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公开(公告)号：US09718860B2
公开(公告)日：2017-08-01
申请号：US13505705
申请日：2010-11-03
申请人： Nam-Hyuk Cho , Taek-Chin Cheong , Seung-Yong Seong , Ji Hyun Min , Jun Hua Wu , Young-Keun Kim
发明人： Nam-Hyuk Cho , Taek-Chin Cheong , Seung-Yong Seong , Ji Hyun Min , Jun Hua Wu , Young-Keun Kim
CPC分类号： C07K7/08 , A61K38/00 , A61K39/0011 , A61K2039/55555 , C07K7/06 , C07K14/001
摘要： The present invention relates to a complex of a protein comprising zinc oxide-binding peptides and zinc oxide nanoparticles, to the use thereof as a drug delivery carrier for manufacturing medicines, and to a vaccine composition and a contrast agent comprising the composite. The protein comprising zinc oxide-binding peptides significantly improves the in vivo availability of zinc oxide-binding peptides, and therefore the complex of the present invention can be used not only as a drug delivery carrier for in vivo drug delivery or intracellular drug delivery, but also for in vivo imaging or cell imaging. The complex can be used for producing separating agents for effectively separating biological materials, therapeutic agents for hyperthermia, etc., contrast agents for MRI, and beads applicable to biosensors.
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2.发明授权Use of biological surfactant as anti-inflammatory agent and tissue preservative solution 有权使用生物表面活性剂作为抗炎剂和组织防腐剂溶液公开(公告)号：US09272047B2
公开(公告)日：2016-03-01
申请号：US12619644
申请日：2009-11-16
申请人： Seung-yong Seong , Chang Gu Kang , Youn Hee Kim
发明人： Seung-yong Seong , Chang Gu Kang , Youn Hee Kim
IPC分类号： A61K31/575 , A61K47/48
CPC分类号： A61K47/48038 , A61K31/575 , A61K47/542
摘要： The present invention relates to a use of a biological surfactant as an anti-inflammatory agent and a tissue preservative solution. More particularly, the present invention is directed to an anti-inflammatory agent and a tissue preservative solution comprising a biological surfactant which blocks a reaction of a proinflammatory factor with a receptor by emulsifying the proinflammatory factor.
摘要翻译： 本发明涉及生物表面活性剂作为抗炎剂和组织防腐剂溶液的用途。 更具体地，本发明涉及一种抗炎剂和组织防腐剂溶液，其包含通过乳化促炎因子阻断促炎因子与受体的反应的生物表面活性剂。
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3.发明申请USE OF BIOLOGICAL SURFACTANT AS ANTI-INFLAMMATORY AGENT AND TISSUE PRESERVATIVE SOLUTION 有权使用生物表面活性剂作为抗炎剂和组织保存溶液公开(公告)号：US20100267684A1
公开(公告)日：2010-10-21
申请号：US12619644
申请日：2009-11-16
申请人： Seung-yong Seong , Chang Gu Kang , Youn Hee Kim
发明人： Seung-yong Seong , Chang Gu Kang , Youn Hee Kim
IPC分类号： A61K31/575 , A61P29/02 , C07J9/00 , A01N1/02 , C12N5/00
CPC分类号： A61K47/48038 , A61K31/575 , A61K47/542
摘要： The present invention relates to a use of a biological surfactant as an anti-inflammatory agent and a tissue preservative solution. More particularly, the present invention is directed to an anti-inflammatory agent and a tissue preservative solution comprising a biological surfactant which blocks a reaction of a proinflammatory factor with a receptor by emulsifying the proinflammatory factor.
摘要翻译： 本发明涉及生物表面活性剂作为抗炎剂和组织防腐剂溶液的用途。 更具体地，本发明涉及一种抗炎剂和组织防腐剂溶液，其包含通过乳化促炎因子阻断促炎因子与受体的反应的生物表面活性剂。
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4.发明申请COMPLEX OF A PROTEIN COMPRISING ZINC OXIDE-BINDING PEPTIDES AND ZINC OXIDE NANOPARTICLES, AND USE THEREOF 有权包含氧化锌结合肽和氧化锌纳米颗粒的蛋白质的复合物及其用途公开(公告)号：US20120219504A1
公开(公告)日：2012-08-30
申请号：US13505705
申请日：2010-11-03
申请人： Nam-Hyuk Cho , Taek-Chin Cheong , Seung-Yong Seong , Ji Hyun Min , Jun Hua Wu , Young-Keun Kim
发明人： Nam-Hyuk Cho , Taek-Chin Cheong , Seung-Yong Seong , Ji Hyun Min , Jun Hua Wu , Young-Keun Kim
IPC分类号： A61K38/02 , A61K47/42 , A61K39/00 , A61P35/00 , C07K16/00 , A61K38/14 , A61P37/04 , C07K14/47 , A61K49/00 , B82Y15/00 , B82Y5/00
CPC分类号： C07K7/08 , A61K38/00 , A61K39/0011 , A61K2039/55555 , C07K7/06 , C07K14/001
摘要： The present invention relates to a complex of a protein comprising zinc oxide-binding peptides and zinc oxide nanoparticles, to the use thereof as a drug delivery carrier for manufacturing medicines, and to a vaccine composition and a contrast agent comprising the composite. The protein comprising zinc oxide-binding peptides significantly improves the in vivo availability of zinc oxide-binding peptides, and therefore the complex of the present invention can be used not only as a drug delivery carrier for in vivo drug delivery or intracellular drug delivery, but also for in vivo imaging or cell imaging. The complex can be used for producing separating agents for effectively separating biological materials, therapeutic agents for hyperthermia, etc., contrast agents for MRI, and beads applicable to biosensors.
摘要翻译： 本发明涉及包含氧化锌结合肽和氧化锌纳米颗粒的蛋白质与其作为用于制备药物的药物递送载体的用途以及包含该复合物的疫苗组合物和造影剂的复合物。 包含氧化锌结合肽的蛋白质显着地改善了氧化锌结合肽的体内可利用性，因此本发明的复合物不仅可以用作用于体内药物递送或细胞内药物递送的药物递送载体，而且 也用于体内成像或细胞成像。 该复合物可用于制备用于有效分离生物材料的分离剂，用于高热疗法的治疗剂等，用于MRI的造影剂和适用于生物传感器的珠粒。
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