公开(公告)号：US07511146B2

公开(公告)日：2009-03-31

申请号：US10926557

申请日：2004-08-26

申请人： Duane A. Burnett ,  Wen-Lian Wu ,  Thavalakulamgara K. Sasikumar ,  William J. Greenlee ,  Mary Ann Caplen ,  Tao Guo ,  Rachael Catherine Hunter

发明人： Duane A. Burnett ,  Wen-Lian Wu ,  Thavalakulamgara K. Sasikumar ,  William J. Greenlee ,  Mary Ann Caplen ,  Tao Guo ,  Rachael Catherine Hunter

IPC分类号： C07D211/32

CPC分类号： C04B35/632 ,  C07D401/06 ,  C07D401/12

摘要： The present invention discloses compounds of formula I wherein Ar, Y, m, n, R1 and R4 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

摘要翻译： 本发明公开了其中Ar，Y，m，n，R 1和R 4在本文中定义的式I化合物，所述化合物是用于黑色素浓缩激素（MCH）的新型拮抗剂，以及制备这些化合物的方法。 在另一个实施方案中，本发明公开了包含这样的MCH拮抗剂的药物组合物以及使用它们治疗肥胖，代谢紊乱，进食障碍如食欲过盛和糖尿病的方法。