公开(公告)号：US10472346B2

公开(公告)日：2019-11-12

申请号：US15522969

申请日：2015-10-30

申请人： The General Hospital Coporation ,  The Regents of the University of California ,  Steven L. Wagner ,  William C. Mobley ,  Rudolph E. Tanzi ,  Graham Johnson ,  Ronald Buckle ,  Nicholas Mayhew ,  Robert Jason Herr

发明人： Steven L. Wagner ,  William C. Mobley ,  Rudolph E. Tanzi ,  Graham Johnson ,  Ronald Buckle ,  Nicholas Mayhew ,  Robert Jason Herr ,  Kevin D. Rynearson

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  A61P25/28

摘要： Provided herein are compounds and methods for treating a disorder associated with aberrant A3 peptide levels, including Alzheimer's disease. Provided herein are compositions and methods for treating a disorder associated with aberrant Aβ peptide levels, including AD. Provided herein are compounds of Formula (A) or a pharmaceutically acceptable salt thereof, wherein, L′ is selected from the group consisting of C(O), C(R1)(R2), substituted or unsubstituted —C2-6 alkylene-, and substituted or unsubstituted —C3-6 cycloalkylene.