公开(公告)号：US20080009453A1

公开(公告)日：2008-01-10

申请号：US10492405

申请日：2003-08-04

Applicant: Jinhua Zhao ,  Hui Kang ,  Kesen Zhao ,  Xuliang Huang ,  Guiling Zhao ,  Jing Li ,  Hanlin Feng ,  Guanghui Yao ,  Qian Yao ,  Shengzhao Lin ,  Qi Zhou

Inventor： Jinhua Zhao ,  Hui Kang ,  Kesen Zhao ,  Xuliang Huang ,  Guiling Zhao ,  Jing Li ,  Hanlin Feng ,  Guanghui Yao ,  Qian Yao ,  Shengzhao Lin ,  Qi Zhou

IPC: A61K31/7034 ,  A61P7/00 ,  A61P9/00

CPC classification number: A61K31/7032

Abstract: The invention discloses pharmaceutical compositions containing polydatin or its pharmaceutically acceptable salts with the effect of improving microcirculation, and their application in preparing drugs which can improve microcirculation. The compositions are an non-gastrointestinal injection preparation, the preparation can be an aqueous solution which have pH 7.0-10.0 comprising 5-50% propandiol. The dosage forms of the compositions may be lyophilizing powder injection, oral form, suppository of procto-administration and other forms of administrations comprising unguent, ointment, paste film coating and the like. The compositions may be used to treat and/or prevent diseases related to microcirculation blockage. The unit form may contain 1-1000 mg polydatin or its derivatives. The invention solves the problem of using polydatin to improve microcirculation. The composition of the invention can be used in treating shock, cardiac and cerebrovascular diseases, diseases of sense organs, diabetes complication, vaculitis related to blockage of blood vessel, hemorrhoid related to circulation obstruction, skin injury and burn.

Abstract translation: 本发明公开了含有多糖或其药学上可接受的盐的药物组合物，其具有改善微循环的作用，以及它们在制备可改善微循环的药物中的应用。 组合物是非消化道注射制剂，该制剂可以是含有5-50％丙二醇的pH 7.0-10.0的水溶液。 组合物的剂型可以是冷冻干燥粉末注射剂，口服剂型，直接给药栓剂和包括无制剂，软膏剂，糊剂涂膜等的其它形式的给药。 组合物可用于治疗和/或预防与微循环阻塞有关的疾病。 单位形式可能含有1-1000 mg多聚糖或其衍生物。 本发明解决了使用多聚糖改善微循环的问题。 本发明的组合物可用于治疗休克，心脑血管疾病，感觉器官疾病，糖尿病并发症，与血管阻塞有关的空洞炎，与循环障碍相关的痔疮，皮肤损伤和烧伤。

公开(公告)号：US06414037B1

公开(公告)日：2002-07-02

申请号：US09430337

申请日：1999-10-29

Applicant: John M. Pezzuto ,  Richard C. Moon ,  Mei-Shiang Jang ,  Aomar Ouali ,  Shengzhao Lin ,  Karla Slowing Barillas

Inventor： John M. Pezzuto ,  Richard C. Moon ,  Mei-Shiang Jang ,  Aomar Ouali ,  Shengzhao Lin ,  Karla Slowing Barillas

IPC: A61K3105

CPC classification number: A61K31/7034 ,  A23L33/105 ,  A61K8/347 ,  A61K8/60 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/05 ,  A61K47/10 ,  A61K47/14 ,  A61K47/36 ,  A61K47/549 ,  A61Q19/08 ,  B82Y5/00

Abstract: A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.

Abstract translation: 提供了一种用于预防或治疗皮肤病症，疾病或疾病的方法，例如可能与炎症，阳光损伤或自然衰老相关或引起。 该方法包括给药，优选局部给药，选自白藜芦醇，其药理学上可接受的盐，酯，酰胺，前药和类似物，以及上述任何一种的组合的活性剂。 还提供了与上述方法结合使用的药物制剂。