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公开(公告)号：US20120322807A1
公开(公告)日：2012-12-20
申请号：US13526283
申请日：2012-06-18
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/496 , A61P37/08
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: Wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group
摘要翻译： 本发明提供含有由通式表示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂，其中X1表示氮原子或-CH =，R1表示-Z-R6基团， 其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子 或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示基团
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公开(公告)号：US08263599B2
公开(公告)日：2012-09-11
申请号：US12311500
申请日：2007-10-02
申请人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
发明人： Kazuo Sekiguchi , Takashi Suzuki , Yutaka Ohbuchi , Mitsuhiro Okuno , Naoto Ohi , Kenji Ohnishi , Masaaki Motoyama , Kenji Yoshida , Takeshi Kodama , Kazuhisa Sugiyama , Seiji Akamatsu , Kunihiko Kiyono , Yasuo Yanagihara , Takashi Watanabe , Kazuhiko Hayashi , Hideo Tanaka , Takumi Sumida
IPC分类号： A61K31/497
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译： 本发明的目的是提供一种STAT3 / 5激活抑制剂。 本发明提供含有通式所示的芳香族化合物或其盐作为活性成分的STAT3 / 5活化抑制剂，其中，X1表示氮原子或-CH =，R1表示-Z-R6基， 其中Z表示-CO-基团，-CH（OH） - 基等，R6表示具有1-4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基，氧原子 或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，A表示其中R 3表示 氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。
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公开(公告)号：US5925640A
公开(公告)日：1999-07-20
申请号：US853745
申请日：1997-05-09
申请人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
发明人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
IPC分类号： A61K31/495 , A61K31/496
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) and salts thereof.
摘要翻译： 本发明的目的是提供凋亡调节组合物。 根据本发明，提供了一种凋亡调节组合物，其包含至少一种通式（1）的喹诺酮衍生物及其盐作为活性成分。
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公开(公告)号：US5750529A
公开(公告)日：1998-05-12
申请号：US469505
申请日：1995-06-06
申请人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
发明人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
IPC分类号： A61K31/495 , A61K31/496 , A61K31/50
CPC分类号： A61K31/495 , A61K31/496
摘要： An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.
摘要翻译： 本发明的目的是提供凋亡调节组合物。 根据本发明，提供了一种凋亡调节组合物，其包含至少一种通式（1）的喹诺酮衍生物及其盐作为活性成分。
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公开(公告)号：US5723117A
公开(公告)日：1998-03-03
申请号：US139862
申请日：1993-10-22
申请人： Satoru Nakai , Seiji Akamatsu , Yoshihiro Masui , Tsutomu Nishida , Takashi Kamogashira , Yoshikatu Hirai
发明人： Satoru Nakai , Seiji Akamatsu , Yoshihiro Masui , Tsutomu Nishida , Takashi Kamogashira , Yoshikatu Hirai
IPC分类号： A61K38/00 , C07K14/545 , A61K38/20
CPC分类号： C07K14/545 , A61K38/00
摘要： A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and GPT activities in blood which are markers of liver diseases, and also suppresses symptoms such as choloplania.
摘要翻译： 一种预防和治疗肝病的药物，其包含选自白介素-1及其衍生物中的至少一种作为有效成分。 该药有意义地抑制作为肝脏疾病标志物的血液中的GOT和GPT活性，并抑制诸如胆红素等症状。
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公开(公告)号：US5872120A
公开(公告)日：1999-02-16
申请号：US854074
申请日：1997-05-09
申请人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
发明人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
IPC分类号： A61K31/495 , A61K31/496 , A61K31/50
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.
摘要翻译： 本发明的目的是提供凋亡调节组合物。 根据本发明，提供了一种凋亡调节组合物，其包含至少一种通式（1）的喹诺酮衍生物及其盐作为活性成分。
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公开(公告)号：US5798358A
公开(公告)日：1998-08-25
申请号：US853746
申请日：1997-05-09
申请人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
发明人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
IPC分类号： A61K31/495 , A61K31/496 , A61K31/50
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.
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公开(公告)号：US5543412A
公开(公告)日：1996-08-06
申请号：US469893
申请日：1995-06-06
申请人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
发明人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
IPC分类号： A61K31/495 , A61K31/496
CPC分类号： A61K31/495 , A61K31/496
摘要： An object of the invention is to provide hepatitis therapy. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.
摘要翻译： 本发明的目的是提供肝炎治疗。 根据本发明，提供了一种凋亡调节组合物，其包含至少一种通式（1）的喹诺酮衍生物及其盐作为活性成分。
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公开(公告)号：US20120238750A1
公开(公告)日：2012-09-20
申请号：US13409090
申请日：2012-02-29
申请人： Tae FUKUSHIMA , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
发明人： Tae FUKUSHIMA , Shuji Matsumura , Noriaki Takemura , Hideaki Satou , Nobuaki Ito , Takuya Shitsuta , Hironori Tsutsui , Michinori Tanaka , Keizo Kan , Hitoshi Nagao , Kenji Watanabe , Kuninori Tai , Takashi Nakagawa , Hideki Takasu , Makoto Sakamoto , Keisuke Miyajima , Satoshi Yamada , Yutaka Kojima , Koichi Yasumura , Naoto Ohi , Mitsuhiro Okuno , Kazuhisa Sugiyama , Kunihiko Kiyono , Takashi Suzuki , Seiji Akamatsu , Takeshi Kodama , Yasuo Yanagihara , Takumi Sumida
IPC分类号： C07D401/12 , C07D413/14 , C07D211/46 , C07D295/155 , C07D405/14
CPC分类号： C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group —CH═; R1 represents a group —Z—R6, wherein Z represents a group —CO—, a group —CH(OH)—, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group —O—, a group —CO—, a group —CH(OH)—, a lower alkylene group, or the like; and A represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译： 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或-CH =; R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，双环或三环饱和或 具有1-4个氮原子的不饱和杂环基，氧原子或硫原子; R2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。
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公开(公告)号：US5916890A
公开(公告)日：1999-06-29
申请号：US854073
申请日：1997-05-09
申请人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
发明人： Satoru Nakai , Koutoku Aihara , Hitomi Mori , Michiaki Tominaga , Masakazu Adachi , Hiroyuki Ichikawa , Seiji Akamatsu , Fumio Saito
IPC分类号： A61K31/495 , A61K31/496
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the invention is to provide an apoptosis regulating composition. According to the invention, an apoptosis regulating composition is provided which comprises, as an active ingredient, at least one carbostyril derivatives of general formula (1) ##STR1## and salts thereof.
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