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公开(公告)号：US08616413B2
公开(公告)日：2013-12-31
申请号：US13395983
申请日：2011-03-02
Applicant: Shingo Koyama
Inventor： Shingo Koyama
CPC classification number: A61M5/28 , A61M5/347 , A61M5/5086 , A61M2005/3104 , A61M2005/312
Abstract: A syringe includes a syringe outer tube having a spout and a spout-mounted cap. The cap has a cap main body sealing the spout in a liquid-tight manner, a mounting section mounted onto the spout, and a breakable breaking section linking the cap main body and the mounting section to release the link upon breaking. The inner circumferential portion of the mounting section includes protrusions inserted into a groove on the outer circumferential portion of the spout which also has a tilted section tilted relative to the axis of the spout outer circumferential portion. When the cap is rotated along the axial direction of the syringe outer tube, the protrusions move along the tilted section of the groove. The mounting section is thus displaced in the base end direction and the braking section is pulled in the direction and breaks to separate the cap main body from the mounting section.
Abstract translation: 注射器包括具有喷口和喷嘴安装盖的注射器外管。 盖具有以液密方式密封喷嘴的盖主体，安装在喷口上的安装部，以及连接盖主体和安装部的断裂部，以在断裂时释放连杆。 安装部的内周部具有插入到吐出口的外周部的槽内的突起，该突起也具有相对于喷口外周部的轴线倾斜的倾斜部。 当盖沿着注射器外管的轴向旋转时，突起沿着凹槽的倾斜部分移动。 因此，安装部分在基端方向上移位，并且制动部分沿着该方向被拉动并且使盖体主体与安装部分分离。
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公开(公告)号：US08261781B2
公开(公告)日：2012-09-11
申请号：US12443216
申请日：2007-10-12
Applicant: Masaomi Imai , Hiromitsu Okabe , Shingo Koyama
Inventor： Masaomi Imai , Hiromitsu Okabe , Shingo Koyama
CPC classification number: A61M39/10 , A61M5/007 , A61M5/1408 , A61M5/1456 , A61M5/31501 , A61M5/31505 , A61M5/31511 , A61M39/223 , A61M39/24 , A61M2039/1077 , A61M2039/1083
Abstract: A medical apparatus includes: a first vessel for supplying a first liquid; a second vessel for supplying a second liquid; a mixing vessel for mixing the first and second liquids; a connector including a first flow passage connected to the first vessel, a second flow passage connected to the second vessel, a third flow passage connected to the mixing vessel and joined to the first flow passage and the second flow passage, and a discharge port which communicates with the third flow passage; and a flow passage opening/closing device provided in the third flow passage at a joint part where the first flow passage and the second flow passage join the third flow passage or at a part on a discharge port side relative to the joint part and which is operative to open/close the third flow passage.
Abstract translation: 医疗装置包括：用于供给第一液体的第一容器; 用于供应第二液体的第二容器; 用于混合第一和第二液体的混合容器; 连接器，包括连接到第一容器的第一流动通道，连接到第二容器的第二流动通道，连接到混合容器并连接到第一流动通道和第二流动通道的第三流动通道，以及排出口， 与第三流道连通; 以及流路开闭装置，其设置在第三流路的第一流路和第二流路相对于接头部的第三流路连通或排出口侧的部分的接合部， 操作以打开/关闭第三流动通道。
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公开(公告)号：US20120135484A1
公开(公告)日：2012-05-31
申请号：US13389422
申请日：2010-08-20
Applicant: Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
Inventor： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
IPC: C12P7/02
Abstract: Disclosed is a method for producing 1-(2-hydroxyethyl) 2,5,5,8a-tetramethyldecahydronaphthalene-2-ol represented by formula (2), wherein microbial conversion is carried out using a compound(s) represented by formula (1a) and/or (1b) as a substrate, the resulting culture product, in which microorganisms obtained by the microbial conversion are contained, and a solvent having an SP value within the range of 7.5 to 9.0 [(cal/cm3)1/2] are mixed together, and subsequently the aqueous phase is removed therefrom.
