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1.发明授权Recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae 有权能够引起针对肺炎链球菌的免疫应答的重组细菌公开(公告)号：US09050285B2
公开(公告)日：2015-06-09
申请号：US13088141
申请日：2011-04-15
Applicant: Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
Inventor： Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
IPC: A61K39/275 , A61K39/09 , A61K39/00
CPC classification number: A61K39/092 , A61K2039/522 , A61K2039/523 , Y02A50/484
Abstract: The invention encompasses a recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae, a vaccine comprising the bacterium, and methods of using the bacterium.
Abstract translation: 本发明包括能够引起针对肺炎链球菌的免疫应答的重组细菌，包含该细菌的疫苗以及使用该细菌的方法。
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2.发明申请REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENTUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY 有权抗原和/或调节性免疫球蛋白的调控表达以增强疫苗免疫原性和/或安全性公开(公告)号：US20100124558A1
公开(公告)日：2010-05-20
申请号：US12615872
申请日：2009-11-10
Applicant: Roy Curtiss III , Shifeng Wang , Soo-Young Wanda , Wei Kong
Inventor： Roy Curtiss III , Shifeng Wang , Soo-Young Wanda , Wei Kong
CPC classification number: C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Abstract translation: 本发明涉及用于制备和使用重组细菌的组合物和方法，所述重组细菌能够调节一种或多种感兴趣的抗原的减弱和/或调控表达。
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Patent Agency Ranking
3.发明授权Regulated expression of antigen and/or regulated attentuation to enhance vaccine immunogenicity and/or safety 有权抗原的调节表达和/或调节注意力以增强疫苗免疫原性和/或安全性公开(公告)号：US08445254B2
公开(公告)日：2013-05-21
申请号：US12615872
申请日：2009-11-10
Applicant: Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
Inventor： Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
IPC: C12N1/20
CPC classification number: C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Abstract translation: 本发明涉及用于制备和使用重组细菌的组合物和方法，所述重组细菌能够调节一种或多种感兴趣的抗原的减弱和/或调控表达。
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4.发明申请公开(公告)号：US20110287052A1
公开(公告)日：2011-11-24
申请号：US13088141
申请日：2011-04-15
Applicant: Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
Inventor： Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
CPC classification number: A61K39/092 , A61K2039/522 , A61K2039/523 , Y02A50/484
Abstract: The invention encompasses a recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae, a vaccine comprising the bacterium, and methods of using the bacterium.
Abstract translation: 本发明包括能够引起针对肺炎链球菌的免疫应答的重组细菌，包含该细菌的疫苗以及使用该细菌的方法。
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公开(公告)号：US09297015B2
公开(公告)日：2016-03-29
申请号：US13789665
申请日：2013-03-07
Applicant: Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
Inventor： Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
CPC classification number: C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
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公开(公告)号：US20160199467A1
公开(公告)日：2016-07-14
申请号：US15040005
申请日：2016-02-10
Applicant: Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
Inventor： Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
CPC classification number: C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
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7.发明申请REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENTUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY 有权抗原和/或调节性免疫球蛋白的调控表达以增强疫苗免疫原性和/或安全性公开(公告)号：US20130171190A1
公开(公告)日：2013-07-04
申请号：US13789665
申请日：2013-03-07
Applicant: Roy Curtiss III , Shifeng Wang , Soo-Young Wanda , Wei Kong
Inventor： Roy Curtiss III , Shifeng Wang , Soo-Young Wanda , Wei Kong
CPC classification number: C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Abstract translation: 本发明涉及用于制备和使用重组细菌的组合物和方法，所述重组细菌能够调节一种或多种感兴趣的抗原的减弱和/或调控表达。
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