公开(公告)号：US07985856B2

公开(公告)日：2011-07-26

申请号：US11874697

申请日：2007-10-18

Applicant: Shang-Cheng Hung ,  Cheng-Chung Wang ,  Jinq Chyi Lee ,  Shun Yuan Luo ,  Suvarn Subhash Kulkarni ,  Yu Wen Huang ,  Chia Chen Lee ,  Ken Lien Chang

Inventor： Shang-Cheng Hung ,  Cheng-Chung Wang ,  Jinq Chyi Lee ,  Shun Yuan Luo ,  Suvarn Subhash Kulkarni ,  Yu Wen Huang ,  Chia Chen Lee ,  Ken Lien Chang

IPC: C07H1/00 ,  C07G3/00 ,  C07H15/04

CPC classification number: C07H1/00 ,  Y02P20/55

Abstract: A method for preparing hexose derivatives comprises the steps of providing a silylated hexose, treating the silylated hexose with a first carbonyl compound in the presence of a catalyst to form an ketalized hexose, treating the ketalized hexose with a second carbonyl compound followed by treating with a first reductant to form an etherized hexose, and converting the etherized hexose into a target hexose derivative, which can be 2-alcohol hexose, 3-alcohol hexose, 4-alcohol hexose, or a 6-alcohol hexose. In particular, the present invention can prepare the hexose derivatives with highly regioselective scheme to protect individual hydroxyls of monosaccharide units and install an orthogonal protecting group pattern in a one-pot manner.

Abstract translation: 制备己糖衍生物的方法包括以下步骤：提供甲硅烷基化己糖，在催化剂存在下用第一羰基化合物处理甲硅烷基己糖以形成缩酮化己糖，用第二羰基化合物处理缩醛己糖，接着用 首先还原剂形成醚化的己糖，并将醚化的己糖转化成目标己糖衍生物，其可以是2-醇己糖，3-醇己糖，4-醇己糖或6-醇己糖。 特别地，本发明可以制备具有高度区域选择性方案的己糖衍生物，以保护单糖单元的单个羟基并以一锅方式安装正交保护基团图案。