公开(公告)号：US20200181121A1

公开(公告)日：2020-06-11

申请号：US16791916

申请日：2020-02-14

Applicant: Xuefeng Mei ,  Jianrong Wang ,  Qihui Yu

Inventor： Xuefeng Mei ,  Jianrong Wang ,  Qihui Yu

IPC: C07D403/10 ,  C07D285/20

Abstract: The present disclosure relates to a cocrystal of telmisartan and hydrochlorothiazide, a preparation method and use thereof. In the cocrystal, the molar ratio of telmisartan and hydrochlorothiazide is 1:1. The cocrystal of telmisartan and hydrochlorothiazide was characterized by X-ray powder diffraction (XRPD), proton nuclear magnetic resonance spectra (1H-NMR), thermal gravimetric analysis (TG), scanning differential calorimetry (DSC) and infrared (IR) spectra, and it was found that the maximum plasma concentration of the cocrystal in SD rats was higher than that of any one of hydrochlorothiazide and telmisartan itself. The cocrystal of telmisartan and hydrochlorothiazide has a simple preparation method and good physical and chemical properties.