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公开(公告)号：US07511042B2
公开(公告)日：2009-03-31
申请号：US11002022
申请日：2004-12-01
申请人： Derek Cogan , Daniel R. Goldberg , Abdelhakim Hammach , Matthew Russell Netherton , Ronald A. Aungst
发明人： Derek Cogan , Daniel R. Goldberg , Abdelhakim Hammach , Matthew Russell Netherton , Ronald A. Aungst
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/12 , C07D249/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine mediated diseases. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar1，X，R3，R4，R5和R6如本文所定义。 本发明的化合物抑制细胞因子的产生，因此可用于治疗细胞因子介导的疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07285545B2
公开(公告)日：2007-10-23
申请号：US11119524
申请日：2005-04-29
申请人： Derek Cogan , Daniel R. Goldberg , Ming-Hong Hao , Zhaoming Xiong , Ronald A. Aungst , Amy L. Davis
发明人： Derek Cogan , Daniel R. Goldberg , Ming-Hong Hao , Zhaoming Xiong , Ronald A. Aungst , Amy L. Davis
IPC分类号： A61K31/397 , A61K31/444 , A61K31/4439 , A61K31/4545 , C07D401/14 , C07D401/02
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07485657B2
公开(公告)日：2009-02-03
申请号：US11120735
申请日：2005-05-03
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D233/90 , C07D231/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07078419B2
公开(公告)日：2006-07-18
申请号：US10789354
申请日：2004-02-27
申请人： Pier Francesco Cirillo , Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Matthew Russell Netherton , Kevin Chungeng Qian , Mark Stephen Ralph , Lifen Wu , Zhaoming Xiong , Ronald A. Aungst, Jr.
发明人： Pier Francesco Cirillo , Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Matthew Russell Netherton , Kevin Chungeng Qian , Mark Stephen Ralph , Lifen Wu , Zhaoming Xiong , Ronald A. Aungst, Jr.
IPC分类号： A61K31/4439 , C07D401/02
CPC分类号： C07D401/12 , C07D403/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，Y，Q，W，R 3，R 4，R SUP > 5，R 6和R y在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 该化合物也可用于治疗与肿瘤学和抗凝血剂或纤维蛋白溶解疗法有关的疾病或病症。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20150056305A1
公开(公告)日：2015-02-26
申请号：US14458898
申请日：2014-08-13
IPC分类号： C07C323/16 , A61K31/4965 , A61K33/14 , A61K31/165 , A61K31/27 , A61K31/145 , A61K45/06 , C07D241/32
CPC分类号： C07C323/16 , A61K9/0043 , A61K9/0073 , A61K9/0082 , A61K31/047 , A61K31/138 , A61K31/145 , A61K31/155 , A61K31/165 , A61K31/27 , A61K31/382 , A61K31/4965 , A61K31/7004 , A61K33/14 , A61K45/06 , C07D241/32 , C07D339/08 , Y02A50/406 , A61K2300/00
摘要： Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.
摘要翻译： 提供二硫醇粘液溶解剂。 这些药剂增加粘液或粘液过多时患者粘液液化，增加粘弹性，内聚性或粘合性。 还提供了使用这些本发明的粘液分解剂的各种治疗方法。
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公开(公告)号：US07592332B2
公开(公告)日：2009-09-22
申请号：US12201766
申请日：2008-08-29
申请人： Derek Cogan , Daniel R. Goldberg , Ming-Hong Hao , Zhaoming Xiong , Ronald A. Aungst , Amy L. Davis
发明人： Derek Cogan , Daniel R. Goldberg , Ming-Hong Hao , Zhaoming Xiong , Ronald A. Aungst , Amy L. Davis
IPC分类号： A61K31/397 , A61K31/444 , A61K31/4439 , A61K31/4545 , C07D401/14 , C07D401/02
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20090023701A1
公开(公告)日：2009-01-22
申请号：US12201766
申请日：2008-08-29
申请人： Ronald A. Aungst , Derek Cogan , Amy L. Davis , Daniel R. Goldberg , Ming-Hong Hao , Zhaoming Xiong
发明人： Ronald A. Aungst , Derek Cogan , Amy L. Davis , Daniel R. Goldberg , Ming-Hong Hao , Zhaoming Xiong
IPC分类号： A61K31/4439 , C07D401/14 , C07D401/12 , A61P35/00 , A61K31/397 , A61K31/444 , A61K31/496 , A61K31/506
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07335657B2
公开(公告)日：2008-02-26
申请号：US11426603
申请日：2006-06-27
申请人： Pier Francesco Cirillo , Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Matthew Russell Netherton , Kevin Chungeng Qian , Mark Stephen Ralph , Lifen Wu , Zhaoming Xiong , Ronald A. Aungst, Jr.
发明人： Pier Francesco Cirillo , Donghong Amy Gao , Daniel R. Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Marc Kamhi , Neil Moss , Matthew Russell Netherton , Kevin Chungeng Qian , Mark Stephen Ralph , Lifen Wu , Zhaoming Xiong , Ronald A. Aungst, Jr.
IPC分类号： A61K31/50 , A61K43/54 , C07D239/02
CPC分类号： C07D401/12 , C07D403/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，Y，Q，W，R 3，R 4，R SUP > 5，R 6和R y在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 该化合物也可用于治疗与肿瘤学和抗凝血剂或纤维蛋白溶解疗法有关的疾病或病症。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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