有至多3个碳原子的低级烷基或烷氧基，N表示0至2的数，U表示直链或 具有2至5个碳原子的支链低级亚烷基 氢原子可被羟基取代。 这些化合物可用作冠状动脉扩张器。

    Pharmacologically active esters and amides of n-{8 3-trifluoromethylphenyl{9 -anthranilic acid
    10.
    发明授权
    Pharmacologically active esters and amides of n-{8 3-trifluoromethylphenyl{9 -anthranilic acid 失效
    N- {8,3-三氟甲基苯基{9-壬二酸的药理学活性酯和氨基

    公开(公告)号：US3694489A

    公开(公告)日：1972-09-26

    申请号：US3694489D

    申请日：1970-07-16

    申请人： TROPONWERKE DINKLAGE & CO

    发明人： BOLTZE KARL-HEINZ ,  BRENDLER OTFRIED ,  LORENZ DIETRICH

    IPC分类号： A61K31/245 ,  A61P29/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/18 ,  C07C229/58 ,  C07C103/16

    CPC分类号： A61K31/245

    摘要： Compounds of the general formula

    IN WHICH N IS 0, 1 OR 2 AND R represents a hydroxyl group, a low molecular weight straight chained or branched alkoxy group in which the alkyl radical may have individual hydrogen atoms replaced by hydroxyl groups, an amino group or a low molecular weight straight chained or branched mono- or dialkylamino group in which individual hydrogen atoms of the alkyl groups may be replaced by hydroxyl groups. These compounds have a marked antiinflammatory effect and reduced side effects.

    摘要翻译： 通式为其中N为0,1或2的化合物，R为羟基，低分子量的直链或支链烷氧基，其中烷基可具有被羟基取代的单个氢原子，氨基或 低分子量的直链或支链单 - 或二烷基氨基，其中烷基的单个氢原子可以被羟基取代。