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公开(公告)号：US08530631B2
公开(公告)日：2013-09-10
申请号：US12731000
申请日：2010-03-24
Applicant: Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
Abstract: The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.
Abstract translation: 本发明提供两亲化合物和操作膜蛋白的方法。 本发明的化合物，例如式I-XIX的化合物可以由容易获得的原料制备。 与许多已知的洗涤剂相比，两亲化合物可以以相对低的浓度操纵膜蛋白。 该化合物可用于帮助分离膜蛋白，例如帮助其溶解和/或纯化。 该化合物也可用于帮助膜蛋白的功能和结构测定，包括其稳定和结晶。
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Patent Agency Ranking
公开(公告)号：US08263754B2
公开(公告)日：2012-09-11
申请号：US12420701
申请日：2009-04-08
Applicant: Samuel Helmer Gellman , Pil Seok Chae , Philip D. Laible , Marc J. Wander
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Philip D. Laible , Marc J. Wander
IPC: C07H15/00 , A61K31/7028
CPC classification number: C07H15/02
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Abstract translation: 本发明提供用于操作膜蛋白的两亲物。 两亲物可以在亲水部分和/或亲脂部分中具有来源于碳水化合物的亲水基团和分支点。 这样的两亲物可用作溶解和稳定膜蛋白质的洗涤剂，包括从细菌膜获得的光合蛋白超级组件。
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公开(公告)号：US20100311956A1
公开(公告)日：2010-12-09
申请号：US12731000
申请日：2010-03-24
Applicant: Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Brian Kobilka , Soren Rasmussen
Abstract: The invention provides amphiphilic compounds and methods for manipulating membrane proteins. Compounds of the invention, for example, the compounds of Formulas I-XIX, can be prepared from readily available starting materials. The amphiphilic compounds can manipulate membrane protein at relatively low concentrations compared to many known detergents. The compounds can be used to aid the isolation of membrane proteins, for example, to aid their solubilization and/or purification. The compounds can also be used to aid the functional and structural determination of membrane proteins, including their stabilization and crystallization.
Abstract translation: 本发明提供两亲化合物和操作膜蛋白的方法。 本发明的化合物，例如式I-XIX的化合物可以由容易获得的原料制备。 与许多已知的洗涤剂相比，两亲化合物可以以相对低的浓度操纵膜蛋白。 该化合物可用于帮助分离膜蛋白，例如帮助其溶解和/或纯化。 该化合物也可用于帮助膜蛋白的功能和结构测定，包括其稳定和结晶。
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公开(公告)号：US08877906B2
公开(公告)日：2014-11-04
申请号：US13608385
申请日：2012-09-10
Applicant: Samuel Helmer Gellman , Pil Seok Chae , Phillip D. Laible , Marc J. Wander
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Phillip D. Laible , Marc J. Wander
IPC: C07H15/00 , C07H15/02 , C07H15/18 , A61K31/7028
CPC classification number: C07H15/02
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Abstract translation: 本发明提供用于操作膜蛋白的两亲物。 两亲物可以在亲水部分和/或亲脂部分中具有来源于碳水化合物的亲水基团和分支点。 这样的两亲物可用作溶解和稳定膜蛋白质的洗涤剂，包括从细菌膜获得的光合蛋白超级组件。
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公开(公告)号：US20130001465A1
公开(公告)日：2013-01-03
申请号：US13608385
申请日：2012-09-10
Applicant: Samuel Helmer GELLMAN , Pil Seok CHAE , Phillip D. LAIBLE , Marc J. WANDER
Inventor： Samuel Helmer GELLMAN , Pil Seok CHAE , Phillip D. LAIBLE , Marc J. WANDER
IPC: C07H15/18 , C07K1/00 , C09K3/00 , C07C239/16
CPC classification number: C07H15/02
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
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公开(公告)号：US20090270598A1
公开(公告)日：2009-10-29
申请号：US12420701
申请日：2009-04-08
Applicant: Samuel Helmer Gellman , Pil Seok Chae , Philip D. Laible , Marc J. Wander
Inventor： Samuel Helmer Gellman , Pil Seok Chae , Philip D. Laible , Marc J. Wander
CPC classification number: C07H15/02
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Abstract translation: 本发明提供用于操作膜蛋白的两亲物。 两亲物可以在亲水部分和/或亲脂部分中具有来源于碳水化合物的亲水基团和分支点。 这样的两亲物可用作溶解和稳定膜蛋白质的洗涤剂，包括从细菌膜获得的光合蛋白超级组件。
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