公开(公告)号：US20090075946A1

公开(公告)日：2009-03-19

申请号：US11912477

申请日：2006-04-13

Applicant: Michio Ochiai ,  Kenichi Goto ,  Yoshihiro Tokudome ,  Shigenari Hirokawa

Inventor： Michio Ochiai ,  Kenichi Goto ,  Yoshihiro Tokudome ,  Shigenari Hirokawa

IPC: A61K31/661 ,  C07C61/08 ,  A61P17/00 ,  A61P29/00

CPC classification number: A61Q19/00 ,  A61K8/63 ,  A61K31/661 ,  A61Q19/02

Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.

Abstract translation: 在具有羟基的三萜酸中，至少一个羟基被磷酸化以产生磷酸化三萜酸和/或其盐，从而提高三萜酸在外用于皮肤的制剂中的溶解度，并允许 三萜酸的生理活性令人满意地发挥。 磷酸化三萜酸优选为例如熊果酸磷酸盐和/或其盐。 用于皮肤外用的制剂优选为化妆品，特别优选为准药物。

公开(公告)号：US09562912B2

公开(公告)日：2017-02-07

申请号：US14342774

申请日：2011-12-27

Applicant: Shigenari Hirokawa ,  Hiroyuki Kitajima ,  Tomomasa Shimanuki

Inventor： Shigenari Hirokawa ,  Hiroyuki Kitajima ,  Tomomasa Shimanuki

IPC: C12Q1/68 ,  G01N33/68 ,  G01N33/50 ,  C12N15/113

CPC classification number: G01N33/6872 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/20

Abstract: Provided is a method for identifying and suppressing abnormal growth of fibroblasts at an early stage. Provided is a method for identifying the growth state of fibroblasts using as an index the level of expression of ETFB (electron transfer flavoprotein beta subunit), comprising: judging, in cases where the level of expression of ETFB is high, that there is a high probability that fibroblasts are abnormally growing; and judging, in cases where the level of expression of ETFB is low, that there is a high probability that fibroblasts are normally growing. Further, by inhibition of ETFB, abnormal growth of fibroblasts can be suppressed.

Abstract translation: 提供了一种早期鉴别和抑制成纤维细胞异常生长的方法。 提供了使用作为ETFB（电子转移黄素蛋白β亚基）的表达水平的指标来鉴定成纤维细胞的生长状态的方法，其包括：在ETFB的表达水平高的情况下判断为高 成纤维细胞异常生长的可能性 并且在ETFB的表达水平低的情况下判断成纤维细胞正常生长的可能性很高。 此外，通过抑制ETFB，可以抑制成纤维细胞的异常生长。

公开(公告)号：US20140235491A1

公开(公告)日：2014-08-21

申请号：US14342774

申请日：2011-12-27

Applicant: Shigenari Hirokawa ,  Hiroyuki Kitajima ,  Tomomasa Shimanuki

Inventor： Shigenari Hirokawa ,  Hiroyuki Kitajima ,  Tomomasa Shimanuki

IPC: G01N33/68 ,  C12Q1/68 ,  C12N15/113 ,  G01N33/50

CPC classification number: G01N33/6872 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/20

Abstract: Provided is a method for identifying and suppressing abnormal growth of fibroblasts at an early stage. Provided is a method for identifying the growth state of fibroblasts using as an index the level of expression of ETFB (electron transfer flavoprotein beta subunit), comprising: judging, in cases where the level of expression of ETFB is high, that there is a high probability that fibroblasts are abnormally growing; and judging, in cases where the level of expression of ETFB is low, that there is a high probability that fibroblasts are normally growing. Further, by inhibition of ETFB, abnormal growth of fibroblasts can be suppressed.

Abstract translation: 提供了一种早期鉴别和抑制成纤维细胞异常生长的方法。 提供了使用作为ETFB（电子转移黄素蛋白β亚基）的表达水平的指标来鉴定成纤维细胞的生长状态的方法，其包括：在ETFB的表达水平高的情况下判断为高 成纤维细胞异常生长的可能性 并且在ETFB的表达水平低的情况下判断成纤维细胞正常生长的可能性很高。 此外，通过抑制ETFB，可以抑制成纤维细胞的异常生长。

公开(公告)号：US07718635B2

公开(公告)日：2010-05-18

申请号：US11912477

申请日：2006-04-13

Applicant: Michio Ochiai ,  Kenichi Goto ,  Yoshihiro Tokudome ,  Shigenari Hirokawa

Inventor： Michio Ochiai ,  Kenichi Goto ,  Yoshihiro Tokudome ,  Shigenari Hirokawa

IPC: A61K31/66 ,  C07C61/12

CPC classification number: A61Q19/00 ,  A61K8/63 ,  A61K31/661 ,  A61Q19/02

Abstract: In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.

Abstract translation: 在具有羟基的三萜酸中，至少一个羟基被磷酸化以产生磷酸化三萜酸和/或其盐，从而提高三萜酸在外用于皮肤的制剂中的溶解度，并允许 三萜酸的生理活性令人满意地发挥。 磷酸化三萜酸优选为例如熊果酸磷酸盐和/或其盐。 用于皮肤外用的制剂优选为化妆品，特别优选为准药物。