Abstract translation: 公开了一种由式（2）表示的1-（2-羟乙基）2,5,5,8a-四甲基十氢萘-2-醇的制备方法，其中使用式（1a）表示的化合物进行微生物转化 ）和/或（1b）作为底物，所得到的含有通过微生物转化获得的微生物的培养物和SP值在7.5〜9.0的范围内的溶剂（[cal / cm 3] 1/2 ]混合在一起，随后从中除去水相。
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公开(公告)号：US20110306104A1
公开(公告)日：2011-12-15
申请号：US13202470
申请日：2010-02-10
Applicant: Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
Inventor： Saki Hamada , Shingo Koyama , Kazuhiro Onozuka , Takaaki Watanabe
IPC: C12P7/02
CPC classification number: C12P7/22
Abstract: Provided is a process for producing a diol, which can efficiently produce a diol having a low intensity of abnormal odor and high purity. A process for producing 1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol represented by formula (2): the process containing drying a culture fluid obtained by microbial conversion using a compound(s) represented by formula (1a) and/or (1b) as a substrate, bringing the dried product of the culture fluid into contact with such a solvent that the SP value of the medium obtainable after the contact between the dried product of the culture fluid and the solvent falls in the range of 9.5 to 16 [(cal/cm3)1/2], subsequently removing the microorganism from the medium, and crystallizing the medium.
Abstract translation: 本发明提供一种二醇的制造方法，其能够有效地制造异味高，纯度低的二醇。 由式（2）表示的1-（2-羟基乙基）-2,5,5,8a-四甲基十氢萘-2-醇的制备方法：使用所表示的化合物干燥通过微生物转化获得的培养液的方法 通过式（1a）和/或（1b）作为底物，将培养液的干燥产物与这样的溶剂接触，使培养液的干燥产物与培养液接触后可获得的培养基的SP值与 溶剂在9.5至16 [（cal / cm 3）1/2]的范围内，然后从培养基中除去微生物，并使培养基结晶。
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公开(公告)号：US07405271B2
公开(公告)日：2008-07-29
申请号：US10820712
申请日：2004-04-09
Applicant: Tsuyoshi Sato , Mitsuyoshi Okuda , Shingo Koyama , Yoshifumi Izawa , Tohru Kobayashi
Inventor： Tsuyoshi Sato , Mitsuyoshi Okuda , Shingo Koyama , Yoshifumi Izawa , Tohru Kobayashi
IPC: C07K1/00
Abstract: An alkaline protease having an amino acid with one or more amino acid residues selected from among those located at (a) position 63, (b) position 89, (c) position 120, (d) positions 63 and 187, (e) position 226, (f) position 296, (g) position 304 of the amino acid sequence of SEQ ID NO: 1, or at positions corresponding to these positions, are the following amino acid residues, respectively: (a): serine, (b): histidine, (c): arginine, (d): serine,(e): tyrosine, (f): valine, and (g): serine; and a gene encoding the alkaline protease.
