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1.发明申请GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY 有权通过位置21中的芳香链接蛋白连接到硝酸盐的葡萄糖结合蛋白及其在眼科学中的应用公开(公告)号：US20110144073A1
公开(公告)日：2011-06-16
申请号：US13056921
申请日：2009-07-07
申请人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
发明人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
CPC分类号： C07J71/0031 , C07J41/005
摘要： The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
摘要翻译： 本发明涉及氟轻松，丙酸钠，倍他米松和倍氯米松的硝基氧基衍生物，其制备方法，含有这些化合物的药物组合物，以及使用这些化合物和组合物治疗糖尿病性黄斑水肿，糖尿病性视网膜病变，黄斑变性， 黄斑变性等视网膜黄斑病变。
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公开(公告)号：US08518920B2
公开(公告)日：2013-08-27
申请号：US13056921
申请日：2009-07-07
申请人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
发明人： Francesca Benedini , Annalisa Bonfanti , Valerio Chiroli , Rebecca Steele , Ennio Ongini , Stefano Biondi
IPC分类号： A61K31/58 , A61K31/573 , C07J5/00 , C07J71/00
CPC分类号： C07J71/0031 , C07J41/005
摘要： The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
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3.发明申请NEW NO-RELEASING STEROIDS FOR THE TREATMENT OF RETINA AND MACULA LUTEA DISEASES 审中-公开用于治疗复发性麻疹和麻疯病的新型无释放甾体公开(公告)号：US20110130375A1
公开(公告)日：2011-06-02
申请号：US13056946
申请日：2009-07-24
IPC分类号： A61K31/573 , A61P29/00 , A61P27/02 , C07J5/00
CPC分类号： C07J41/0038 , A61K9/0048
摘要： The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof The compounds are useful for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.
摘要翻译： 本发明涉及通式（I）的化合物及其药学上可接受的盐或立体异构体。该化合物可用于治疗糖尿病性黄斑水肿，糖尿病性视网膜病变，黄斑变性，年龄相关性黄斑变性和其他视网膜和黄斑黄斑病。
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