公开(公告)号：US20170290876A1

公开(公告)日：2017-10-12

申请号：US15315626

申请日：2015-06-24

申请人： Joy GHOSH ,  Michael ROGUSKA ,  Andrew Anh NGUYEN ,  Thomas PIETZONKA ,  Stephen Hedrick POOR ,  Matthias MACHACEK ,  Chad Eric BIGELOW

发明人： Joy GHOSH ,  Michael ROGUSKA ,  Andrew Anh NGUYEN ,  Thomas PIETZONKA ,  Stephen Hedrick POOR ,  Matthias MACHACEK ,  Chad Eric BIGELOW

IPC分类号： A61K38/00 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/02 ,  A61K45/06

CPC分类号： A61K38/005 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/02 ,  A61K45/06 ,  A61K2121/00 ,  C07K2319/31 ,  C12N15/62

摘要： The present invention is based, in part, on the discovery of peptide tags that increase the half-life and/or mean residence time of proteins or nucleic acids in the eye. In certain aspects the invention peptide tags increase the half-life and/or mean residence time of antibodies and antigen binding fragments, therapeutic proteins, protein receptors, DARPins and/or aptamers in the eye.