公开(公告)号：US08664411B2

公开(公告)日：2014-03-04

申请号：US12665580

申请日：2008-07-01

Applicant: Wen-Lian Wu ,  Thomas A. Bara ,  Duane A. Burnett ,  John W. Clader ,  Martin S. Domalski ,  Yan Jin ,  Hubert B. Josien ,  Hongmei Li ,  Xian Liang ,  Dmitri A. Pissarnitski ,  Thavalakulamgara K. Sasikumar ,  Jesse K. Wong ,  Ruo Xu ,  Zhiqiang Zhao ,  Paul McNamara

Inventor： Wen-Lian Wu ,  Thomas A. Bara ,  Duane A. Burnett ,  John W. Clader ,  Martin S. Domalski ,  Yan Jin ,  Hubert B. Josien ,  Hongmei Li ,  Xian Liang ,  Dmitri A. Pissarnitski ,  Thavalakulamgara K. Sasikumar ,  Jesse K. Wong ,  Ruo Xu ,  Zhiqiang Zhao ,  Paul McNamara

IPC: C07D311/80 ,  C07D493/04 ,  A61K31/352

CPC classification number: C07D493/04 ,  C07D311/78 ,  C07D407/12

Abstract: Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)—O—C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)—O—C(O)-heteroaryl and a basic tertiary amine.

Abstract translation: 公开了下式的新型γ-分泌酶抑制剂。 还公开了抑制γ-分泌酶，治疗神经变性疾病的方法和治疗阿尔茨海默氏病的方法。 还公开了在一个反应​​步骤中使用醛（或酮）和被两个吸电子基团取代的烷基的混合物制备烯烃的方法，并使该混合物与：（a）磺酰卤（例如磺酰氯） 和（b）磺酰基酐和碱性胺，或（c）芳基-C（O） - 卤化物和碱式叔胺，或（d）芳基-C（O） - OC（O） - 芳基和碱式叔胺，或（e）杂芳基-C（O） - 卤化物和碱式叔胺，或（f）杂芳基-C（O）-OC（O） - 杂芳基和 碱性叔胺。

公开(公告)号：US20130090524A1

公开(公告)日：2013-04-11

申请号：US13200973

申请日：2011-10-06

Applicant: Paul McNamara

Inventor： Paul McNamara

IPC: A61F5/00

CPC classification number: A61H19/44 ,  A61H2201/0103 ,  A61H2201/1685

Abstract: An inflatable form comprising a distal portion that is generally elongate and cylindrical in shape and a proximal portion that is generally bulbous, providing a grasping and manipulation means. The inflatable form is engaged with a comfortable surface, also known as a comfort-sleeve that is fitted over the elongate portion that is intended to be inserted into the body cavity. Inflatable forms provide a compact, discrete item that may be reused or may be disposed of after use.

Abstract translation: 一种可膨胀形式，其包括通常为细长且圆柱形的远端部分和通常为球形的近端部分，提供抓握和操纵装置。 可膨胀的形式与舒适的表面接合，该舒适的表面也称为舒适套筒，该舒适的套筒装配在预期被插入体腔的细长部分上。 充气式表格提供了可以重复使用或可能在使用后丢弃的紧凑型离散物品。

公开(公告)号：US08054954B1

公开(公告)日：2011-11-08

申请号：US11765782

申请日：2007-06-20

Applicant: Cherian Abraham ,  Simon Boland ,  Karen El-Azzi ,  Paul McNamara ,  Ted Saoumi

Inventor： Cherian Abraham ,  Simon Boland ,  Karen El-Azzi ,  Paul McNamara ,  Ted Saoumi

IPC: H04M1/64

CPC classification number: H04M1/7255 ,  H04M1/2478 ,  H04M1/2535 ,  H04M1/656 ,  H04M3/42221 ,  H04M3/56 ,  H04M2203/30 ,  H04M2250/62

Abstract: The present invention provides a method, device, and system for taking voice memos during a communication session. More specifically, voice memos may be taken using the same communication device that is used in the communication session. This can be accomplished by automatically muting the communication device and establishing a communication channel with another endpoint, such as a recording endpoint, to record audio signals transmitted by the communication device.

