公开(公告)号：US5152995A

公开(公告)日：1992-10-06

申请号：US420969

申请日：1989-10-12

Applicant: Richard A. Runkel ,  Stephen A. Berry ,  Mahmood M. Ghani

Inventor： Richard A. Runkel ,  Stephen A. Berry ,  Mahmood M. Ghani

IPC: A23K1/00 ,  A23K1/17

CPC classification number: A23K20/195 ,  A23K40/30

Abstract: Acid-sensitive antibiotic esters for oral administration to livestock are stabilized by incorporation in premix formulations comprising a carrier, a base, a protective coating, and optionally a sealant film.

Abstract translation: 用于口服给牲畜的酸敏感抗生素酯通过掺入包含载体，碱，保护性涂层和任选的密封剂膜的预混合制剂来稳定。

公开(公告)号：US5035891A

公开(公告)日：1991-07-30

申请号：US398106

申请日：1989-08-24

Applicant: Richard A. Runkel ,  Jung-Chung Lee

Inventor： Richard A. Runkel ,  Jung-Chung Lee

IPC: A61K9/00 ,  A61K9/16 ,  A61K31/565

CPC classification number: A61K9/0092 ,  A61K31/565 ,  A61K9/0004 ,  A61K9/0024 ,  A61K9/1617 ,  A61K9/1641

Abstract: A sustained release, reservoir-type subcutaneous implant device for the sustained administration to a subject of a biologically active compound comprises:an effective amount of a biologically active compound;an amount of a solid hydrophilic polymer sufficient to cause swelling of the device by osmotic pressure after implantation;an effective amount of a solubilizing agent; anda sufficient amount of a non-porous rate-controlling membrane which completely encapsulates said biologically active compound, wherein said rate-controlling membrane is permeable to said biologically active compound, but is impermeable to said solubilizing agent. This device is particularly advantageous for the administration of growth promoting compounds to livestock.

Abstract translation: 用于持续施用生物活性化合物受试者的持续释放的储库型皮下植入装置包括：有效量的生物活性化合物; 一定量的固体亲水性聚合物，足以在植入后通过渗透压使器件膨胀; 有效量的增溶剂; 以及足量的完全封装所述生物活性化合物的无孔速率控制膜，其中所述速率控制膜对所述生物活性化合物是可渗透的，但对所述增溶剂是不可渗透的。 该装置对于向家畜施用生长促进化合物是特别有利的。