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1.发明授权Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b III.sub.a 失效对GPIIbIIIa具有特异性的非肽基整合素抑制剂
公开(公告)号：US5674865A
公开(公告)日：1997-10-07
申请号：US451794
申请日：1995-05-26
Applicant: Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
Inventor： Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
IPC: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14 , A61K31/55
CPC classification number: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
Abstract translation: 提供作为非肽基血小板聚集抑制剂的苯并二氮二酮衍生物。 该抑制剂有效地抑制纤维蛋白原与GPIIbIIIa受体的结合，并且提供在用于治疗阻断血小板聚集的疾病的治疗组合物中。 这些非肽基抑制剂与溶血栓剂和抗凝剂组合提供。
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Patent Agency Ranking2.发明授权Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b III.sub.a receptor 失效对GPIIbIIIa受体具有特异性的非肽基整联蛋白抑制剂
公开(公告)号：US5565449A
公开(公告)日：1996-10-15
申请号：US452479
申请日：1995-05-26
Applicant: Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
Inventor： Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
IPC: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14 , A61K31/55
CPC classification number: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
Abstract translation: 提供作为非肽基血小板聚集抑制剂的苯并二氮二酮衍生物。 该抑制剂有效地抑制纤维蛋白原与GPIIbIIIa受体的结合，并且提供在用于治疗阻断血小板聚集的疾病的治疗组合物中。 这些非肽基抑制剂与溶血栓剂和抗凝剂组合提供。
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3.发明授权Nonpeptidyl platelet aggregation inhibitors having specificity for the GPII.sub.b III.sub. receptor 失效对GPIIbIII受体具有特异性的非肽基血小板聚集抑制剂
公开(公告)号：US5250679A
公开(公告)日：1993-10-05
申请号：US866931
申请日：1992-04-10
Applicant: Brent Blackburn , Robert McDowell , Thomas Gadek , Peter Barker , Lawrence McGee , Rob Webb
Inventor： Brent Blackburn , Robert McDowell , Thomas Gadek , Peter Barker , Lawrence McGee , Rob Webb
IPC: A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/5517 , A61K31/553 , A61P7/02 , A61P43/00 , C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14 , C07D401/06 , C07D401/12 , C07D261/14
CPC classification number: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
Abstract translation: 提供作为非肽基血小板聚集抑制剂的苯并二氮二酮衍生物。 该抑制剂有效地抑制纤维蛋白原与GPIIbIIIa受体的结合，并且提供在用于治疗阻断血小板聚集的疾病的治疗组合物中。 这些非肽基抑制剂与溶血栓剂和抗凝剂组合提供。
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4.发明授权Nonpeptidyl integrin inhibitors having specificity for the GPII.sub.b III.sub.a receptor 失效对GPIIbIIIa受体具有特异性的非肽基整联蛋白抑制剂
公开(公告)号：US5674863A
公开(公告)日：1997-10-07
申请号：US451849
申请日：1995-05-26
Applicant: Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
Inventor： Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
IPC: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14 , C07D285/36 , A61K31/55 , C07D513/04
CPC classification number: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
Abstract translation: 提供作为非肽基血小板聚集抑制剂的苯并二氮二酮衍生物。 该抑制剂有效地抑制纤维蛋白原与GPIIbIIIa受体的结合，并且提供在用于治疗阻断血小板聚集的疾病的治疗组合物中。 这些非肽基抑制剂与溶血栓剂和抗凝剂组合提供。
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公开(公告)号：US5663166A
公开(公告)日：1997-09-02
申请号：US452056
申请日：1995-05-26
Applicant: Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
Inventor： Brent Blackburn , Peter Barker , Thomas Gadek , Robert McDowell , Lawrence McGee , Todd Somers , Rob Webb , Kirk Robarge
IPC: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14 , A61K31/55 , C07D487/04
CPC classification number: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
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6.发明授权Benzazepine platelet aggregation inhibitors having specificity for the GPII.sub.b III.sub.a receptor 失效对于GPIIbIIIa受体具有特异性的苯扎西平血小板聚集抑制剂
公开(公告)号：US5403836A
公开(公告)日：1995-04-04
申请号：US58722
申请日：1993-05-06
Applicant: Brent Blackburn , Robert McDowell , Thomas Gadek , Rob Webb
Inventor： Brent Blackburn , Robert McDowell , Thomas Gadek , Rob Webb
IPC: A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/5517 , A61K31/553 , A61P7/02 , A61P43/00 , C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14 , C07D401/06 , C07D401/12
CPC classification number: C07D223/16 , C07D243/10 , C07D243/14 , C07D267/14
Abstract: A benzazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
Abstract translation: 提供作为非肽基血小板聚集抑制剂的苯并氮杂衍生物。 该抑制剂有效地抑制纤维蛋白原与GPIIbIIIa受体的结合，并且提供在用于治疗阻断血小板聚集的疾病的治疗组合物中。 这些非肽基抑制剂与溶血栓剂和抗凝剂组合提供。
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