公开(公告)号：US08192755B2

公开(公告)日：2012-06-05

申请号：US10495961

申请日：2001-11-19

申请人： Himadri Sen ,  Rajesh Suresh Kshirsagar ,  Shailesh Suresh Bhamare

发明人： Himadri Sen ,  Rajesh Suresh Kshirsagar ,  Shailesh Suresh Bhamare

IPC分类号： A61K9/22

CPC分类号： A61K31/545 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/209 ,  A61K31/24 ,  A61K33/06 ,  Y10S514/964 ,  A61K2300/00

摘要： An improved stable pharmaceutical composition for controlled release of an active ingredient comprises a betalactam antibiotic such as cephalexin, cefaclor or their pharmaceutically acceptable hydrates, salts or esters as active ingredient, a calcium salt and a mixture of hydrophilic polymers selected from the group consisting of at least one sodium alginate and one xanthan gum and with or without hydroxypropyl methylcellulose, said composition optionally containing probenecid. The composition may also contain one or more of a water soluble and/or water dispersible diluent, wherein the quantities of the hydrophilic polymers and water soluble and/or water dispersible diluents are such that the therapeutically effective active ingredient is released at a rate suitable for once or twice daily administration of the pharmaceutical composition.

摘要翻译： 用于控制释放活性成分的改进的稳定药物组合物包括β-内酰胺抗生素如头孢氨苄，头孢克洛或其药学上可接受的水合物，作为活性成分的盐或酯，钙盐和亲水性聚合物的混合物，所述亲水性聚合物选自 至少一种藻酸钠和一种黄原胶，以及含或不含羟丙基甲基纤维素，所述组合物任选地含有丙磺舒。 组合物还可以含有一种或多种水溶性和/或水分散性稀释剂，其中亲水性聚合物和水溶性和/或水分散性稀释剂的量使得治疗有效的活性成分以适合于 每天一次或两次给药药物组合物。

公开(公告)号：US06932981B2

公开(公告)日：2005-08-23

申请号：US09928466

申请日：2001-08-13

申请人： Himadri Sen ,  Rajesh Suresh Kshirsagar ,  Anupa Ramesh Menjoge

发明人： Himadri Sen ,  Rajesh Suresh Kshirsagar ,  Anupa Ramesh Menjoge

IPC分类号： A61K9/20 ,  A61K9/50

CPC分类号： A61K9/5026 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/5073

摘要： A fast disintegrating controlled release oral composition comprising a core material containing cefuroxime axetil present as controlled release form, the cefuroxime axetil being provided with an outer coating of a copolymer selected from aqueous dispersions of enteric methacrylic acid and methacrylic acid esters anionic copolymers having carboxyl group as the functional group or mixtures thereof and an inner coating of a sustained-release copolymer selected from aqueous dispersions of acrylate and methacrylate pH independent copolymers having quaternary ammonium group as a functional group or mixtures thereof, and optionally probenecid. Additionally, the coating composition may contain plasticizers. The composition is suitable for once daily administration.

摘要翻译： 一种快速崩解的控释口服组合物，其包含含有作为控制释放形式存在的头孢呋辛酯的核心材料，头孢呋辛酯具有选自肠型甲基丙烯酸的水分散体和甲基丙烯酸酯的共聚物的外涂层，所述共聚物具有羧基作为阴离子共聚物 官能团或其混合物，以及选自丙烯酸酯和甲基丙烯酸酯的水分散体的具有季铵基团作为官能团的水分散体或其混合物的缓释共聚物的内涂层，以及任选的丙磺舒。 另外，涂料组合物可以含有增塑剂。 该组合物适合于每日一次给药。