公开(公告)号：US09062070B2

公开(公告)日：2015-06-23

申请号：US14239649

申请日：2012-08-16

Applicant: Alexander Pasternak ,  Timothy Blizzard ,  Harry Chobanian ,  Reynalda de Jesus ,  Fa-Xiang Ding ,  Shuzhi Dong ,  Candido Gude ,  Dooseop Kim ,  Haifeng Tang ,  Shawn Walsh ,  Barbara Pio ,  Jinlong Jiang

Inventor： Alexander Pasternak ,  Timothy Blizzard ,  Harry Chobanian ,  Reynalda de Jesus ,  Fa-Xiang Ding ,  Shuzhi Dong ,  Candido Gude ,  Dooseop Kim ,  Haifeng Tang ,  Shawn Walsh ,  Barbara Pio ,  Jinlong Jiang

IPC: C07D498/04 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K45/06 ,  C07D487/04 ,  C07D513/04

CPC classification number: C07D498/04 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K45/06 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

Abstract translation: 本发明提供式Ia化合物及其药学上可接受的盐，它们是ROMK（Kir1.1）通道的抑制剂。 该化合物可以用作利尿剂和/或利尿钠剂，并且用于治疗和预防包括心血管疾病如高血压，心力衰竭以及与过量盐和水滞留有关的病症的医学病症。

公开(公告)号：US20140206618A1

公开(公告)日：2014-07-24

申请号：US14239649

申请日：2012-08-16

Applicant: Alexander Pasternak ,  Timothy Blizzard ,  Harry Chobanian ,  Reynalda de Jesus ,  Fa-Xiang Ding ,  Shuzhi Dong ,  Candido Gude ,  Dooseop Kim ,  Haifeng Tang ,  Shawn Walsh ,  Barbara Pio ,  Jinlong Jiang

Inventor： Alexander Pasternak ,  Timothy Blizzard ,  Harry Chobanian ,  Reynalda de Jesus ,  Fa-Xiang Ding ,  Shuzhi Dong ,  Candido Gude ,  Dooseop Kim ,  Haifeng Tang ,  Shawn Walsh ,  Barbara Pio ,  Jinlong Jiang

IPC: C07D498/04 ,  A61K45/06 ,  A61K31/4985 ,  C07D513/04 ,  A61K31/542 ,  C07D487/04 ,  A61K31/5383 ,  A61K31/553

CPC classification number: C07D498/04 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K45/06 ,  C07D487/04 ,  C07D513/04

Abstract: The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.

Abstract translation: 本发明提供式Ia化合物及其药学上可接受的盐，它们是ROMK（Kir1.1）通道的抑制剂。 这些化合物可以用作利尿剂和/或利尿钠剂，并且用于治疗和预防包括心血管疾病如高血压，心力衰竭以及与过量盐和保水有关的病症的医学病症。