公开(公告)号：US12215095B2

公开(公告)日：2025-02-04

申请号：US17291707

申请日：2019-11-07

Applicant: Tianli Biotech Pty Ltd

Inventor： Alastair Stewart ,  Spencer Williams ,  Zalihe Hakki

IPC: C07D403/04 ,  A61P11/00 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

Abstract: The present invention relates to new compounds that are useful in the prevention or treatment of respiratory diseases, such as asthma, acute and chronic inflammatory conditions, and fibrotic diseases or conditions in which fibrosis contributes to the pathology of the condition. The invention also relates to the preparation of the compounds, and to compositions including the compounds. The present invention also relates to the use of the compounds, as well as compositions including the compounds, in treating or preventing respiratory diseases, acute and chronic inflammatory conditions, and fibrotic diseases or conditions in which fibrosis contributes to the pathology of the condition.

公开(公告)号：US11975005B2

公开(公告)日：2024-05-07

申请号：US18087672

申请日：2022-12-22

Applicant: TIANLI BIOTECH PTY LTD

Inventor： Alastair Stewart ,  Christine Keenan ,  Trudi Harris

IPC: C07D403/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61P35/00 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

CPC classification number: A61K31/519 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  A61K31/58 ,  A61K2300/00 ,  A61K31/573 ,  A61K2300/00 ,  A61K31/4439 ,  A61K2300/00 ,  A61K31/444 ,  A61K2300/00 ,  A61K31/506 ,  A61K2300/00 ,  A61K31/519 ,  A61K2300/00

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs. The present invention also provides a method of treating or preventing a condition of the airway or lung involving fibrosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1 or an inhibitor of ALK5, thereby treating or preventing a condition of the airway or lung involving fibrosis in a subject.

公开(公告)号：US20240245690A1

公开(公告)日：2024-07-25

申请号：US18627415

申请日：2024-04-04

Applicant: TIANLI BIOTECH PTY LTD

Inventor： Alastair Stewart ,  Christine Keenan ,  Trudi Harris

IPC: A61K31/519 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

CPC classification number: A61K31/519 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs. The present invention also provides a method of treating or preventing a condition of the airway or lung involving fibrosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1 or an inhibitor of ALK5, thereby treating or preventing a condition of the airway or lung involving fibrosis in a subject.