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    Pyrimidine derivatives and their pharmaceutical use
    1.
    发明授权
    Pyrimidine derivatives and their pharmaceutical use 有权
    嘧啶衍生物及其药物用途

    公开(公告)号：US08563557B2

    公开(公告)日：2013-10-22

    申请号：US13122097

    申请日：2009-10-02

    申请人： Nicholas James Westwood ,  Sonia Lain ,  Federico Medda

    发明人： Nicholas James Westwood ,  Sonia Lain ,  Federico Medda

    IPC分类号： A01N43/54 ,  C07D239/42

    CPC分类号： C07D239/54 ,  C07D239/56

    摘要： The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar′ is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano, thio, ester, acyl and amido; each R2 is independently hydrogen, halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano and thio; and R1 is as defined herein, or a physiologically acceptable salt, solvate, ester, amide or other physiologically functional derivative thereof.

    摘要翻译： 本发明提供式（I）化合物：其中：X为O或S; Y为O或S; 每个Ar和Ar'独立地是任选被一个或多个选自卤素，烷基，芳基，杂芳基，羟基，硝基，氨基，烷氧基，烷硫基，氰基，硫代， 酯，酰基和酰氨基; 每个R 2独立地是氢，卤素，烷基，芳基，杂芳基，羟基，硝基，氨基，烷氧基，烷硫基，氰基和硫代; 和R1如本文所定义，或其生理学上可接受的盐，溶剂合物，酯，酰胺或其他生理功能衍生物。

    Aroyl thiourea derivatives
    4.
    发明授权
    Aroyl thiourea derivatives 有权
    芳酰基硫脲衍生物

    公开(公告)号：US09365508B2

    公开(公告)日：2016-06-14

    申请号：US13377145

    申请日：2010-06-09

    申请人： Sonia Lain ,  Nicholas James Westwood ,  David Philip Lane

    发明人： Sonia Lain ,  Nicholas James Westwood ,  David Philip Lane

    IPC分类号： C07C335/26 ,  C07C327/54

    CPC分类号： C07C335/26 ,  C07C327/54

    摘要： The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar′ are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.

    摘要翻译： 本发明提供式（I）化合物：其中X，Y，Z 1 R 1，R 2，R 3，Ar和Ar'如本文所定义）及其生理上可接受的盐，溶剂合物，酯或酰胺，包含这些 化合物和用于医药的化合物，例如用于治疗或预防涉及细胞增殖的疾病，例如癌症，以及用于治疗或预防其它疾病。

    Compounds
    7.
    发明申请
    Compounds 有权
    化合物

    公开(公告)号：US20110245282A1

    公开(公告)日：2011-10-06

    申请号：US13122097

    申请日：2009-10-02

    申请人： Nicholas James Westwood ,  Sonia Lain ,  Federico Medda

    发明人： Nicholas James Westwood ,  Sonia Lain ,  Federico Medda

    IPC分类号： A61K31/513 ,  C07D239/56 ,  C07D239/54 ,  A61P35/00 ,  A61P3/10 ,  A61P3/04 ,  A61P9/00 ,  A61P31/18 ,  A61P33/06

    CPC分类号： C07D239/54 ,  C07D239/56

    摘要： The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar′ is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substituted with one or more substituents selected from halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano, thio, ester, acyl and amido; each R2 is independently hydrogen, halo, alkyl, aryl, heteroaryl, hydroxyl, nitro, amino, alkoxy, alkylthio, cyano and thio; and R1 is as defined herein, or a physiologically acceptable salt, solvate, ester, amide or other physiologically functional derivative thereof.

    摘要翻译： 本发明提供式（I）化合物：其中：X为O或S; Y为O或S; 每个Ar和Ar'独立地是任选被一个或多个选自卤素，烷基，芳基，杂芳基，羟基，硝基，氨基，烷氧基，烷硫基，氰基，硫代， 酯，酰基和酰氨基; 每个R 2独立地是氢，卤素，烷基，芳基，杂芳基，羟基，硝基，氨基，烷氧基，烷硫基，氰基和硫代; 和R1如本文所定义，或其生理学上可接受的盐，溶剂合物，酯，酰胺或其他生理功能衍生物。