POLYPEPTIDES HAVING ANTIVIRAL ACTIVITY AND METHODS FOR USE THEREOF
    2.
    发明申请
    POLYPEPTIDES HAVING ANTIVIRAL ACTIVITY AND METHODS FOR USE THEREOF 有权
    具有抗病毒活性的多肽及其使用方法

    公开(公告)号:US20130209464A1

    公开(公告)日:2013-08-15

    申请号:US13808444

    申请日:2011-07-07

    摘要: A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.

    摘要翻译: 提供了包含具有选自SEQ ID NO:4-12的氨基酸序列的肌动蛋白变体多肽的多肽。 可以将多肽作为融合蛋白的一部分提供,其包括肌动蛋白变体多肽和抗体(Fc)的片段可结晶结构域,抗体(Fab)的片段抗原结合结构域或单链可变片段 抗体(scFv)。 编码多肽的分离的核酸分子也与能够表达多肽的载体和植物细胞一起提供。 还提供了通过包膜病毒治疗受试者感染的方法,包括向受试者施用有效量的多肽。

    Polypeptides having antiviral activity and methods for use thereof
    3.
    发明授权
    Polypeptides having antiviral activity and methods for use thereof 有权
    具有抗病毒活性的多肽及其使用方法

    公开(公告)号:US08802822B2

    公开(公告)日:2014-08-12

    申请号:US13808444

    申请日:2011-07-07

    摘要: A polypeptide is provided that comprises an actinohivin variant polypeptide having an amino acid sequence selected from SEQ ID NOS: 4-12. The polypeptide can be provided as part of a fusion protein that includes the actinohivin variant polypeptide and either a fragment crystallizable domain of an antibody (Fc), a fragment antigen-binding domain of an antibody (Fab), or a single chain variable fragment of an antibody (scFv). Isolated nucleic acid molecules encoding the polypeptides are also provided along with vectors and plant cells capable of expressing the polypeptides. Methods of treating an infection of a subject by an enveloped virus are further provided and include administering an effective amount of the polypeptides to a subject.

    摘要翻译: 提供了包含具有选自SEQ ID NO:4-12的氨基酸序列的肌动蛋白变体多肽的多肽。 可以将多肽作为融合蛋白的一部分提供,其包括肌动蛋白变体多肽和抗体(Fc)的片段可结晶结构域,抗体(Fab)的片段抗原结合结构域或单链可变片段 抗体(scFv)。 编码多肽的分离的核酸分子也与能够表达多肽的载体和植物细胞一起提供。 还提供了通过包膜病毒治疗受试者感染的方法,包括向受试者施用有效量的多肽。

    PROTEIN ISOFORMS FOR DIAGNOSIS
    4.
    发明申请
    PROTEIN ISOFORMS FOR DIAGNOSIS 审中-公开
    用于诊断的蛋白质ISOFORMS

    公开(公告)号:US20110300641A1

    公开(公告)日:2011-12-08

    申请号:US12934807

    申请日:2009-03-27

    摘要: Several aspects of this invention relate to diagnosis of diabetic states in a mammal using protein isoforms. In some aspects, it relates to a method for determining the diabetic state of a mammal. This method can include, for example, (a) measuring the serum concentration of one or more protein isoforms, (b) analyzing the serum concentration of the one or more protein isoforms, and (c) determining the diabetic state of the mammal. Other aspects include kits used to perform the method. Further aspects are the isolated protein isoforms themselves, and their methods of isolation.

    摘要翻译: 本发明的几个方面涉及使用蛋白质同种型诊断哺乳动物中的糖尿病状态。 在一些方面,本发明涉及确定哺乳动物的糖尿病状态的方法。 该方法可以包括例如(a)测量一种或多种蛋白质同种型的血清浓度,(b)分析一种或多种蛋白质同种型的血清浓度,和(c)确定哺乳动物的糖尿病状态。 其他方面包括用于执行该方法的套件。 其他方面是分离的蛋白质异构体本身及其分离方法。