Abstract translation: 一种具有一个或多个氨基酸残基的氨基酸的碱性蛋白酶，其选自（a）位置63，（b）位置89，（c）位置120，（d）位置63和187，（e）位置 226，（f）位置296，（g）SEQ ID NO：1的氨基酸序列的位置304或与这些位置相应的位置分别是以下氨基酸残基：（a）：丝氨酸，（b ）：组氨酸，（c）：精氨酸，（d）：丝氨酸，（e）：酪氨酸，（f）：缬氨酸和（g）：丝氨酸; 和编码碱性蛋白酶的基因。
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Patent Agency Ranking
公开(公告)号：US20050131354A1
公开(公告)日：2005-06-16
申请号：US10500339
申请日：2002-12-26
Applicant: Kouichi Tachikawa , Shingo Koyama , Hiromitsu Okabe
Inventor： Kouichi Tachikawa , Shingo Koyama , Hiromitsu Okabe
CPC classification number: A61M5/31555 , A61M5/3156 , A61M5/31563 , A61M5/3158 , A61M2005/31508
Abstract: A syringe with which an accurate amount of a liquid can be discharged by a simple operation. The syringe 1 includes an outer tube 2, a gasket 3 slidable in the outer tube 2, a pusher 4 operable for moving the gasket 3, and a stopper 5 disposed to be slidable along the longitudinal direction of the pusher 4. The stopper 5 is fixed relative to the pusher 4 by the engagement of engaging portions, provided therein, with racks 47a, 47b formed on the pusher 4. When an operating portion 71 is depressed, the fixation condition is released, permitting regulation of the position of the stopper 5 on the pusher 4. When the depression on the operating portion 71 is canceled, the fixation condition is retained. When the pusher 4 is pressed in the tip end direction, a tip end face 66 of the stopper 5 comes into contact with a base end portion 28 of the outer tube 2, whereby the depth of insertion of the pusher 4 into the outer tube 2 is restricted, and a set amount of a chemical 100 is discharged through a diameter-reduced portion 22.
Abstract translation: 通过简单的操作能够排出精确量的液体的注射器。 注射器1包括外管2，可在外管2中滑动的垫圈3，可移动垫圈3的推动器4和沿推动器4的纵向滑动设置的止动件5.止动器5是 通过设置在其中的接合部分与形成在推动器4上的齿条47a，47b的接合部分相对于推动器4固定。当操作部分71被压下时，释放固定条件，允许调节 止动器5在推动器4上。当操作部分71上的凹陷被取消时，保持固定条件。 当推动器4在尖端方向被按压时，止动件5的前端面66与外管2的基端部28接触，由此推动器4插入到外管2中的深度 被限制，并且一定量的化学品100通过直径减小部分22排出。
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公开(公告)号：US20050026804A1
公开(公告)日：2005-02-03
申请号：US10820712
申请日：2004-04-09
Applicant: Tsuyoshi Sato , Mitsuyoshi Okuda , Shingo Koyama , Yoshifumi Izawa , Tohru Kobayashi
Inventor： Tsuyoshi Sato , Mitsuyoshi Okuda , Shingo Koyama , Yoshifumi Izawa , Tohru Kobayashi
Abstract: An alkaline protease having an amino acid, wherein one or more amino acid residues selected from among those located at (a) position 63, (b) position 89, (c) position 120, (d) positions 63 and 187, (e) position 226, (f) position 296, (g) position 304 of the amino acid sequence of SEQ NO; 1, or at positions corresponding to these positions are the following amino acid residues, respectively: (a): serine, (b): histidine, (c): arginine, (d): serine, (e): tyrosine, (f): valine, and (g): serine; and a gene encoding the alkaline protease. The alkaline protease has for example, excellent detergency against complex soil and has improved thermal stability.
Abstract translation: 具有氨基酸的碱性蛋白酶，其中选自位于（a）位置63，（b）位置89，（c）位置120，（d）位置63和187的那些中的一个或多个氨基酸残基，（e） 位置226，（f）位置296，（g）SEQ ID NO：1的氨基酸序列的位置304; （a）：丝氨酸，（b）：组氨酸，（c）：精氨酸，（d）：丝氨酸，（e）：酪氨酸，（f ）：缬氨酸和（g）：丝氨酸; 和编码碱性蛋白酶的基因。 碱性蛋白酶具有例如对复杂土壤的优异的去污力并且具有改善的热稳定性。
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公开(公告)号：US08356629B2
公开(公告)日：2013-01-22
申请号：US12665145
申请日：2008-03-26
Applicant: Shingo Koyama
Inventor： Shingo Koyama
CPC classification number: F16K11/0856 , A61M5/007 , A61M39/223 , Y10T137/86566 , Y10T137/86871
Abstract: A multiway cock has a cock body, a cock member, and a cover. The cock body has a circular tube part that has a first portion and a second portion arranged parallel to each other along the axis of the circular tube part. A first port and a second port are formed in the outer periphery of the first portion, and a third port, a fourth port, a fifth port, and a sixth port are formed in the outer periphery of the second portion. The cock member has a barrel part in which a first flow passage and a second flow passage are formed, a lever installation part, and a lever. Opening or closing of the first to sixth ports formed in the first portion and the second portion can be selected by rotating the cock member.
