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16 条记录 (耗时 0.013 秒)

    1-substituted pyrrolizidine derivatives and antiarrhythmic use thereof
    3.
    发明授权
    1-substituted pyrrolizidine derivatives and antiarrhythmic use thereof 失效
    1-取代的吡咯烷啶衍生物及其抗心律不齐用途

    公开(公告)号：US4605662A

    公开(公告)日：1986-08-12

    申请号：US529548

    申请日：1983-09-06

    申请人： Seiji Miyano ,  Kunihiro Sumoto ,  Fumio Satoh ,  Hidetsura Cho

    发明人： Seiji Miyano ,  Kunihiro Sumoto ,  Fumio Satoh ,  Hidetsura Cho

    IPC分类号： A61K31/40 ,  A61P9/06 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： A novel 1-substituted pyrrolizidine derivative having the formula: ##STR1## (wherein R.sup.1 is hydrogen or a lower alkyl group; R.sup.2 is hydrogen, a lower alkyl or lower alkoxy group, or a halogen; R.sup.3 is hydrogen, a lower alkyl, lower alkoxy or amino group, or a halogen),which can be produced by reacting 1-chlorocarbonyl (or alkoxycarbonyl)pyrrolizidine with a corresponding substituted aniline (or an alkali metal salt thereof). The pyrrolizidine derivative has antiarrhythmic activity.

    摘要翻译： 具有下式的新颖的1-取代的吡咯烷子衍生物：其中R 1是氢或低级烷基; R 2是氢，低级烷基或低级烷氧基或卤素; R 3是氢，低级烷基，低级 烷氧基或氨基，或卤素），其可以通过使1-氯羰基（或烷氧基羰基）吡咯烷酮与相应的取代的苯胺（或其碱金属盐）反应来制备。 吡咯烷啶衍生物具有抗心律不齐活性。

    8-(Substituted N-phenylcarboxamidomethyl) pyrrolizidines and use thereof as antiarrhythmics
    5.
    发明授权
    8-(Substituted N-phenylcarboxamidomethyl) pyrrolizidines and use thereof as antiarrhythmics 失效
    8-（取代的N-苯基甲酰胺基甲基）吡咯烷酮及其作为抗心律失常药的用途

    公开(公告)号：US4564624A

    公开(公告)日：1986-01-14

    申请号：US473947

    申请日：1983-03-10

    申请人： Seiji Miyano ,  Kunihiro Sumoto ,  Minoru Morita ,  Fumio Sato

    发明人： Seiji Miyano ,  Kunihiro Sumoto ,  Minoru Morita ,  Fumio Sato

    IPC分类号： A61K31/40 ,  A61P9/06 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： An 8-substituted pyrrolizidine derivative representable by the formula: ##STR1## (wherein R.sup.1 stands for hydrogen or a lower alkyl group, R.sup.2 stands for hydrogen, a lower alkyl group, a lower alkoxy group or halogen, and R.sup.3 stand for a lower alkyl group, a lower alkoxy group, amino group or halogen), which can be produced by reacting a corresponding substituted anilin with 8-halocarbonylmethyl pyrrolizidine or reacting an alkali metal salt of the corresponding substituted anilin with 8-alcoxycarbonylmethyl pyrrolizidine. The derivative is useful as an antiarrhythmic agent.

    摘要翻译： 可由下式​​表示的8-取代的吡咯并吡啶衍生物：其中R1代表氢或低级烷基，R2代表氢，低级烷基，低级烷氧基或卤素，R3代表低级烷基 基团，低级烷氧基，氨基或卤素），其可以通过使相应的取代的苯胺基与8-卤代羰基甲基吡咯烷酮反应或使相应的取代的苯胺基的碱金属盐与8-烷氧羰基甲基吡咯嗪在反应中制备。 该衍生物可用作抗心律失常剂。

    3-Anilino-5,5-disubstituted-2-aminomethyl-2-cyclohexen-1-ones and the salts thereof
    9.
    发明授权
    3-Anilino-5,5-disubstituted-2-aminomethyl-2-cyclohexen-1-ones and the salts thereof 失效
    3-苯胺基-5,5-二取代-2-氨基甲基-2-环己烯-1-酮及其盐

    公开(公告)号：US3969409A

    公开(公告)日：1976-07-13

    申请号：US354139

    申请日：1973-04-24

    申请人： Seiji Miyano ,  Nobuhiro Abe

    发明人： Seiji Miyano ,  Nobuhiro Abe

    IPC分类号： C07D211/38 ,  C07D211/46 ,  C07D295/116 ,  C07D295/135 ,  C07C97/10

    CPC分类号： C07D295/116 ,  C07D211/38 ,  C07D211/46 ,  C07D295/135

    摘要： Novel cyclohexenone derivatives, which are shown by the general formula ##SPC1##Wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, lower alkyl or phenyl group; one of R.sup.3 and R.sup.4 represents a hydrogen atom or lower alkyl group, and the other represents an unsubstituted or substituted phenyl, lower alkyl or aralkyl group, or R.sup.3 and R.sup.4, taken together with the adjacent nitrogen atom, form a 5 to 6-membered heterocyclic ring; one of R.sup.5 and R.sup.6 represents a hydrogen atom or lower alkyl group, and the other represents a lower alkyl, phenyl or aralkyl group, or R.sup.5 and R.sup.6, taken together with the adjacent nitrogen atom, form an unsubstituted or substituted 5 to 6-membered heterocyclic ring, and their pharmaceutically acceptable salts, useful medicines such as analgesics.

    摘要翻译： 新的环己烯酮衍生物，其通式为R 1和R 2所示，表示氢原子，低级烷基或苯基; R3和R4中的一个表示氢原子或低级烷基，另一个表示未取代或取代的苯基，低级烷基或芳烷基，或者R3和R4与相邻氮原子一起形成5至6元 杂环 R5和R6之一表示氢原子或低级烷基，另一个表示低级烷基，苯基或芳烷基，或R5和R6与相邻氮原子一起形成未取代或取代的5至6元 杂环及其药学上可接受的盐，有用的药物，例如镇痛药。