公开(公告)号：US4898573A

公开(公告)日：1990-02-06

申请号：US114020

申请日：1987-10-29

申请人： Yoshinori Takenaka ,  Hirokazu Fukumi ,  Sadayoshi Sekiguchi

发明人： Yoshinori Takenaka ,  Hirokazu Fukumi ,  Sadayoshi Sekiguchi

IPC分类号： A61J1/05 ,  A61J1/10 ,  A61M1/34

CPC分类号： A61J1/10 ,  A61M1/3496

摘要： There is disclosed a blood components collector unit comprising a cannula, a blood collection bag and a membrane type blood components separator which are connected in this order through tubes, and also comprising a plasma collection reservoir and a blood cell collection reservoir, both of which are connected to the blood components separator through tubes, wherein each connection through each tube is in a fixed fashion, thereby providing a unified connection, and wherein the blood collector unit is packed in a container in a sterile state. By the use of the unit of the present invention, whole blood can be collected and separated into blood components easily at a shortened period of time without any cumbersome preparatory operations. In addition, since the unit of the present invention is compact and light in weight and can be used without any other auxiliary apparatus, the unit can be conveyed to and used in any places, such as in automobiles and outdoors. Further, the time of restraining a whole blood donor can be decreased, leading a less burdening of the donor with a great advantage.

摘要翻译： 公开了一种血液成分收集器单元，其包括套管，采血袋和膜型血液成分分离器，其通过管按此顺序连接，并且还包括血浆收集容器和血细胞收集容器，两者均为 通过管连接到血液成分分离器，其中通过每个管的每个连接是固定的，从而提供统一的连接，并且其中所述血液收集器单元被包装在处于无菌状态的容器中。 通过使用本发明的单元，可以在缩短的时间内容易地收集全血并分离成血液成分，而无需繁琐的预备操作。 此外，由于本发明的单元结构紧凑，重量轻并且可以在没有其他辅助设备的情况下使用，所以该单元可以被输送到诸如汽车和户外的任何地方使用。 此外，可以减少限制全血供体的时间，导致供体的负担更小，具有很大的优点。

公开(公告)号：US5219999A

公开(公告)日：1993-06-15

申请号：US669992

申请日：1991-03-15

申请人： Tohru Suzuki ,  Hiroyuki Ikeda ,  Kazuyo Ikeda ,  Tsugikazu Tomono ,  Sadayoshi Sekiguchi ,  Takeji Ohtani ,  Seigi Suzuki

发明人： Tohru Suzuki ,  Hiroyuki Ikeda ,  Kazuyo Ikeda ,  Tsugikazu Tomono ,  Sadayoshi Sekiguchi ,  Takeji Ohtani ,  Seigi Suzuki

IPC分类号： A61K39/395 ,  A61K38/00 ,  C07K1/34 ,  C07K14/00 ,  C07K16/00 ,  C07K16/06

CPC分类号： C07K16/00 ,  C07K16/065 ,  A61K38/00

摘要： Crude immunoglobulin G isolated from human blood plasma is treated according to a conventional technique (such as the tricalcium phosphate adsorption method) to remove aggregates therefrom to such an extent that they are not detectable by gel filtration analysis. In order to produce an aqueous solution of immunoglobulin G having a reduced anticomplementary activity, the resulting solution is then filtered through a porous polyolefin membrane having a pore size larger than the molecular size of immunoglobulin G, in the presence of a stabilizer having surface activity. The aqueous solution of immunoglobulin G so produced is suitable for use in intravenous injection because its anticomplementary activity is low.