公开(公告)号：US5780634A

公开(公告)日：1998-07-14

申请号：US549142

申请日：1995-10-27

申请人： Yoshihisa Inoue ,  Hajime Ebisu ,  Naomichi Ishida ,  Norifumi Nakamura ,  Jun Sasaki ,  Takashi Okazoe ,  Yoshitomi Morizawa ,  Arata Yasuda ,  Shuzhong Wang ,  Tomoko Ito

发明人： Yoshihisa Inoue ,  Hajime Ebisu ,  Naomichi Ishida ,  Norifumi Nakamura ,  Jun Sasaki ,  Takashi Okazoe ,  Yoshitomi Morizawa ,  Arata Yasuda ,  Shuzhong Wang ,  Tomoko Ito

IPC分类号： C07D215/12 ,  C07D215/52 ,  C07D401/06 ,  C07D401/14 ,  C07D471/04 ,  C07D215/14

CPC分类号： C07D401/06 ,  C07D215/12 ,  C07D215/52 ,  C07D401/14 ,  C07D471/04

摘要： Quinolin-2-yl benzoic acid compounds which are useful as intermediates of quinoline compounds having angiotensin II antagonist activity prepared by decarboxylating 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds in which a carboxyl group bonded to a phenyl group may be esterified, while a carboxyl group bonded to a quinoline ring is not esterified, and both rings may have one or more substituents inert to the decarboxylation reaction.

摘要翻译： 喹啉-2-基苯甲酸化合物，其可用作具有血栓素II拮抗剂活性的喹啉化合物的中间体，其通过使与羧基键合在苯基上的2-（羧基苯基）-4-喹啉羧酸化合物脱羧而被酯化，同时 与喹啉环结合的羧基不被酯化，并且两个环可以具有一个或多个对脱羧反应呈惰性的取代基。

公开(公告)号：US08546503B2

公开(公告)日：2013-10-01

申请号：US13145868

申请日：2009-01-24

申请人： Anna Zheng ,  Jian Zhang ,  Yong Guan ,  Fuzeng Hu ,  Dafu Wei ,  Shuzhong Wang

发明人： Anna Zheng ,  Jian Zhang ,  Yong Guan ,  Fuzeng Hu ,  Dafu Wei ,  Shuzhong Wang

IPC分类号： C08F2/00 ,  C08F112/08 ,  C08F4/00

CPC分类号： C08F2/38 ,  C08F297/02

摘要： This invention deals with an approach to control anionic polymerization. The anionic polymerization is conducted by adding a kind of initiator ligand compound, directly or in the form of solution into the monomer or initiator at the same or different time, or at different stages. The metal atoms in the ligand can form the association with the initiator cations, while the alkyloxy groups in the initiator ligand can restrict the entering channel of the addition of the monomers due to their relatively large volume or steric hindrance. Therefore, the initiator ligand compound can restrict the rate of anionic polymerization, restrain the side reaction, and make the anionic polymerization possible to be conducted at room or even higher temperature. The molar ratio of initiator ligand compound to initiator is from 0.01:1 to 20:1. Compared with present technologies, the method of this invention can control and adjust the homopolymerization and copolymerization rate, side reactions and the polymerization temperature, and make it possible to industrialize.

摘要翻译： 本发明涉及一种控制阴离子聚合的方法。 阴离子聚合通过在相同或不同的时间或不同阶段直接或以溶液的形式加入到单体或引发剂中进行一种引发剂配体化合物进行。 配体中的金属原子可以与引发剂阳离子形成缔合，而引发剂配体中的烷氧基可能由于其相对较大的体积或空间位阻而限制加入单体的进入通道。 因此，引发剂配体化合物可以限制阴离子聚合速度，抑制副反应，并且可以在室温甚至更高温度下进行阴离子聚合。 引发剂配体化合物与引发剂的摩尔比为0.01：1至20：1。 与现有技术相比，本发明的方法可以控制和调节均聚和共聚速率，副反应和聚合温度，并使其成为可能。