Abstract translation: 一个多路公鸡有一个公鸡身体，一个公鸡成员和一个封面。 旋塞体具有圆形管部，其具有沿着圆形管部的轴线彼此平行布置的第一部分和第二部分。 在第一部分的外周形成有第一端口和第二端口，在第二部分的外周形成有第三端口，第四端口，第五端口和第六端口。 旋塞构件具有形成第一流路和第二流路的筒部，杆安装部和杆。 可以通过旋转旋塞构件来选择形成在第一部分和第二部分中的第一至第六端口的打开或关闭。
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公开(公告)号：US20130006107A1
公开(公告)日：2013-01-03
申请号：US13611163
申请日：2012-09-12
Applicant: Shingo KOYAMA
Inventor： Shingo KOYAMA
IPC: A61M39/20 , A61B6/00 , A61B5/0215
CPC classification number: A61M39/223 , A61B6/481 , A61M5/007 , F16K39/06
Abstract: A liquid dispensing circuit is provided with: a multi-way cock; a first line; a second line; a third line; a fourth line; a fifth line; and a casing which houses some of the above. When a cock in the multi-way cock is situated in a priming position, a distal opening in a second part of a first flow channel communicates with a first port, and a distal opening in a third part communicates with a second port; thus, the first port and the second port are in an open state wherein the ports are connected to each other via the first flow channel, whereas a third port, a fourth port, and a sixth port are in an open state wherein the ports are connected to one another via a second flow channel.
Abstract translation: 液体分配回路具有：多路旋塞; 第一行 第二行 第三行 第四行 第五行 以及容纳上述部分的外壳。 当多通旋塞中的旋塞位于起动位置时，第一流动通道的第二部分中的远端开口与第一端口连通，第三部分中的远端开口与第二端口连通; 因此，第一端口和第二端口处于打开状态，其中端口经由第一流动通道彼此连接，而第三端口，第四端口和第六端口处于打开状态，其中端口为 通过第二流动通道彼此连接。
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公开(公告)号：US20120168464A1
公开(公告)日：2012-07-05
申请号：US13395983
申请日：2011-03-02
Applicant: Shingo Koyama
Inventor： Shingo Koyama
IPC: B67B1/00
CPC classification number: A61M5/28 , A61M5/347 , A61M5/5086 , A61M2005/3104 , A61M2005/312
Abstract: A syringe includes a syringe outer tube having a spout and a spout-mounted cap. The cap has a cap main body sealing the spout in a liquid-tight manner, a mounting section mounted onto the spout, and a breakable breaking section linking the cap main body and the mounting section to release the link upon breaking. The inner circumferential portion of the mounting section includes protrusions inserted into a groove on the outer circumferential portion of the spout which also has a tilted section tilted relative to the axis of the spout outer circumferential portion. When the cap is rotated along the axial direction of the syringe outer tube, the protrusions move along the tilted section of the groove. The mounting section is thus displaced in the base end direction and the braking section is pulled in the direction and breaks to separate the cap main body from the mounting section.
Abstract translation: 注射器包括具有喷口和喷嘴安装盖的注射器外管。 盖具有以液密方式密封喷嘴的盖主体，安装在喷口上的安装部，以及连接盖主体和安装部的断裂部，以在断裂时释放连杆。 安装部的内周部具有插入到吐出口的外周部的槽内的突起，该突起也具有相对于喷口外周部的轴线倾斜的倾斜部。 当盖沿着注射器外管的轴向旋转时，突起沿着凹槽的倾斜部分移动。 因此，安装部分在基端方向上移位，并且制动部分沿着该方向被拉动并且使盖体主体与安装部分分离。
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