Abstract translation: 本发明提供了一种用于在通信会话期间取得语音留言的方法，装置和系统。 更具体地，可以使用在通信会话中使用的相同通信设备来进行语音留言。 这可以通过自动地使通信设备静音并且与诸如记录端点的另一端点建立通信信道来实现，以记录由通信设备发送的音频信号。

公开(公告)号：US20100326996A1

公开(公告)日：2010-12-30

申请号：US12493874

申请日：2009-06-29

Applicant: Paul McNamara

Inventor： Paul McNamara

IPC: B65D25/00

CPC classification number: B65D51/245 ,  B65D25/20 ,  B65D2203/00

Abstract: A decorative article support device which can be attached to a container or container lid. The device includes a chassis, a mount with a receptacle for displaying a decorative or other article and flexible legs attached to the chassis. The flexible legs enable the support device to be detachably attached to the container or container lid. In one embodiment, the flexible legs have an extensible part which enables the support device to be attached to containers of varying sizes. Decorative or other articles, such as small balloons, may be engaged with the receptacle on the chassis.

Abstract translation: 装饰物品支撑装置，其可以附接到容器或容器盖。 该装置包括底盘，具有用于显示装饰物或其它物品的插座的安装座以及附接到底盘的柔性支脚。 柔性腿使得支撑装置可拆卸地附接到容器或容器盖。 在一个实施例中，柔性腿具有可伸展部分，其使支撑装置能够附接到不同尺寸的容器。 诸如小气球的装饰物或其他物品可以与底盘上的容器接合。

公开(公告)号：US07617337B1

公开(公告)日：2009-11-10

申请号：US11671733

申请日：2007-02-06

Applicant: Alexander Beck ,  Colin Blair ,  Andrew W. Lang ,  Paul McNamara ,  David Thambiratnam

Inventor： Alexander Beck ,  Colin Blair ,  Andrew W. Lang ,  Paul McNamara ,  David Thambiratnam

IPC: G06F3/00

CPC classification number: H04L65/80

Abstract: The present invention provides methods and systems for improving VoIP quality in speech and similar communications. More specifically, various lower limits for network performance may be identified and in the event that the communication network begins performing below the lower limits a buffered conversation may be employed in an attempt to improve conversation quality.

Abstract translation: 本发明提供了用于改善语音和类似通信中的VoIP质量的方法和系统。 更具体地，可以识别网络性能的各种下限，并且在通信网络开始低于下限的情况下，可以采用缓冲的对话来尝试改善对话质量。

公开(公告)号：US20060219473A1

公开(公告)日：2006-10-05

申请号：US11096334

申请日：2005-03-31

Applicant: Simon Boland ,  Jonathan Choy ,  Paul McNamara

Inventor： Simon Boland ,  Jonathan Choy ,  Paul McNamara

IPC: G08B3/02

CPC classification number: H04L63/0861 ,  G08B13/1672 ,  G08B25/08 ,  H04L63/1408 ,  H04M11/04

Abstract: A voice communications terminal is provided that includes: a microphone 208 operable to receive an audio stream; and a voice activity detector 220 operable to (a) determine whether the audio stream comprises voice signals and (b) when the audio stream comprises voice signals, at least one of (i) notify a communications server 110 and (ii) provide at least a portion of the audio stream to the communications server 110.

Abstract translation: 提供一种语音通信终端，其包括：可操作以接收音频流的麦克风208; 和语音活动检测器220，其可操作以（a）确定音频流是否包括语音信号，以及（b）当音频流包括语音信号时，（i）通知通信服务器110和（ii）至少提供 到通信服务器110的音频流的一部分。

公开(公告)号：US20210320558A1

公开(公告)日：2021-10-14

申请号：US17264160

申请日：2019-08-14

Applicant: Paul MCNAMARA

Inventor： Paul MCNAMARA

IPC: H02K5/24 ,  A47J43/07 ,  G10K11/162

Abstract: A freestanding sound attenuating apparatus for a kitchen appliance has a rigid plastic dome defining an interior having an inner surface area and having a coplanar rim surrounding an inferior opening. The dome can therefore stand on a substantially planar surface with the kitchen appliance inserted via the inferior opening to be contained within the interior. The dome has a transparent window and sound absorbing material partially lining the inner surface area of the dome and which avoids the window. The sound absorbing material may line between 20-75% of the interior surface of the dome whilst conferring substantial sound attenuation properties evident from measurements contained herein.

