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    1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines
    1.
    发明授权
    1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines 失效
    1-苯基硫丙基-4-羟基-4-苯基哌啶

    公开(公告)号：US3960873A

    公开(公告)日：1976-06-01

    申请号：US481796

    申请日：1974-06-21

    Applicant: Isamu Maruyama ,  Hisao Yamamoto ,  Masaru Nakao ,  Shigeru Sakai ,  Kikuo Sasajima ,  Sumio Kitagawa ,  Shigeho Inaba

    Inventor： Isamu Maruyama ,  Hisao Yamamoto ,  Masaru Nakao ,  Shigeru Sakai ,  Kikuo Sasajima ,  Sumio Kitagawa ,  Shigeho Inaba

    IPC: C07D295/092 ,  C07D211/52

    CPC classification number: C07D295/088

    Abstract: Novel N-substituted heterocyclic derivatives represented by the formula, ##SPC1##Wherein R.sub.1 is hydrogen atom, lower alkyl, lower alkoxy, nitro, halogen or trifluoromethyl group; R.sub.2 is hydrogen atom or lower alkyl group; X is sulfur atom, sulfinyl or sulfonyl group; Y is ##EQU1## group (wherein R.sub.3 is phenyl or substituted phenyl group; R.sub.4 is hydrogen atom, hydroxy, lower alkyl, lower alkoxy, lower alkanoyl, lower alkanoyloxy, carbamoyl, N-(lower alkyl)-carbamoyl or N,N-di(lower akyl)-carbamoyl group; R.sub.5 is hydrogen atom, morpholino, pyrrolidinyl, piperidinyl, hexamethylenimino, lower alkyl, cyclo(lower alkyl), cyclo(lower alkyl)-(lower alkyl), hydroxy-(lower alkyl), (lower alkoxy)-(lower alkyl), phenyl or substituted phenyl group; k is 0 or 1 and m is 0, 1 or 2); and n is 3 or 4, and pharmaceutically acceptable salts thereof, which have excellent tranquillizing, anti-psychotonic, anti-emotional, anti-convulsive, anti-psychosis, sedative, analgesic or anti-hypertensive activities.

    Abstract translation: 由式WHEREIN R1表示的新型N-取代的杂环衍生物是氢原子，低级烷基，低级烷氧基，硝基，卤素或三氟甲基; R2是氢原子或低级烷基; X是硫原子，亚磺酰基或磺酰基; Y是|| - （CH2）kN-（CH2）m-R3， - （CH2）kC-（CH2）m-R5或| R4 | -CH = C-（CH2）m-R5基（其中R3是苯基 或取代的苯基; R 4是氢原子，羟基，低级烷基，低级烷氧基，低级烷酰基，低级烷酰氧基，氨基甲酰基，N-（低级烷基） - 氨基甲酰基或N，N-二（低级烷基） - 氨基甲酰基; 氢原子，吗啉代，吡咯烷基，哌啶基，六亚甲基亚氨基，低级烷基，环（低级烷基），环（低级烷基） - （低级烷基），羟基 - （低级烷基），（低级烷氧基） - （低级烷基） 取代苯基; k为0或1，m为0,1或2）; 和n为3或4，及其药学上可接受的盐，其具有优异的镇静，抗心律失常，抗感觉，抗惊厥，抗精神病，镇静，止痛或抗高血压活性。

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