公开(公告)号：US20120116023A1

公开(公告)日：2012-05-10

申请号：US13145868

申请日：2009-01-24

申请人： Anna Zheng ,  Jian Zhang ,  Yong Guan ,  Fuzeng Hu ,  Dafu Wei ,  Shuzhong Wang

发明人： Anna Zheng ,  Jian Zhang ,  Yong Guan ,  Fuzeng Hu ,  Dafu Wei ,  Shuzhong Wang

IPC分类号： C08F2/06 ,  C08F2/02 ,  C08F12/08 ,  C08F20/14 ,  C08F299/00

CPC分类号： C08F2/38 ,  C08F297/02

摘要： This invention deals with an approach to control anionic polymerization. The anionic polymerization is conducted by adding a kind of initiator ligand compound, directly or in the form of solution into the monomer or initiator at the same or different time, or at different stages. The metal atoms in the ligand can form the association with the initiator cations, while the alkyloxy groups in the intiator ligand can restrict the entering channel of the addition of the monomers due to their relatively large volume or steric hindrance. Therfore, the initiator ligand compound can restrict the rate of anionic polymerization, restrain the side reaction, and make the anionic polymerization possible to be conducted at room or even higher temperature.The molar ratio of initiator ligand compound to initiator is from 0.01:1 to 20:1. Compared with present technologies, the method of this invention can control and adjust the homopolymerization and copolymerization rate, side reactions and the polymerization temperature, and make it possible to industrialize.

摘要翻译： 本发明涉及一种控制阴离子聚合的方法。 阴离子聚合通过在相同或不同的时间或不同阶段直接或以溶液的形式加入到单体或引发剂中进行一种引发剂配体化合物进行。 配体中的金属原子可以与引发剂阳离子形成缔合，而配体配位体中的烷氧基可能由于其相对较大的体积或空间位阻而限制加入单体的进入通道。 因此，引发剂配体化合物可以限制阴离子聚合的速率，抑制副反应，并且可以在室温甚至更高的温度下进行阴离子聚合。 引发剂配体化合物与引发剂的摩尔比为0.01：1至20：1。 与现有技术相比，本发明的方法可以控制和调节均聚和共聚速率，副反应和聚合温度，并使其成为可能。

公开(公告)号：US06903230B2

公开(公告)日：2005-06-07

申请号：US10629710

申请日：2003-07-30

申请人： Shuzhong Wang ,  Kazuhiko Hayashi ,  Shinsuke Kaga ,  Kazuya Oharu

发明人： Shuzhong Wang ,  Kazuhiko Hayashi ,  Shinsuke Kaga ,  Kazuya Oharu

IPC分类号： C07B39/00 ,  C07C17/04 ,  C07C17/18 ,  C07C67/307 ,  C07C19/08 ,  C07C25/13 ,  C07D69/76

CPC分类号： C07C17/18 ,  C07B39/00 ,  C07C17/04 ,  C07C67/307 ,  C07C69/75

摘要： It is to provide a process for synthesizing an intended fluorine-containing compound having a geminal difluoro structure with a high yield, by subjecting a carbonyl compound which is readily available to a two-stage reaction.A compound (1) such as ethyl 4-oxocyclohexanecarboxylate is reacted with a compound of the formula X-Z or a compound of the formula Z2O (wherein Z is a monovalent group which gives a leaving group of the structure —OZ, and X is a chlorine atom, a bromine atom or an iodine atom) such as phosphorus pentachloride, and then a fluorinating agent which generates fluorine anions such as HF is acted thereon to obtain a fluorine-containing compound (2) such as ethyl 4,4-difluorocyclohexanecarboxylate

摘要翻译： 通过使容易获得的羰基化合物进行两步反应来提供通过高收率合成具有偕二氟结构的目标含氟化合物的方法。 使化合物（1）如4-氧代环己烷羧酸乙酯与式XZ化合物或式Z 2 O 2化合物（其中Z是一价基团，使得 结构-OZ，X是氯原子，溴原子或碘原子）如五氯化磷，然后将产生氟等阴离子的氟化物如HF用作获得含氟化合物（2），例如 作为4,4-二氟环己烷羧酸乙酯