公开(公告)号：US07930762B1

公开(公告)日：2011-04-19

申请号：US11530838

申请日：2006-09-11

Applicant: Colin Blair ,  Andrew W. Lang ,  David Thambiratnam ,  Alexander Beck ,  Paul McNamara ,  Karen L. Barrett ,  David Shaw ,  Verna L. Iles ,  Zao Te Mo

Inventor： Colin Blair ,  Andrew W. Lang ,  David Thambiratnam ,  Alexander Beck ,  Paul McNamara ,  Karen L. Barrett ,  David Shaw ,  Verna L. Iles ,  Zao Te Mo

IPC: G06F7/04 ,  H04N7/16

CPC classification number: H04N7/163 ,  H04N21/4143 ,  H04N21/42202 ,  H04N21/44218 ,  H04N21/4532

Abstract: Various systems and methods for automated media filtering are disclosed. For example, some methods include receiving an indication of a situational difference via an automatic sensor, and based at least in part on the situational difference, a program played on a media player is modified. In some cases, the methods further include accessing a filter that compares the change in situational difference with a predefined access control rule set. As just some of many examples, the situational difference may include a change in persons within proximity of the media player and/or a change in programming selection in relation to the media player.

Abstract translation: 公开了用于自动化介质过滤的各种系统和方法。 例如，一些方法包括通过自动传感器接收情景差异的指示，并且至少部分地基于情境差异，修改在媒体播放器上播放的节目。 在某些情况下，这些方法还包括访问将情境差异与预定义访问控制规则集进行比较的过滤器。 作为许多示例中的一些例子，情境差异可以包括媒体播放器附近的人的变化和/或与媒体播放器相关的节目选择的改变。

公开(公告)号：US20060281756A1

公开(公告)日：2006-12-14

申请号：US11448191

申请日：2006-06-07

Applicant: Jianshe Kong ,  Tao Meng ,  Paul McNamara ,  Xian Liang ,  Jesse Wong

Inventor： Jianshe Kong ,  Tao Meng ,  Paul McNamara ,  Xian Liang ,  Jesse Wong

IPC: A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/416 ,  C07D403/02 ,  C07D417/02

CPC classification number: C07D231/38

Abstract: This application discloses a novel process to synthesize 3-amino-4-substituted pyrazole derivatives, which may be used, for example, as intermediates to prepare compounds having, for example, pharmaceutical utility.

Abstract translation: 本申请公开了一种合成3-氨基-4-取代的吡唑衍生物的新方法，其可用于例如制备具有例如药物效用的化合物的中间体。

公开(公告)号：US20060028352A1

公开(公告)日：2006-02-09

申请号：US10911090

申请日：2004-08-03

Applicant: Paul McNamara ,  Muneyb Minhazuddin ,  Christopher Fegan ,  Rohan Lenard ,  Ralph Warta

Inventor： Paul McNamara ,  Muneyb Minhazuddin ,  Christopher Fegan ,  Rohan Lenard ,  Ralph Warta

IPC: G08B5/22 ,  G06Q30/00 ,  G08B1/08 ,  G08B13/14

CPC classification number: G06Q10/087 ,  G06Q10/00

Abstract: An enterprise network 100 for tracking objects is provided. The network 100 includes: (a) a plurality of subscriber communication devices 134 and 138; (b) a plurality of readers 160, each of the communication devices being in communication with a corresponding reader, wherein each reader is operable to read a set of object identifiers, each object identifier in the set corresponding to an Identification device 168 positioned on a respective object 164; and (c) a location agent 324 operable to determine, from at least one of the sets of object identifiers, a physical location of each object 164 having an object identifier in the at least one of the sets of object identifiers.

Abstract translation: 提供了用于跟踪对象的企业网络100。 网络100包括：（a）多个用户通信设备134和138; （b）多个读取器160，每个通信设备与对应的读取器通信，其中每个读取器可操作以读取一组对象标识符，集合中的每个对象标识符对应于位于 相应的对象164; 以及（c）位置代理324可操作以从所述对象标识符集合中的至少一个确定具有所述对象标识符集合中的所述至少一个对象标识符的每个对象164的物理位置。