公开(公告)号：US20090171089A1

公开(公告)日：2009-07-02

申请号：US12399292

申请日：2009-03-06

Applicant: Charles L. CYWIN ,  Scott E. JAKES ,  Joachim HEIDER ,  Mark A. BOBKO ,  Renee L. DES JARLAIS ,  Mark PLAYER ,  James RINKER ,  Michael WINTERS ,  Bao-ping ZHAO

Inventor： Charles L. CYWIN ,  Scott E. JAKES ,  Joachim HEIDER ,  Mark A. BOBKO ,  Renee L. DES JARLAIS ,  Mark PLAYER ,  James RINKER ,  Michael WINTERS ,  Bao-ping ZHAO

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US07705151B2

公开(公告)日：2010-04-27

申请号：US12399292

申请日：2009-03-06

Applicant: Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

Inventor： Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

IPC: C07D471/02 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US07678911B2

公开(公告)日：2010-03-16

申请号：US12014190

申请日：2008-01-15

Applicant: Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

Inventor： Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

IPC: C07D471/02 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US07321041B2

公开(公告)日：2008-01-22

申请号：US10413980

申请日：2003-04-15

Applicant: Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

Inventor： Charles L. Cywin ,  Scott E. Jakes ,  Joachim Heider ,  Mark A. Bobko ,  Renee L. Des Jarlais ,  Mark Player ,  James Rinker ,  Michael Winters ,  Bao-ping Zhao

IPC: C07D471/02

CPC classification number: C07D471/04

Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

Abstract translation: 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8是 其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。