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    "> THERAPY OPTION FOR RECOLORATION OF HAIR VIA BISPHOSPHONATES BY PHYSIOLOGICAL REPIGMENTATION WITH AGE-RELATED AND/OR PREMATURE
    9.
    发明申请
    THERAPY OPTION FOR RECOLORATION OF HAIR VIA BISPHOSPHONATES BY PHYSIOLOGICAL REPIGMENTATION WITH AGE-RELATED AND/OR PREMATURE "GRAYED" PATIENTS 审中-公开

    公开(公告)号：US20110105435A1

    公开(公告)日：2011-05-05

    申请号：US12734464

    申请日：2008-11-04

    申请人： Holger Köhler ,  Rainer Pooth

    发明人： Holger Köhler ,  Rainer Pooth

    IPC分类号： A61K31/675 ,  A61K31/663 ,  A61P43/00

    CPC分类号： A61K31/663 ,  A61K8/55 ,  A61Q5/10

    摘要： The present invention relates to the use of a bisphosphonate derivative according to general Formula I and/or a pharmaceutically acceptable salt thereof, wherein R1 and/or R2 are independently selected out of a group comprising hydrogen, hydroxyl, halogen, pseudohalogen, formyl, carboxy- and/or carbonyl derivatives, alkyl, long-chain alkyl, alkoxy, long-chain alkoxy, cycloalkyl, halogenalkyl, aryl, arylene, halogenaryl, heteroaryl, heteroarylene, heterocycloalkylene, heterocycloalkyl, halogenheteroaryl, alkenyl, halogenalkenyl, alkinyl, halogenalkinyl, keto, ketoaryl, halogenketoaryl, ketoheteroaryl, ketoalkyl, halogenketoalkyl, ketoalkenyl, halogenketoalkenyl, phosphoalkyl, phosphonate, phosphate, phosphine, phosphine oxide, phosphoryl, phosphoaryl, suiphonyl, sulphoalkyl, sulphoarenyl, sulphonate, sulphate, sulphone, amine, polyether, silylalkyl, silylalkyloxy, and wherein at appropriate residues one or more non-adjacent CH2-groups may be replaced independently from each other with —O—, —S—, —NH—, —NRo—, —SiRoRoo—, —CO—, —COO—, —OCO—, —OCO—O—, —SO2—, —S—CO—, —CO—S—, —CY1═CY2 or —C≡C— in that way that O and/or S-atoms are not connected directly with each other, likewise replaced optionally with aryl- or heteroaryl which preferably contain 1 to 30 C-atoms (terminal CH3-groups are meant as CH2-groups in terms of CH2—H), wherein Ro, Roo, Y1 and Y2 are independently selected out of a group comprising alkyl and aryl, in the manufacture of a pharmaceutical for the treatment of age-related and/or premature graying of hair.