公开(公告)号：US4407755A

公开(公告)日：1983-10-04

申请号：US289621

申请日：1981-08-03

申请人： Robert L. Cundall ,  Derek Walker

发明人： Robert L. Cundall ,  Derek Walker

IPC分类号： C07D499/00 ,  C07D499/42 ,  C07D499/02

CPC分类号： C07D499/00

摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

摘要翻译： 将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。 这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。 取代基可以从（取代的）-2-氨基甲酰氧基草酸或（取代的）-3-氨基甲酰氧基头孢中除去，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

公开(公告)号：US4310459A

公开(公告)日：1982-01-12

申请号：US092248

申请日：1979-11-07

申请人： Robert L. Cundall ,  Derek Walker

发明人： Robert L. Cundall ,  Derek Walker

IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D501/04 ,  C07D501/02

CPC分类号： C07D499/00

摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

摘要翻译： 将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。 这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。 可以从（取代-2-氨基甲酰氧基草丁腈或（取代的）-3-氨基甲酰氧基头孢中除去取代基，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

公开(公告)号：US4374982A

公开(公告)日：1983-02-22

申请号：US290744

申请日：1981-08-03

申请人： Robert L. Cundall ,  Derek Walker

发明人： Robert L. Cundall ,  Derek Walker

IPC分类号： C07D499/00 ,  C07D501/10 ,  C07D501/18 ,  C07D501/04 ,  A61K31/545

CPC分类号： C07D499/00

摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

摘要翻译： 将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。 这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。 取代基可以从（取代的）-2-氨基甲酰氧基草酸或（取代的）-3-氨基甲酰氧基头孢中除去，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

公开(公告)号：US4518773A

公开(公告)日：1985-05-21

申请号：US507370

申请日：1983-08-19

申请人： Robert L. Cundall ,  Derek Walker

发明人： Robert L. Cundall ,  Derek Walker

IPC分类号： C07D499/00 ,  C07D501/14 ,  A61K31/545

CPC分类号： C07D499/00

摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

摘要翻译： 将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。 这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。 取代基可以从（取代的）-2-氨基甲酰氧基草酸或（取代的）-3-氨基甲酰氧基头孢中除去，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

公开(公告)号：US4426520A

公开(公告)日：1984-01-17

申请号：US307907

申请日：1981-10-02

申请人： Robert L. Cundall ,  Derek Walker

发明人： Robert L. Cundall ,  Derek Walker

IPC分类号： C07D499/00 ,  C07D501/14 ,  C07D501/20 ,  A61K31/545

CPC分类号： C07D499/00

摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcepem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

摘要翻译： 将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基甲酸酯，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢。 这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。 取代基可以从（取代的）-2-氨基甲酰氧基草酸或（取代的）-3-氨基甲酰氧基头孢中除去，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。

公开(公告)号：US4322347A

公开(公告)日：1982-03-30

申请号：US893092

申请日：1978-04-03

申请人： Robert L. Cundall ,  Derek Walker

发明人： Robert L. Cundall ,  Derek Walker

IPC分类号： A61K31/43 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D499/00 ,  C07D499/21 ,  C07D499/42 ,  C07D499/44 ,  C07D499/46 ,  C07D499/60 ,  C07D499/64 ,  C07D499/68 ,  C07D499/74 ,  C07D499/76 ,  C07D499/78 ,  C07D499/80 ,  C07D501/14 ,  C07D501/18 ,  C07D501/22 ,  C07D501/59 ,  C07D519/06 ,  C07D499/32 ,  A61K31/38

CPC分类号： C07D499/00 ,  Y02P20/55

摘要： Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

摘要翻译： 将青霉素亚砜酯与异氰酸酯反应以产生相应的（取代的）-2-氨基甲酰氧基甲基氨基钠，相应的（取代的）-3-氨基甲酰氧基头孢烯或相应的3-甲基头孢烯。 这些产物的6-或7-侧链可能被切割，得到相应的6-氨基（半阴离子）或7-氨基（cephams和cephems）化合物，后者可以被再酰化以产生不同的6-酰基-2 - 氨基甲酰氧基甲基半阴离子，7-酰基-3-氨基甲酰氧基Cephams和7-酰基-3-甲基头孢烯。 取代基可以从（取代的）-2-氨基甲酰氧基草酸或（取代的）-3-氨基甲酰氧基头孢中除去，分别得到相应的游离的2-氨基甲酰氧基甲基氨基或3-氨基甲酰氧基头孢。