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    Surveillance projectile
    3.
    发明申请
    Surveillance projectile 失效

    公开(公告)号：US20060283345A1

    公开(公告)日：2006-12-21

    申请号：US11154845

    申请日：2005-06-16

    申请人： Paul Feldman ,  Matthew Ray ,  James McNulty

    发明人： Paul Feldman ,  Matthew Ray ,  James McNulty

    IPC分类号： F42B5/02

    CPC分类号： F42B12/365

    摘要： A surveillance projectile consisting primarily of a very robust electronic device designed to be contained in a 40 mm cartridge that can be fired over distances through an open window or door and into a remote location, such as an enclosed site, where it is desirable to surreptitiously acquire intelligence by electronic means or by irradiating an interior with invisible infrared light to facilitate infrared sensing. The projectile may be configured to contain any of several types of surveillance devices. Such devices may be, but are not limited to, wirelessly operated cameras, audio transmitters, recorders and infrared illuminators. Audio transmission may be scrambled for decoding at a receiver.

    Short-acting benzodiazepines
    6.
    发明申请
    Short-acting benzodiazepines 有权
    短效苯二氮卓类

    公开(公告)号：US20070135420A1

    公开(公告)日：2007-06-14

    申请号：US11650636

    申请日：2007-01-05

    申请人： Paul Feldman ,  David Jung ,  Istvan Kaldor ,  Gregory Pacofsky ,  Jeffrey Stafford ,  Jeffrey Tidwell

    发明人： Paul Feldman ,  David Jung ,  Istvan Kaldor ,  Gregory Pacofsky ,  Jeffrey Stafford ,  Jeffrey Tidwell

    IPC分类号： A61K31/5513 ,  C07D403/02 ,  C07D243/14

    CPC分类号： C07D243/20 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D487/04

    摘要： It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The compounds of the present invention are suitable for therapeutic purposes, including sedative-hypnotic, anxiolytic, muscle relaxant and anticonvulsant purposes and are useful to be administered intravenously in the following clinical settings: preoperative sedation, anxiolysis, and amnestic use for perioperative events; conscious sedation during short diagnostic, operative or endoscopic procedures; as a component for the induction and maintenance of general anesthesia, prior and/or concomitant to the administration of other anesthetic agents; ICU sedation.

    摘要翻译： 现已发现如在含有羧酸酯部分的式（I）的苯并二氮杂衍生物中所描述的本发明化合物，由此能够在器官非依赖性消除机制中被非特异性组织酯酶灭活，从而提供更可预测和 可重现的药效学特征。 本发明的化合物适用于治疗目的，包括镇静催眠，抗焦虑药，肌肉松弛剂和抗惊厥药物，并可用于在以下临床环境中静脉内施用：术前镇静，抗焦虑和围手术期的遗忘用途; 短期诊断，手术或内窥镜手术中有意义的镇静; 作为全身麻醉的诱导和维持的组成部分，先前和/或伴随其他麻醉剂的施用; ICU镇静。